Int J Stem Cells.  2015 May;8(1):18-23. 10.15283/ijsc.2015.8.1.18.

Hormonal Regulation of Hematopoietic Stem Cells and Their Niche: A Focus on Estrogen

Affiliations
  • 1Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea. shhong@kangwon.ac.kr
  • 2Stem Cell Institute, Kangwon National University, Chuncheon, Korea.
  • 3Center of Stem Cell and Regenerative Medicine, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, China.
  • 4Graduate School of Biomedical Science and Engineering, Department of Biomedical Science, Hanyang University, Seoul, Korea.

Abstract

Self-renewal and differentiation are hallmarks of stem cells and controlled by various intrinsic and extrinsic factors. Increasing evidence indicates that estrogen (E2), the primary female sex hormone, is involved in regulating the proliferation and lineage commitment of adult and pluripotent stem cells as well as modulating the stem cell niche. Thus, a detailed understanding of the role of E2 in behavior of stem cells may help to improve their therapeutic potential. Recently, it has been reported that E2 promotes cell cycle activity of hematopoietic stem and progenitor cells and induces them to megakaryocyte-erythroid progenitors during pregnancy. This study paves the way towards a previously unexplored endocrine mechanism that controls stem cell behavior. In this review, we will focus on the scientific findings regarding the regulatory effects of E2 on the hematopoietic system including its microenvironment.

Keyword

Estrogen; Hematopoiesis; Niche; Stem cells

MeSH Terms

Adult
Cell Cycle
Estrogens*
Female
Hematopoiesis
Hematopoietic Stem Cells*
Hematopoietic System
Humans
Megakaryocyte-Erythroid Progenitor Cells
Pluripotent Stem Cells
Pregnancy
Stem Cell Niche
Stem Cells
Estrogens

Reference

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