- Aging-Related Correlation between Serum Sirtuin 1 Activities and Basal Metabolic Rate in Women, but not in Men
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Lee HJ, Yang SJ
- KMID: 2377798
- Clin Nutr Res.
- 2017 Jan;6(1):18-26.
- doi: 10.7762/cnr.2017.6.1.18
Sirtuin (SIRT) is a main regulator of metabolism and lifespan, and its importance has been implicated in the prevention against aging-related diseases. The purpose of this study was to identify... -
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- Enhanced Viral Replication by Cellular Replicative Senescence
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Kim JA, Seong RK, Shin OS
- KMID: 2355022
- Immune Netw.
- 2016 Oct;16(5):286-295.
- doi: 10.4110/in.2016.16.5.286
Cellular replicative senescence is a major contributing factor to aging and to the development and progression of aging-associated diseases. In this study, we sought to determine viral replication efficiency of... -
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- SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential
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Kitada M, Koya D
- KMID: 1965977
- Diabetes Metab J.
- 2013 Oct;37(5):315-325.
- doi: 10.4093/dmj.2013.37.5.315
The prevalence of type 2 diabetes mellitus (T2DM) has been increasing worldwide. Therefore, a novel therapeutic strategy by which to prevent T2DM is urgently required. Calorie restriction (CR) can retard... -
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- Roles of Reactive Oxygen Species in Rheumatoid Arthritis Pathogenesis
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Yoo SJ, Go E, Kim YE, Lee S, Kwon J
- KMID: 2364687
- J Rheum Dis.
- 2016 Dec;23(6):340-347.
- doi: 10.4078/jrd.2016.23.6.340
Rheumatoid arthritis (RA) is an autoimmune disease that starts with decreased tolerance to modified self-antigens and eventually leads to synovitis and destruction of bone and cartilage. Age is a risk... -
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- The Protective Effect of Egb 761 Against 3-Nitropropionic Acid-Induced Hearing Loss: The Role of Sirtuin 1
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Chang MY, Rhee J, Kim SH, Kim YH
- KMID: 2407786
- Clin Exp Otorhinolaryngol.
- 2018 Mar;11(1):9-16.
- doi: 10.21053/ceo.2017.00626
OBJECTIVES: Local administration of 3-nitropropionic acid (3-NP) to the inner ear induces sensorineural hearing loss. Several studies have shown the otoprotective effects of ginkgo biloba extract EGb 761. Moreover, EGb... -
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- Expression of SIRT1 and DBC1 in Gastric Adenocarcinoma
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Kang Y, Jung WY, Lee H, Lee E, Kim A, Kim BH
- KMID: 2012052
- Korean J Pathol.
- 2012 Dec;46(6):523-531.
BACKGROUND: Sirtuin 1 (SIRT1) and deleted in breast cancer 1 (DBC1) are known as tumor suppressor or promoter genes. This may be due to their diverse functions and interaction with... -
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- BRCA1 and Breast Cancer: a Review of the Underlying Mechanisms Resulting in the Tissue-Specific Tumorigenesis in Mutation Carriers
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Semmler L, Reiter-Brennan C, Klein A
- KMID: 2441847
- J Breast Cancer.
- 2019 Mar;22(1):1-14.
- doi: 10.4048/jbc.2019.22.e6
Since the first cloning of BRCA1 in 1994, many of its cellular interactions have been elucidated. However, its highly specific role in tumorigenesis in the breast tissue—carriers of BRCA1 mutations... -
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- Nerve growth factor upregulates sirtuin 1 expression in cholestasis: a potential therapeutic target
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Tsai MS, Lee PH, Sun CK, Chiu TC, Lin YC, Chang IW, Chen PH, Kao YH
- KMID: 2438356
- Exp Mol Med.
- 2018 Jan;50(1):e426.
- doi: 10.1038/emm.2017.235
This study investigated the regulatory role of nerve growth factor (NGF) in sirtuin 1 (SIRT1) expression in cholestatic livers. We evaluated the expression of NGF and its cognate receptors in... -
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- Nicotinamide Reduces Amyloid Precursor Protein and Presenilin 1 in Brain Tissues of Amyloid Beta-Tail Vein Injected Mice
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Kim EJ, Yang SJ
- KMID: 2383701
- Clin Nutr Res.
- 2017 Apr;6(2):130-135.
- doi: 10.7762/cnr.2017.6.2.130
The purpose of this study is to investigate whether nicotinic acid (NA) and nicotinamide (NAM) reduce the Alzheimer disease (AD)-related gene expression in brain tissues of amyloid beta (Aβ)-injected mice.... -
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- Involvement of miR-Let7A in inflammatory response and cell survival/apoptosis regulated by resveratrol in THP-1 macrophage
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Song J, Jun M, Ahn MR, Kim OY
- KMID: 2390139
- Nutr Res Pract.
- 2016 Aug;10(4):377-384.
