- Inhibitory effect of Mg2+ on the release of Ca2+ from Ryanodine receptor of the sarcoplasmic reticulum in the skeletal muscle
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Lee CJ
- KMID: 1686430
- Korean J Thorac Cardiovasc Surg.
- 1992 Apr;25(4):347-355.
No abstract available. -
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- Thyroid hormone-induced alterations of ryanodine and dihydropyridine receptor protein expression in rat hear
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Kim HW, Park M, Lee EH, Cho HJ, Lee HR
- KMID: 2285227
- Korean J Physiol Pharmacol.
- 1999 Jun;3(3):329-337.
Thyroid hormone-induced cellular dysfunctions may be associated with changes in the intracellular Ca2+ concentration. The ryanodine receptor, a Ca2+ release channel of the SR, is responsible for the rapid release of Ca2+ that... -
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- Ryanodine Receptor-mediated Calcium Release Regulates Neuronal Excitability in Rat Spinal Substantia Gelatinosa Neurons
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Park A, Chun SW
- KMID: 2133226
- Int J Oral Biol.
- 2015 Dec;40(4):211-216.
- doi: 10.11620/IJOB.2015.40.4.211
Nitric Oxide (NO) is an important signaling molecule in the nociceptive process. Our previous study suggested that high concentrations of sodium nitroprusside (SNP), a NO donor, induce a membrane hyperpolarization... -
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- Unchanged protein level of ryanodine receptor but reduced (3H) ryanodine binding of cardiac sarcoplasmic reticulum from diabetic cardiomyopathy rats
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Lee EH, Seo YJ, Kim YH, Kim HW
- KMID: 1607079
- Korean J Physiol Pharmacol.
- 2001 Oct;5(5):397-405.
The ryanodine receptor, a Ca2+ release channel of the sarcoplasmic reticulum (SR), is responsible for the rapid release of Ca2+ that activates cardiac muscle contraction. In the excitation-contraction coupling cascade, activation of SR... -
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- (3H)Ryanodine binding sites of SR vesicles of the chicken pectoral muscle
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Yun HY, Jeon JR, Hong JH, Hur GM, Lee JH, Seok JH
- KMID: 2071509
- Korean J Physiol Pharmacol.
- 1997 Aug;1(4):377-384.
To investigate the properties of ryanodine binding sites of the bird skeletal SR vesicles, SDS PAGE, purification of RyR, and (3H)ryanodine binding study were carried out in the SR vesicles prepared from... -
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- Na+-Ca2+ Exchange Curtails Ca2+ before Its Diffusion to Global Ca2+i in the Rat Ventricular Myocyte
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Ahn SW, Ko CM
- KMID: 2285315
- Korean J Physiol Pharmacol.
- 2005 Apr;9(2):95-101.
In the heart, Na+-Ca2+ exchange (NCX) is the major Ca2+ extrusion mechanism. NCX has been considered as a relaxation mechanism, as it reduces global [Ca2+]i raised during activation. However, if... -
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- Modulation of Dopaminergic Neuronal Excitability by Zinc through the Regulation of Calcium-related Channels
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Noh J, Chung JM
- KMID: 2463713
- Exp Neurobiol.
- 2019 Oct;28(5):578-592.
- doi: 10.5607/en.2019.28.5.578
Depending on the intracellular buffering of calcium by chelation, zinc has the following two apparent effects on neuronal excitability: enhancement or reduction. Zinc increased tonic activity in the depolarized state... -
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- Delayed Onset of Malignant Hyperthermia: A Case Report
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Lim JW, Yeo SK, Yang SH, Hwang IS, Lee JS
- KMID: 2228326
- Korean J Crit Care Med.
- 2009 Dec;24(3):168-171.
- doi: 10.4266/kjccm.2009.24.3.168
Malignant hyperthermia is a potentially fatal genetic and metabolic myopathy that presents with high fever, and muscle rigidity, and it often occurs after administering anesthetic medication. Most cases of malignant... -
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- Alteration of Ryanodine-receptors in Cultured Rat Aortic Smooth Muscle Cells
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Kim EJ, Kim DK, Kim SH, Lee KM, Park HS, Kim SH
- KMID: 2285431
- Korean J Physiol Pharmacol.
- 2011 Dec;15(6):431-436.
- doi: 10.4196/kjpp.2011.15.6.431
Vascular smooth muscle cells can obtain a proliferative function in environments such as atherosclerosis in vivo or primary culture in vitro. Proliferation of vascular smooth muscle cells is accompanied by... -
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- Ca(2+)-induced Ca2+ Release from Internal Stores in INS-1 Rat Insulinoma Cells
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Choi KJ, Cho DS, Kim JY, Kim BJ, Lee KM, Kim SH, Kim DK, Kim SH, Park HS
- KMID: 2389109
- Korean J Physiol Pharmacol.
- 2011 Feb;15(1):53-59.
The secretion of insulin from pancreatic beta-cells is triggered by the influx of Ca2+ through voltage-dependent Ca2+ channels. The resulting elevation of intracellular calcium ([Ca2+]i) triggers additional Ca2+ release from... -
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- Heterogeneity of the SR-dependent Inward Na+-Ca2+ Exchange Current in the Heavily Ca2+-buffered Rat Ventricular Myocytes
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Yoon KB, Ahn SW, Ko CM
- KMID: 1611236
- Korean J Physiol Pharmacol.
