- G1/S Cell Cycle Checkpoint Defect in Lymphocytes from Patients with Alzheimer's Disease
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Song M, Kwon YA, Lee Y, Kim H, Yun JH, Kim S, Kim DK
- KMID: 2316235
- Psychiatry Investig.
- 2012 Dec;9(4):413-417.
OBJECTIVE: We compared the cell responsiveness of activated lymphocytes to rapamycin, which blocks the G1/S transition, between patients with Alzheimer's disease (AD) and normal controls to assess the early phase... -
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- B-1 Cells Differ from Conventional B (B-2) Cells: Difference in Proliferation
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Yeo SG, Cho JS, Park DC, Rothstein
- KMID: 2167976
- Immune Netw.
- 2004 Sep;4(3):155-160.
- doi: 10.4110/in.2004.4.3.155
BACKGROUND: B-1 cells differ from conventional B-2 cells both phenotypically and functionally. The aim of this study was to investigate the difference between peritoneal B-1 cells and splenic B-2 cells... -
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- Expression of brdU in BBN induced rat bladder tumor
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Kim WJ, Song HG, Kim YK
- KMID: 2036792
- Korean J Urol.
- 1993 Feb;34(1):1-6.
We labeled-S-phase cell in BBN induced rat bladder tumors using anti-bromodeoxyuridine anti- body. The thymidine analogue, bromodeoyuridine (BrdU), was incorporated into DNA during the S -phase or the cell cycle.... -
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- S Phase Kinase Associated Protein 2 Expression in Breast Cancer and Its Prognostic Implications
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Chang ED, Lee EJ, Oh SJ, Kang CS
- KMID: 2275422
- Korean J Pathol.
- 2005 Apr;39(2):69-73.
BACKGROUND: S Phase Kinase Associated Protein 2 (Skp2), an F-box protein necessary for DNA replication, has recently been demonstrated to be an oncogene. The purpose of this study was to... -
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- Correlation between DNA ploidy, pathological stage and prognosis in renal cell carcinoma
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Suh JK, Park YI
- KMID: 2139553
- Korean J Urol.
- 1991 Dec;32(6):867-872.
The correlation between deoxyribonucleic acid (DNA) ploidy, pathological stage and prognosis was evaluated in 18 patients, who underwent nephrectomy and proved to be renal cell carcinoma. Of them, 10 (56%)... -
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- Changes in the Rate of Renin Secretion During Cell Cycle of As 4.1 Cells
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Kim MK, Kim MH, Chang JW, Leem CH, Jang YJ, Park CS
- KMID: 2079304
- Korean J Nephrol.
- 2003 Sep;22(5):512-521.
BACKGROUND: Renin is secreted from the juxtaglomerular (JG) cells in response to a wide variety of extracellular stimuli. To study the underlying mechanism of regulation of renin secretion at molecular... -
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- Cell Death Induction Mechanism of Non-small Cell Lung Cancer Cell Line, NCI-H1703 by Docetaxel
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Ha HC, Kim YD, Song SH, Park CS, Kim JW
- KMID: 1878599
- Korean J Thorac Cardiovasc Surg.
- 2006 Sep;39(9):668-673.
BACKGROUND: Docetaxel has been effectively used as an anti-cancer chemotherapuetic agent for various tumor treatments including lung cancer. However, the cell death induction mechanism(s) involved with docetaxel treatment in lung... -
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- Correlation of Proliferating Cell Nuclear Antigen (PCNA) Expression and S-phase Fraction, Survival Rate in Primary Non-Small Cell Lung Cancer
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Yang SH, Kim HR, Gu KS, Jung BH, Jeong ET
- KMID: 2318055
- Tuberc Respir Dis.
- 1997 Aug;44(4):756-765.
BACKGROUND: To study the prognosis of patients with lung cancer, many investigators have reported the methods to detect cell proliferation in tissues including PCNA, thymidine autoradiography, flow cytometry and Ki-67.... -
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- Expression of Cyclin A and Ki-67 in the Uterine Cervical Carcinoma
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Kim MK, Bae DH, Kim CJ
- KMID: 2244993
- Korean J Gynecol Oncol Colposc.
- 1998 Dec;9(4):464-470.
The cell cycle is the set of events that is responsible for the duplication of the cells. Recent studies indicate that cell cycle regulatory proteins, mainly the cyclins and cyclin-related... -
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- The Effects of Immunosuppressants Rapamycin and Cyclosporin A on the Proliferation, Cell Cycle, and Cyclin Expression of Cultured Human Keratinocyte Cell Line HaCaT Cells
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Choi JH, Suh HS, Chung ST, Suh CW, Park EM, Sung KJ
- KMID: 2303303
- Korean J Dermatol.
- 1998 Aug;36(4):561-570.
BACKGROUND: Rapamycin and cyclosporin A display an immunosuppressive effect by inhibiting the proliferation of T lymphocytes. Both immunosuppressants are effective in the treatment of psoriasis which is considered to be... -
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- The Expression of p53 and p21 in Intradermal Nevus, Junctional Nevus and Malignant Melanoma
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Song MH, Kim YT, Jang WS, Lee SY, Yang SH, Lee JS, Whang KU, Kim EH
- KMID: 2303110
- Korean J Dermatol.
