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Relationship between meiotic spindles visualization and intracytoplasmic sperm injection outcomes in human oocytes

Asa E, Tabatabaee R, Farrokhi A, Nejatbakhsh R

In assisted reproductive techniques, the operator attempts to select morphologically best embryos to predict embryo viability. Development of polarized light microscope, which evaluates the oocytes' spindles according to birefringence of...
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Effects of chlorinated aliphatic hydrocarbons on the fidelity of cell division in human CYP2E1 expressing cells

Kim A, Parry EM, Parry JM

  • KMID: 1093602
  • Exp Mol Med.
  • 2002 Mar;34(1):83-89.
Chlorinated organic chemicals are widely used in industry and are present in the environment. Five chlorinated aliphatic hydrocarbons, namely 1-2-dichloroethane, 1,1,2-trichloroethane, trichloroethylene, 2,3-dichlorobutane and 1-chlorohexane were investigated to determine their...
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Damage of Intracytoplasmic Meiotic Spindles in Cryopreserved-Thawed Mouse Oocytes

Kim SH, Choi SM, Jee BC, Kim HS, Oh SK, Suh CS, Choi YM, Kim JG, Lee JY, Moon SY

  • KMID: 2076337
  • Korean J Obstet Gynecol.
  • 2001 Sep;44(9):1602-1608.
OBJECTIVE: To investigate the extent of meiotic spindle damages in cryopreserved-thawed mouse mature oocytes. METHODS: After slow freezing and ultra-rapid thawing using 1.5M dimethylsulfoxide(DMSO), mouse mature oocytes were stained by...
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Kinesin superfamily protein member 4 (KIF4) is localized to midzone and midbody in dividing cells

Lee YM, Kim W

  • KMID: 755671
  • Exp Mol Med.
  • 2004 Feb;36(1):93-97.
In association with microtubules, a variety of kinesins play important roles in cellular functions such as intracellular transport of organelles or vesicles, signal transduction, and cell division. In a previous...
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Sec13 induces genomic instability in U2OS cells

Sihn CR, Suh EJ, Lee KH, Kim SH

  • KMID: 1056239
  • Exp Mol Med.
  • 2005 Jun;37(3):255-260.
Sec13p has been known as an endoplasmic reticulum-Golgi transport protein. Recently, it has also been shown to be required for the formation of septation in the fission yeast Schizosaccharomyces pombe....
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Changes of Cytoskeletal System in Neurodegenerative Disease: Immunohistochemical Characterization of Neurofibrillary Changes Induced by Mitotic Spindle Inhibitors

Koo H

In experimental neurogenerative diseases, aluminum(Al) intoxication and axotomized sensory neurons showed an abnormal accumulation of neurofilaments(NF) in the neuronal perikarya. These NF contain phosphorylated(ph) epitopes that are not detectable in...
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Centrosome amplification and multinuclear phenotypes are Induced by hydrogen peroxide

Chae S, Yun C, Um H, Lee JH, Cho H

  • KMID: 1089458
  • Exp Mol Med.
  • 2005 Oct;37(5):482-487.
Multinucleated cells resulted from mitosis defect have been noted in pathophysiological states of the cells such as inflammation, senescence and cancer. Since oxidative stress has been known to correlate with...
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The p90 ribosomal S6 kinase 2 specifically affects mitotic progression by regulating the basal level, distribution and stability of mitotic spindles

Park YY, Nam HJ, Do M, Lee JH

RSK2, also known as RPS6KA3 (ribosomal protein S6 kinase, 90 kDa, polypeptide 3), is a downstream kinase of the mitogen-activated protein kinase (MAPK) pathway, which is important in regulating survival, transcription,...
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Electrophysiologic and morphologic changes of rat peripheral nerves induced by vincristine sulfate

Park KD, Sunwoo IN, Koo H

  • KMID: 2066089
  • J Korean Neurol Assoc.
  • 1997 Jun;15(3):586-605.
Vincristine has been extensively need in chemotherapy to treat leukemia, lymphoma, and a variety of solid tumor. The major antitumor effect has been known to be associated with its high...
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The Differential Gene Expression Profiles between Sensitive and Resistant Breast Cancer Cells to Adriamycin by cDNA Microarray

Ahn MJ, Lee KH, Ahn JI, Yu DH, Lee HS, Choi JH, Jang JS, Bae JM, Lee YS

  • KMID: 1807305
  • Cancer Res Treat.
  • 2004 Feb;36(1):43-49.
PURPOSE: Adriamycin(R) is one of the most commonly used drugs in the treatment of breast cancer. This study was performed to understand the molecular mechanisms of drug resistance in breast...
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