- DNAse I hypersensitive sites of lung specific transcription factor gene
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Lee YC
- KMID: 2160239
- Tuberc Respir Dis.
- 2000 Jun;48(6):879-886.
- doi: 10.4046/trd.2000.48.6.879
BACKGROUND: Thyroid Transcription Factor-1(TTF-1) acts as a tissue specific transcription factor in the regulation of lung specific gene expression and as morphogenic protein during lung organogenesis. Currently, there is very... -
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- Calibrating Thresholds to Improve the Detection Accuracy of Putative Transcription Factor Binding Sites
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Kim YJ, Ryu GM, Park C, Kim KW, Oh B, Kim YY, Gu MB
- KMID: 2166271
- Genomics Inform.
- 2007 Dec;5(4):143-151.
To understand the mechanism of transcriptional regulation, it is essential to detect promoters and regulatory elements. Various kinds of methods have been introduced to improve the prediction accuracy of regulatory... -
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- Genetic Architecture of Transcription and Chromatin Regulation
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Kim K, Bang H, Lee K, Choi JK
- KMID: 2009145
- Genomics Inform.
- 2015 Jun;13(2):40-44.
- doi: 10.5808/GI.2015.13.2.40
DNA microarray and next-generation sequencing provide data that can be used for the genetic analysis of multiple quantitative traits such as gene expression levels, transcription factor binding profiles, and epigenetic... -
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- Genomic structure of the regulatory region of the voltage-gated calcium channel alpha 1D
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Kim HL, Chang YJ, Lee SM, Hong YS
- KMID: 755016
- Exp Mol Med.
- 1998 Dec;30(4):246-251.
In excitable and endocrine organs, calcium influxes through the L-type voltage-gated calcium channel (VGCC) which is composed of four (alpha 1, alpha 2, beta, and gamma) subunits. Temporal and spatial... -
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- Nuclear protein binding patterns in the 5'-upstream regulatory elements of HLA class I genes
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Park JH, Kim JD, Kim SJ
- KMID: 1728914
- Yonsei Med J.
- 1994 Sep;35(3):295-307.
- doi: 10.3349/ymj.1994.35.3.295
The expression of MHC class I genes has been thought to be regulated by two major cis-acting regulatory elements. The first region, enhancer A (Enh A) spanning from positions -210... -
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- Comparison of HPV 16 Sequence Variations at Upstream Regulatory Region in the Couples of Patients with Cervical Cancer for Determination of HPV Infectivity
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Kim JW, Song YS, Jeon HW, Park NH, Kang SB, Lee HP
- KMID: 2175238
- J Korean Cancer Assoc.
- 1999 Apr;31(2):403-410.
PURPOSE: Although it is now generally accepted that human papillomaviruses (HPVs) are causally related to cervical neoplasia by plentiful epidemioiogic and experimental works, little is known about the direct evidence... -
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- Association of Polymorphic Regulatory Region of TIGR Gene with Glaucoma
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Koo HJ, Son S, Kee C
- KMID: 2205978
- J Korean Ophthalmol Soc.
- 2001 Mar;42(3):519-526.
PURPOSE: To identify the polymorphism in the regulatory region of trabecular meshwork inducible glucocorticoid response(TIGR) gene and evaluate the association of it with glaucoma. METHODS: 5'regulatory region of TIGR gene... -
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- Understanding Epistatic Interactions between Genes Targeted by Non-coding Regulatory Elements in Complex Diseases
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Sung MK, Bang H, Choi JK
- KMID: 2391494
- Genomics Inform.
- 2014 Dec;12(4):181-186.
- doi: 10.5808/GI.2014.12.4.181
Genome-wide association studies have proven the highly polygenic architecture of complex diseases or traits; therefore, single-locus-based methods are usually unable to detect all involved loci, especially when individual loci exert... -
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- Adrenergic Genetic Mechanisms in Hypertension and Hypertensive Kidney Disease
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Kang SW
- KMID: 2168397
- Electrolyte Blood Press.
- 2013 Jun;11(1):24-28.
- doi: 10.5049/EBP.2013.11.1.24
Catecholamine secretory traits were significantly heritable, as were stress-induced blood pressure changes. Tyrosine hydroxylase (TH) is the rate-limiting enzyme in catecholamine biosynthesis. In the tyrosine hyroxylase promoter, significant associations were... -
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- Gene Regulatory Regions Required for beta Defensin-2 Up-Regulation by Interleukin-1alpha in the Human Middle Ear Epithelial Cell Line
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Kim HJ, Bae JH, Choung YH, Park K, Moon SK
- KMID: 1597332
- Korean J Otolaryngol-Head Neck Surg.
- 2005 May;48(5):577-581.
BACKGROUND AND OBJECTIVES: Innate immunity is important in the middle ear because of the lack of immune cells in the region. Among innate immunities beta-defensin-2 is known to play an... -
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- Association of MCP-1 polymorphism with cardiovascular disease risk factors in Korean elderly
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Park HJ
- KMID: 2327131
- J Nutr Health.