- 2002 Aug;40(8):869-873.
BACKGROUND: The function of the p53 protein is known to regulate cell proliferation by inhibiting cells entering S phase, so DNA damaged cell proliferation is inhibited by apoptosis. p21 is... -
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- Etoposide-induced Smad6 expression is required for the G1 to S phase transition of the cell cycle in CMT-93 mouse intestinal epithelial cells
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Lee YS, Lee EK, Han IO, Park SH
- KMID: 1103587
- Exp Mol Med.
- 2008 Feb;40(1):43-51.
- doi: 10.3858/emm.2008.40.1.43
The inhibitory Smad6 and Smad7 are responsible for cross-talk between TGF-beta/bone morphogenic protein (BMP) signaling and other cellular signaling pathways, as well as negative feedback on their own signaling functions.... -
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- Cell kinetics of human transitional cell carcinoma of the bladder by in vitro bromodeoxyuridine labeling
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Lee SW, Kim WJ, Lee SE, Kim YK
- KMID: 1913455
- Korean J Urol.
- 1992 Feb;33(1):1-6.
We labeled S-phase cell in human bladder tumors using anti-bromodeoxyuridine (BrdU) antibody. The thymidine analogue, BrdU, was incorporated into DNA synthesis phase by in vitro labeling technique. Separate samples of... -
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- Cell cycling status of human cord blood CD34+ cells during ex vivo expansion is related to the level of very late antigen expression
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Seoh JY, Park HY, Chung WS, Kim SC, Hahn MJ, Kim KH, Shin HY, Ahn HS, Park KW, Ryu KH
- KMID: 1066489
- J Korean Med Sci.
- 2001 Feb;16(1):20-24.
- doi: 10.3346/jkms.2001.16.1.20
Very late antigen-4 (VLA-4), which binds to the extracellular matrix protein fibronectin, is an integrin molecule known to be modulated during mobilization of CD34+ cells, and to be involved in... -
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- Effects of HMGB-1 Overexpression on Cell-Cycle Progression in MCF-7 Cells
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Yoon S, Lee JY, Yoon BK, Bae DS, Choi DS
- KMID: 1786806
- J Korean Med Sci.
- 2004 Jun;19(3):321-326.
- doi: 10.3346/jkms.2004.19.3.321
High mobility group-1 (HMGB-1) enhances the DNA interactions and possesses a transcriptional activation potential for several families of sequence-specific transcriptional activators. In order to examine the effect of HMGB-1 on... -
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- Effects of treatment sequence of cisplatin and paclitaxel (taxol) on cell cycle and cell death in NIHOVCAR-3 cell line
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Jo HH, Kim YO, Yoo YO, Park GY, Park CH, Ryu GS, Na JG, Kim SP, Han GT
- KMID: 2262182
- Korean J Obstet Gynecol.
- 2001 Jan;44(1):128-133.
The overt effects of the anticancer drugs such as cisplatin and taxol appear to be DNA modification and microtubule stabilization respectively. But the mechanism by which these drugs affect tumor... -
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- Effect of Nitric Oxide on the Viability of Bone Marrow - Derived Cultured Mast Cells
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Chung HT, Park RK, Jun CD, Choi BM, Lee SJ
- KMID: 1548384
- Korean J Immunol.
- 1997 Dec;19(4):595-600.
It is well established that mast cell proliferation and maturation are regulated by two principle cytokines, IL-3 and the c-kit ligand stem cell factor (SCF). Previous reports have demonstrated that... -
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- Cell Cycle Analysis by Ki-67 Monoclonal Antibody in Acute Myelogenous Leukemia
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Ahn JS, Kim ES, Kim HT, Park SY, Kim BK
- KMID: 1641956
- Korean J Hematol.
- 2002 Aug;37(3):191-199.
BACKGROUND: Flow cytometric measurement of DNA can reveal G0/G1, S, G2/M phases of cell cycle, and BrdU labeling can determine the percentage of cells in active DNA synthesis. A monoclonal... -
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- Study of the Relationships between Cyclin D1 and Known Prognostic Factors in Breast Cancer
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Kim JY, Choi YM, Kim SJ, Shin SH, Ahn SI, Woo ZH
- KMID: 2209263
- J Korean Surg Soc.
- 2000 Mar;58(3):337-344.
PURPOSE: Cyclin D1, which is known as a cell regulatory protein in G1-S phase, is overexpressed in 30-90% of breast cancers. Published data on the relationships between cyclin D1 and... -
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- Indole-3-carbinol and genistein inhibit growth of human uterine leiomyoma cells
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Jeong HW, Kim YO, Shin SJ, Kwon SH, Cha SD, Cho CH
- KMID: 2077761
- Korean J Obstet Gynecol.
- 2007 Jun;50(6):880-886.
OBJECTIVE: To determine whether Indole-3-carbinol (I3C) can enhance the inhibitory effect of genistein on a human uterine leiomyoma cells. METHODS: Five uterine leiomyoma tissues were obtained from hysterectomies conducted on... -
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