- 2004 Apr;8(2):101-110.
Voltage-sensitive release mechanism was pharmacologically dissected from the Ca2+-induced Ca2+ release in the SR Ca2+ release in the rat ventricular myocytes patch-clamped in a whole-cell mode. SR Ca2+ release process... -
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- Characteristics of Ca2+ stores in rabbit cerebral artery myocytes
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Kim SJ, Kim JK, So I, Suh SH, Lee SJ, Kim KW
- KMID: 1849839
- Korean J Physiol Pharmacol.
- 1998 Jun;2(3):313-322.
In a myocyte freshly isolated from rabbit cerebral artery, the characteristics of Ca2+ release by histamine or caffeine were studied by microspectrofluorimetry using a Ca2+-binding fluorescent dye, fura-2. Histamine (5 micrometer) or caffeine... -
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- TRPC3 cation channel plays an important role in proliferation and differentiation of skeletal muscle myoblasts
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Woo JS, Cho CH, Kim DH, Lee EH
- KMID: 983954
- Exp Mol Med.
- 2010 Sep;42(9):614-627.
- doi: 10.3858/emm.2010.42.9.061
During membrane depolarization associated with skeletal excitation-contraction (EC) coupling, dihydropyridine receptor [DHPR, a L-type Ca2+ channel in the transverse (t)-tubule membrane] undergoes conformational changes that are transmitted to ryanodine receptor... -
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- Fast and slow gating types of SR ryanodine receptor/channel purified from canine latissimus dorsi muscle
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Shin JH, Yoo GH, Lee CJ, Suh CK
- KMID: 699876
- Yonsei Med J.
- 1996 Feb;37(1):72-80.
- doi: 10.3349/ymj.1996.37.1.72
The ryanodine receptor/channel (RyR) mediates the release of calcium from the sarcoplasmic reticulum (SR) in both skeletal and cardiac muscle cells. There are three isoforms of the RyR: RyR1, RyR2,... -
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- A Family of Congenital Fiber Type Disproportion with Mutation in Tropomyosin 3 (TPM3) Gene Presenting as Altered Mentality with Respiratory Distress
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Namgung DW, Hong JM, Lee JH, Park HJ, Choi YC
- KMID: 2454845
- J Korean Neurol Assoc.
- 2019 May;37(2):174-177.
- doi: 10.17340/jkna.2019.2.10
Congenital fiber type disproportion (CFTD) has been related with mutations in ACTA1, SEPN1, RYR1 and tropomyosin 3 (TPM3) genes. Particularly, TPM3 mutation was identified as one of the most frequent... -
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- Malignant hyperthermia
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Kim DC
- KMID: 1767205
- Korean J Anesthesiol.
- 2012 Nov;63(5):391-401.
- doi: 10.4097/kjae.2012.63.5.391
Malignant hyperthermia (MH) is an uncommon, life-threatening pharmacogenetic disorder of the skeletal muscle. It presents as a hypermetabolic response in susceptible individuals to potent volatile anesthetics with/without depolarizing muscle relaxants;... -
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- Homo-dimerization of RyR1 C-terminus via charged residues in random coils or in an alpha-helix
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Lee EH, Allen PD
- KMID: 1090962
- Exp Mol Med.
- 2007 Oct;39(5):594-602.
To investigate the mechanism by which the C-terminus (4,938-5,037) of the ryanodine receptor 1 (RyR1) homo-tetramerizes, forming a functional Ca2+ -release channel, the structural requirements for the tetramerization were studied... -
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- Anesthetic experience for patients with malignant hyperthermia susceptibility determined by molecular genetic test: A report of 2 cases
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Lee JW, Yi JS, Lee JR, Kim DC
- KMID: 2236514
- Korean J Anesthesiol.
- 2009 Sep;57(3):387-391.
- doi: 10.4097/kjae.2009.57.3.387
Malignant hyperthermia (MH) is a potentially fatal pharmacogenetic disorder manifested as a life threatening hypermetabolic crisis in susceptible individuals following exposure to inhalation anesthetics and to depolarizing muscle relaxants. The... -
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- DA-6034 Induces [Ca2+]i Increase in Epithelial Cells
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Yang YM, Park S, Ji H, Kim TI, Kim EK, Kang KK, Shin DM
- KMID: 2285496
- Korean J Physiol Pharmacol.
- 2014 Apr;18(2):89-94.
- doi: 10.4196/kjpp.2014.18.2.89
DA-6034, a eupatilin derivative of flavonoid, has shown potent effects on the protection of gastric mucosa and induced the increases in fluid and glycoprotein secretion in human and rat corneal... -
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- Protein tyrosine phosphatase 1B is a mediator of cyclic ADP ribose-induced Ca²⺠signaling in ventricular myocytes
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Park SA, Hong BZ, Ha KC, Kim UH, Han MK, Kwak YG
- KMID: 2386961
- Exp Mol Med.
- 2017 Jun;49(6):e341.
- doi: 10.1038/emm.2017.68
Cyclic ADP-ribose (cADPR) releases Ca²⺠from ryanodine receptor (RyR)-sensitive calcium pools in various cell types. In cardiac myocytes, the physiological levels of cADPR transiently increase the amplitude and frequency of... -
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