- Innate Immunity and Toll Like Receptors
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Kim KH
- KMID: 2140971
- Korean J Pediatr.
- 2004 Jan;47(1):6-11.
The innate immune system is essential for host defense and is responsible for early detection of pathogenic microorganisms. Whereas the structure of microbial compounds has been extensively studied, the molecular... -
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- Damage-Associated Molecular Patterns in Inflammatory Diseases
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Roh JS, Sohn DH
- KMID: 2419772
- Immune Netw.
- 2018 Aug;18(4):e27.
- doi: 10.4110/in.2018.18.e27
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although... -
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- The in vivo and in vitro Roles of Epithelial Pattern Recognition Receptors in Pneumococcal Infections
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Shin SG, Koh SH, Lim JH
- KMID: 2168687
- J Bacteriol Virol.
- 2014 Jun;44(2):121-132.
- doi: 10.4167/jbv.2014.44.2.121
Streptococcus pneumoniae, also called pneumococcus, is a major cause of infectious disease in human. Pneumococcus resides in the nasopharynx as an upper respiratory commensal, and most of pneumococcal colonizations are... -
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- The Innate Immune Responses in Pathogenesis of Chronic Rhinosinusitis
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Mo JH
- KMID: 2146667
- J Rhinol.
- 2014 May;21(1):22-27.
- doi: 10.0000/jr.2014.21.1.22
Chronic rhinosinusitis (CRS) is a multifactorial and heterogeneous disease, and variousfactors, such as inflammation, infection, fungus, and superantigens, have been proposed to play crucial roles in its pathogenesis. Recently, the... -
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- PKR as a Regulator of Inflammasome Activation
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Manzoor Z, Koh YS
- KMID: 2168684
- J Bacteriol Virol.
- 2013 Jun;43(2):145-147.
- doi: 10.4167/jbv.2013.43.2.145
Detection of pathogen by pattern recognition receptors leads to activation of inflammasome which plays a crucial role in immune system. The inflammasome regulates the release of cytokines, such as interleukin... -
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- Toll-Like Receptor Ligands as Cancer Immunotherapeutics
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Lee SE, Rhee JH
- KMID: 1434755
- J Bacteriol Virol.
- 2012 Sep;42(3):255-262.
- doi: 10.4167/jbv.2012.42.3.255
Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) expressed in a wide spectrum of cell types that recognize distinctive ligands and subsequently activate adaptive immune responses. TLR ligands are considered... -
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- Clinical Approaches for Understanding the Expression Levels of Pattern Recognition Receptors in Otitis Media with Effusion
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Lee SY, Ryu EW, Kim JB, Yeo SG
- KMID: 2166395
- Clin Exp Otorhinolaryngol.
- 2011 Dec;4(4):163-167.
OBJECTIVES: Bacterial infections in the normally sterile environment of the middle ear cavity usually trigger host immune response, whereby the innate immune system plays a dominant role as the host's... -
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- NOD-Like Receptors in Infection, Immunity, and Diseases
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Kim YK, Shin JS, Nahm MH
- KMID: 2466346
- Yonsei Med J.
- 2016 Jan;57(1):5-14.
- doi: 10.3349/ymj.2016.57.1.5
Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are pattern-recognition receptors similar to toll-like receptors (TLRs). While TLRs are transmembrane receptors, NLRs are cytoplasmic receptors that play a crucial role in... -
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- Basic and Translational Understandings of Microbial Recognition by Toll-Like Receptors in the Intestine
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Rhee SH
- KMID: 2326186
- J Neurogastroenterol Motil.
- 2011 Jan;17(1):28-34.
Microbial recognition by multicellular organisms is initially accomplished by a group of pattern recognition receptors which are specialized to recognize microbe-associated molecular patterns (MAMPs) such as lipopolysaccharide, bacterial lipoprotein, CpG... -
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- Role of Type I Interferon during Bacterial Infection
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Min CK, Choi MS, Kim IS, Cho NH
- KMID: 1737324
- J Bacteriol Virol.
- 2014 Dec;44(4):352-358.
- doi: 10.4167/jbv.2014.44.4.352
Type 1 Interferons (T1 IFN) play a pivotal role in innate immune responses against viral infection. Recently, this anti-viral cytokines are shown to be induced during bacterial infections via activation... -
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- Dual Effect of Hepatic Macrophages on Liver Ischemia and Reperfusion Injury during Liver Transplantation
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Lu TF, Yang TH, Zhong CP, Shen C, Lin WW, Gu GX, Xia Q, Xu N
- KMID: 2414553
- Immune Netw.
