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The effects of nalbuphine and fentanyl on experimental spinal cord injuries

Lee WH

Opiate receptor agonists (especially dynorphin - a kappa receptor agonist) have found to increase in the injuried segment of spinal cord. It is known to cause spinal cord damage when...
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Roles of Opioid Receptor Subtype in the Spinal Antinociception of Selective Cyclooxygenase 2 Inhibitor

Choi CH, Kim WM, Lee HG, Jeong CW, Kim CM, Lee SH, Yoon MH

BACKGROUND: Selective inhibitors of cyclooxygenase (COX)-2 are commonly used analgesics in various pain conditions. Although their actions are largely thought to be mediated by the blockade of prostaglandin (PG) biosynthesis,...
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The Effects of Peripheral mu and kappa Opioid Receptor Agonists on the Thermal Injury Induced Hyperalgesia in the Rat

Chun YS, Jun JH, Shim JC, Kim KS, Suh JK, Yoo HK, Seung IS

BACKGROUND: Previous reports have described that the local administration of opioid receptor agonist can attenuate the nociceptive responses induced by a variety of inflammatory states. This study evaluated the effects...
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Dual effect of dynorphin A on single-unit spike potentials in rat trigeminal nucleus

Lee KM, Han HS, Jang JH, Ahn DK, Park JS

  • KMID: 1606936
  • Korean J Physiol Pharmacol.
  • 2001 Jun;5(3):213-221.
The amygdala is known as a site for inducing analgesia, but its action on the trigeminal nucleus has not been known well. Little information is available on the effect of dynorphin on...
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The Effects of Pre-emptive Administration of Ketamine and norBNI on Pain Behavior, c-Fos, and Prodynorphin Protein Expression in the Rat Spinal Cord after Formalin-induced Pain Is Modulated by the DREAM Protein

Long I, Suppian R, Ismail Z

BACKGROUND: We investigated the effects of pre-emptive administration of ketamine and norBNI on pain behavior and the expression of DREAM, c-Fos, and prodynorphin proteins on the ipsilateral side of the...
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