- doi: 10.4162/nrp.2016.10.4.377
BACKGROUND/OBJECTIVES: Resveratrol, a natural polyphenol, has multiple functions in cellular responses including apoptosis, survival, and differentiation. It also participates in the regulation of inflammatory response and oxidative stress. MicroRNA-Let-7A (miR-Let7A),... -
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- Everolimus Plus Ku0063794 Regimen Promotes Anticancer Effects against Hepatocellular Carcinoma Cells through the Paradoxical Inhibition of Autophagy
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Lee SC, Kim KH, Kim OH, Lee SK, Hong HE, Choi BJ, Jeong W, Kim SJ
- KMID: 2417890
- Cancer Res Treat.
- 2018 Jul;50(3):1023-1038.
- doi: 10.4143/crt.2017.085
PURPOSE: Everolimus only inhibits mammalian target of rapamycin complex 1 (mTORC1), whereas Ku0063794 inhibits both mTORC1 and mTORC2. Although they have similar anticancer effects, their combination has a synergistic effect... -
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- Myeloid-specific SIRT1 Deletion Aggravates Hepatic Inflammation and Steatosis in High-fat Diet-fed Mice
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Kim KE, Kim H, Heo RW, Shin HJ, Yi CO, Lee DH, Kim HJ, Kang SS, Cho GJ, Choi WS, Roh GS
- KMID: 2285590
- Korean J Physiol Pharmacol.
- 2015 Sep;19(5):451-460.
- doi: 10.4196/kjpp.2015.19.5.451
Sirtuin 1 (SIRT1) is a mammalian NAD+-dependent protein deacetylase that regulates cellular metabolism and inflammatory response. The organ-specific deletion of SIRT1 induces local inflammation and insulin resistance in dietary and... -
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- Resveratrol attenuates 4-hydroxy-2-hexenal-induced oxidative stress in mouse cortical collecting duct cells
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Bae EH, Joo SY, Ma SK, Lee J, Kim SW
- KMID: 2285594
- Korean J Physiol Pharmacol.
- 2016 May;20(3):229-236.
- doi: 10.4196/kjpp.2016.20.3.229
Resveratrol (RSV) may provide numerous protective eff ects against chronic inflammatory diseases. Due to local hypoxia and hypertonicity, the renal medulla is subject to extreme oxidative stress, and aldehyde products... -
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- Age-related Changes in the Sirtuin1-NFE2-related Factor 2 Signaling System in the Kidney
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Bae MN, Choi MS, Eum SH, Kim EN, Lim JH, Kim MY, Ban TH, Jang IA, Yoon HE, Park CW, Chang YS, Choi BS
- KMID: 2376944
- Korean J Med.
- 2017 Feb;92(1):53-61.
- doi: 10.3904/kjm.2017.92.1.53
BACKGROUND/AIMS: Renal aging-related changes are characterized by oxidative stress. SIRT1 regulates cellular conditions by activating Nrf2. The present study investigated the processes of renal changes by antioxidant enzymes and the... -
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- The Role of SIRT1 in Central Nervous System
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Chung S, Choi SH, Shin KH
- KMID: 2287453
- Korean J Psychopharmacol.
- 2013 Apr;24(2):43-58.
Silent mating type information regulation 2 homolog 1 (SIRT1) is a nicotinamide adenosine dinucleotide (NAD+)-dependent class III histone deacetylase and is distributed in central nervous system and peripheral tissue. SIRT1... -
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- Nicotinamide riboside regulates inflammation and mitochondrial markers in AML12 hepatocytes
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Lee HJ, Yang SJ
- KMID: 2434070
- Nutr Res Pract.
- 2019 Feb;13(1):3-10.
- doi: 10.4162/nrp.2019.13.1.3
BACKGROUND/OBJECTIVES: The NAD+ precursor nicotinamide riboside (NR) is a type of vitamin B3 found in cow's milk and yeast-containing food products such as beer. Recent studies suggested that NR prevents... -
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- Effects of dietary leucine supplementation on the hepatic mitochondrial biogenesis and energy metabolism in normal birth weight and intrauterine growth-retarded weanling piglets
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Su W, Xu W, Zhang H, Ying Z, Zhou L, Zhang L, Wang T
- KMID: 2412024
- Nutr Res Pract.
- 2017 Apr;11(2):121-129.
- doi: 10.4162/nrp.2017.11.2.121
BACKGROUND/OBJECTIVES: The study was conducted to evaluate the effects of dietary leucine supplementation on mitochondrial biogenesis and energy metabolism in the liver of normal birth weight (NBW) and intrauterine growth-retarded... -
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- SIRT1 Expression Is Associated with Good Prognosis in Colorectal Cancer
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Jung W, Hong KD, Jung WY, Lee E, Shin BK, Kim HK, Kim A, Kim BH
- KMID: 2277409
- Korean J Pathol.
- 2013 Aug;47(4):332-339.
BACKGROUND: Silent mating type information regulation 2 homolog 1 (SIRT1), an NAD+-dependent deacetylase, might act as a tumor promoter by inhibiting p53, but may also as a tumor suppressor by... -
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