- Natural Compound Shikonin Induces Apoptosis and Attenuates Epithelial to Mesenchymal Transition in Radiation-Resistant Human Colon Cancer Cells
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Shilnikova K, Piao MJ, Kang KA, Madushan Fernando PDS, Lakmini Herath HMU, Cho SJ, Hyun JW
- KMID: 2526815
- Biomol Ther.
- 2022 Mar;30(2):137-144.
- doi: 10.4062/biomolther.2021.088
Radiation resistance represents an imperative obstacle in the treatment of patients with colorectal cancer, which remains difficult to overcome. Here, we explored the anti-proliferative and migration-inhibiting properties of the natural... -
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- Reduced Autophagy in 5-Fluorouracil Resistant Colon Cancer Cells
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Yao CW, Kang KA, Piao MJ, Ryu YS, Fernando P, Oh MC, Park JE, Shilnikova K, Na SY, Jeong SU, Boo SJ, Hyun JW
- KMID: 2378810
- Biomol Ther.
- 2017 May;25(3):315-320.
- doi: 10.4062/biomolther.2016.069
We investigated the role of autophagy in SNUC5/5-FUR, 5-fluorouracil (5-FU) resistant SNUC5 colon cancer cells. SNUC5/5-FUR cells exhibited low level of autophagy, as determined by light microscopy, confocal microscopy, and... -
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- Galangin Activates the ERK/AKT-Driven Nrf2 Signaling Pathway to Increase the Level of Reduced Glutathione in Human Keratinocytes
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Hewage SR, Piao MJ, Kang KA, Ryu YS, Fernando P, Oh MC, Park JE, Shilnikova K, Moon YJ, Shin DO, Hyun JW
- KMID: 2386910
- Biomol Ther.
- 2017 Jul;25(4):427-433.
- doi: 10.4062/biomolther.2016.112
Previously, we demonstrated that galangin (3,5,7-trihydroxyflavone) protects human keratinocytes against ultraviolet B (UVB)-induced oxidative damage. In this study, we investigated the effect of galangin on induction of antioxidant enzymes involved... -
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- A Benzylideneacetophenone Derivative Induces Apoptosis of Radiation-Resistant Human Breast Cancer Cells via Oxidative Stress
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Park JE, Piao MJ, Kang KA, Shilnikova K, Hyun YJ, Oh SK, Jeong YJ, Chae S, Hyun JW
- KMID: 2386907
- Biomol Ther.
- 2017 Jul;25(4):404-410.
- doi: 10.4062/biomolther.2017.010
Benzylideneacetophenone derivative (1E)-1-(4-hydroxy-3-methoxyphenyl) hept-1-en-3-one (JC3) elicited cytotoxic effects on MDA-MB 231 human breast cancer cells-radiation resistant cells (MDA-MB 231-RR), in a dose-dependent manner, with an IC₅₀ value of 6 μM... -
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- Protective Effect of an Isoflavone, Tectorigenin, Against Oxidative Stress-induced Cell Death via Catalase Activation
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Zhang R, Piao MJ, Oh MC, Park JE, Shilnikova K, Moon YJ, Kim DH, Jung U, Kim IG, Hyun JW
- KMID: 2367563
- J Cancer Prev.
- 2016 Dec;21(4):257-263.
- doi: 10.15430/JCP.2016.21.4.257
BACKGROUND: Isoflavones are biologically active compounds that occur naturally in a variety of plants, with relatively high levels in soybean. Tectorigenin, an isoflavone, protects against hydrogen peroxide (H2O2)-induced cell damage.... -
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