- 2018 Jun;18(3):e24.
- doi: 10.4110/in.2018.18.e24
Ischemia-reperfusion injury (IRI) is a major complication in liver transplantation (LT) and it is closely related to the recovery of grafts' function. Researches has verified that both innate and adaptive... -
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- Sensing DNA Viruses and Bacteria by Intracellular DNA Sensors
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Lee NR, Shin HB, Kim HI, Choi MS, Inn KS
- KMID: 2168676
- J Bacteriol Virol.
- 2013 Jun;43(2):77-84.
- doi: 10.4167/jbv.2013.43.2.77
The innate immune system confers first-line defense against various pathogens including bacteria and viruses. Early detection of invading pathogens by the host depends on a limited number of specific pattern... -
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- The Cockroach and Allergic Diseases
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Sohn MH, Kim KE
- KMID: 2167044
- Allergy Asthma Immunol Res.
- 2012 Sep;4(5):264-269.
- doi: 10.4168/aair.2012.4.5.264
The cockroach represents one of the most common sources of indoor allergens worldwide, and 40%-60% of patients with asthma in urban and inner-city areas possess IgE antibodies to cockroach allergens.... -
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- Generation of Tolerogenic Dendritic Cells and Their Therapeutic Applications
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Yoo S, Ha SJ
- KMID: 2154811
- Immune Netw.
- 2016 Feb;16(1):52-60.
- doi: 10.4110/in.2016.16.1.52
Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that bridge innate and adaptive immune responses, thereby leading to immune activation. DCs have been known to recognize pathogen-associated molecular patterns such... -
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- Cellular and Molecular Mediators of Neuroinflammation in Alzheimer Disease
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Yang SH
- KMID: 2467313
- Int Neurourol J.
- 2019 Nov;23(Suppl 2):S54-S62.
- doi: 10.5213/inj.1938184.092
Alzheimer disease (AD) is a neurodegenerative disorder characterized by the loss of neuronal cells and the progressive decline of cognitive function. The major pathological culprit of AD is aggregation of... -
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- Effector Pathways of Toll-like Receptor-inducible Innate Immune Responses in Macrophages
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Jo EK, Suh HW, Park JK
- KMID: 2442584
- J Bacteriol Virol.
- 2019 Mar;49(1):12-26.
- doi: 10.4167/jbv.2019.49.1.12
Toll-like receptors (TLR) are well-characterized pattern recognition receptors that can recognize and respond to diverse pathogen-associated or danger-associated molecular patterns during infection. TLR signaling in macrophages triggers in the intracellular... -
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- Inflammasomes, multi-cellular protein complex in myeloid cells, induce several metabolic diseases via interleukin-1beta maturation
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Lee GS
- KMID: 1703511
- J Biomed Res.
- 2013 Dec;14(4):195-200.
Inflammation mainly mediated by innate immune cells as the first line of host defense against pathogens is an acute response that limits tissue damage and eliminates pathogens in the body.... -
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- Toll-like Receptor 2: A Novel Therapeutic Target for Ischemic White Matter Injury and Oligodendrocyte Death
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Choi JY, Kim BG
- KMID: 2389005
- Exp Neurobiol.
- 2017 Aug;26(4):186-194.
- doi: 10.5607/en.2017.26.4.186
Despite paramount clinical significance of white matter stroke, there is a paucity of researches on the pathomechanism of ischemic white matter damage and accompanying oligodendrocyte (OL) death. Therefore, a large... -
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- A Decade of Research on TLR2 Discovering Its Pivotal Role in Glial Activation and Neuroinflammation in Neurodegenerative Diseases
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Hayward JH, Lee SJ
- KMID: 2165514
- Exp Neurobiol.
- 2014 Jun;23(2):138-147.
- doi: 10.5607/en.2014.23.2.138
Toll-like receptors (TLRs) belong to a class of pattern recognition receptors that play an important role in host defense against pathogens. TLRs on innate immune cells recognize a wide variety... -
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- Regulatory Roles of the Caspase-11 Non-Canonical Inflammasome in Inflammatory Diseases
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Yi YS
- KMID: 2429833
- Immune Netw.
- 2018 Dec;18(6):e41.
- doi: 10.4110/in.2018.18.e41
Inflammation is an immune response mediated by innate immune cells of tissues, against invading microbes and cellular stress. The hallmark of inflammatory responses is the activation of inflammasomes — multiprotein... -
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