- 2013 Dec;46(6):511-520.
Monocyte chemoattractant protein-1 (MCP-1) plays an important role in cardiovascular disease (CVD). Genetic polymorphism in the regulatory regions of MCP-1 could affect MCP-1 expression. The purpose of the study was... -
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- Transcriptional Mechanisms of Drug Addiction
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Nestler EJ
- KMID: 1432535
- Clin Psychopharmacol Neurosci.
- 2012 Dec;10(3):136-143.
- doi: 10.9758/cpn.2012.10.3.136
Regulation of gene expression is considered a plausible mechanism of drug addiction given the stability of behavioral abnormalities that define an addicted state. Numerous transcription factors, proteins that bind to... -
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- Sequence Variation in The Upstream Regulatory Region of Human Papillomavirus Type 16 isolated from The Uterine Cervix in Korean Women
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Jeon HW, Lee HP
- KMID: 2260919
- Korean J Obstet Gynecol.
- 1998 Apr;41(4):1087-1104.
It is widely accepted that human papillomaviruses (HPV), especially type 16 and type 18 are the primary causal agent for the development of invasive cervical cancer and its precursor lesions.... -
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- Serotonin Transporter Gene Polymorphism and Major Depression
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Lim SW, Sohn SE, Kim DK, Kim E
- KMID: 2340426
- J Korean Neuropsychiatr Assoc.
- 2000 Jan;39(1):199-207.
OBJECTIVE: Serotonin transporter(5-hydroxytryptamine transporter, 5-HTT) plays a critical role in the termination of serotonergic neurotransmission into the presynaptic neuron and represents an initial site of uptake inhibiting antidepressants, including tricyclic... -
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- An Association Study of the Impulsiveness and Aggressiveness in Adolescent Prisoners with Serotonin Transporter Gene Promoter Region Polymorphism
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Lee JH, Kim HT, Joe KH
- KMID: 2340988
- J Korean Neuropsychiatr Assoc.
- 2004 Mar;43(2):183-188.
OBJECTIVES: This study was carried out to explore the relationship between the impulsiveness and aggressiveness in adolescent prisoners and a polymorphism of the promoter region of the 5-HTT gene (5HTTLPR). METHODS:... -
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- Serotonin Transporter Gene Polymorphsims and Its Phenotypic Characteristics Expressed in Platelet [3H]-Serotonin Uptake Study in Korean Depressed Patients
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Kim DK, Seo MY, Lim SW, Kim H, Kim S
- KMID: 2196858
- J Korean Neuropsychiatr Assoc.
- 2003 Jan;42(1):54-60.
OBJECTIVES: Serotonin transporter (5-HTT) is a key synaptic regulator of serotonergic neurotransmission and a major site of action of serotonin selective reuptake inhibitors (SSRIs) such as fluoxetine or paroxetine. Two... -
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- Serotonin Transporter Gene Polymorphisms and Harm Avoidance Personality in Chronic Tension Type Headache and Migraine
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Park JW, Kim JS, Kim YI, Lee KS
- KMID: 2343138
- J Korean Neurol Assoc.
- 2005 Apr;23(2):181-185.
BACKGROUND: Serotonin transporter protein (5-HTT) is a key modulating protein in synaptic serotonergic neurotransmission. Among serotonin gene-linked polymorphism, the promoter, located in the regulatory region of the 5-HTT gene linked... -
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- Role of Sp Family Transcription Factors in Growth Hormone Receptor Gene Expression
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Shin JW, Yu JH, An RZ
- KMID: 2001521
- J Korean Soc Pediatr Endocrinol.
- 2000 Dec;5(2):151-162.
PURPOSE: The growth hormone receptor(GHR) is essential for the actions of growth hormone on postnatal growth and metabolism. GHR transcripts are characterized by the presence of disparate 5'untranslated exons. In... -
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- Identification of Causal and/or Rare Genetic Variants for Complex Traits by Targeted Resequencing in Population-based Cohorts
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Kim YK, Hong CB, Cho YS
- KMID: 2284667
- Genomics Inform.
- 2010 Sep;8(3):131-137.
Genome-wide association studies (GWASs) have greatly contributed to the identification of common variants responsible for numerous complex traits. There are, however, unavoidable limitations in detecting causal and/or rare variants for... -
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- The Effects of Polymorphism in the MCP-1 Gene Regulatory Region on MCP-1 Expression and the Manifestation of Lupus Nephritis
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Kim HL, Yang SH, Oh YK, Lee JE, Oh JE, Yoon HJ, Kim YS, Ahn CR, Han JS, Kim SG, Lee JS
- KMID: 2254465
- Korean J Nephrol.
- 2002 Jan;21(1):137-144.
BACKGROUND: Monocyte chemoattractant protein- 1(MCP-1) plays an important role in progression of lupus nephritis.(LN) The genetic polymorphism in the regulatory region would influence clinical manifestations by controlling serum levels of... -
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