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Synthesis and Evaluation of 2-[18F]Fluoro-A85380 , a Radioligand for alpha4beta2 Nicotinic Acetylcholine Receptor Imaging

Ryu EK, Choe YS, Kim SE, Hwang SH, Paik JY, Choi Y, Lee KH, Kim BT

  • KMID: 1613820
  • Korean J Nucl Med.
  • 2002 Aug;36(4):261-270.
No abstract available.
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"Neuronal-like" Properties of Urothelium in Bladder

Kim JC

No abstract available.
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Quantitative Structure Activity Relationship between Diazabicyclo[4.2.0]octanes Derivatives and Nicotinic Acetylcholine Receptor Agonists

Kim EA, Jung KC, Sohn UD, Im C

Three dimensional quantitative structure activity relationship between diazabicyclo[4.2.0]octanes and nicotinic acetylcholine receptor (h alpha4beta2 and h alpha3beta4) agonists was studied using comparative molecular field analysis (CoMFA) and comparative molecular similarity...
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Role of Nicotinic Acetylcholine Receptor on Efferent Inhibition in Cochlear Hair Cell

Im GJ

The alpha9alpha10 nicotinic acetylcholine receptors (nAChRs) mediates efferent inhibition of hair cell function within the auditory sensory organ. Gating of the nAChRs leads to activation of calcium-dependent potassium channels to...
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Characteristics of Nicotinic Receptor Expressed in Human Retinoblastoma

Kim DR, Cha SK, Kong ID, Jung SH, Rah SH

  • KMID: 2126199
  • J Korean Ophthalmol Soc.
  • 2005 Jun;46(6):1060-1067.
PURPOSE: To identify the characteristics and physiological function of the nicotinic receptor expressed in human retinoblastoma cells. METHODS: We measured possible nicotinic signaling in WERI-Rb-1 cells using the Ca2+ imaging...
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Quercetin Inhibits alpha3beta4 Nicotinic Acetylcholine Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes

Lee BH, Hwang SH, Choi SH, Shin TJ, Kang J, Lee SM, Nah SY

  • KMID: 2389104
  • Korean J Physiol Pharmacol.
  • 2011 Feb;15(1):17-22.
Quercetin mainly exists in the skin of colored fruits and vegetables as one of flavonoids. Recent studies show that quercetin, like other flavonoids, has diverse pharmacological actions. However, relatively little...
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Cytisine, a Partial Agonist of α4β2 Nicotinic Acetylcholine Receptors, Reduced Unpredictable Chronic Mild Stress-Induced Depression-Like Behaviors

Han J, Wang DS, Liu SB, Zhao MG

Cytisine (CYT), a partial agonist of α4β2-nicotinic receptors, has been used for antidepressant efficacy in several tests. Nicotinic receptors have been shown to be closely associated with depression. However, little...
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Inhibitory Effects of Quercetin on Muscle-type of Nicotinic Acetylcholine Receptor-Mediated Ion Currents Expressed in Xenopus Oocytes

Lee BH, Shin TJ, Hwang SH, Choi SH, Kang J, Kim HJ, Park CW, Lee SH, Nah SY

The flavonoid quercetin is a low molecular weight compound generally found in apple, gingko, tomato, onion and other red-colored fruits and vegetables. Like other flavonoids, quercetin has diverse pharmacological actions....
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Neurobiological Mechanism of Nicotine Dependence

Yoon SJ, Kim DJ

  • KMID: 2286799
  • Korean J Psychopharmacol.
  • 2005 Sep;16(5):351-360.
Nicotine, the primary psychoactive components of tobacco smoke, produce diverse neurophysiological and behavioral effects through several brain regions and neurochemical pathways. It acts as an agonist to activate and desensitize...
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Acute Respiratory Failure and Hypotension with Acute Imidacloprid Poisoning

Ha MS, Min JH, Kim H, Lee SW, Park JS

  • KMID: 2332907
  • J Korean Soc Emerg Med.
  • 2011 Apr;22(2):184-187.
Imidacloprid belongs to a relatively new class of insecticides, chloronicotinyl neonicotinoid compounds that are agonists of insect postsynaptic nicotinic acetylcholine receptors (nAChrs). Imidacloprid insecticides have been believed to be of...
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Influence of Total Ginseng Saponin on the Blood Pressure of the Rat

Lim DY, Park KB, Kim KH, Moon JK, Lee KS, Kim YK, Chung YH, Hong SP

This study is an attempt to investigate the effect of total Ginseng saponin (GTS) on the blood pressure of the rat and to elucidate its mechanism of action. GTS, when...
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Effects of Vecuronium and Pancuronium on the Tension of the Smooth Muscle in the Rat Trachea

Kim SS, Son YS, Kim YH, Yoon SH, Lee JU, Kim HJ

BACKGROUND: Vecuronium and Pancuronium have been proven to be associated with nicotinic receptor of skeletal muscle. Generally, nondepolarizing muscle relaxant is associated with contraction of smooth tracheal muscle, but there...
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Melatonin inhibits nicotinic acetylcholine receptor functions in bovine chromaffin cells

Jo SH, Lee SH, Kim KT, Choi SY

Melatonin is a neurotransmitter that modulates various physiological phenomena including regulation and maintenance of the circadian rhythm. Nicotinic acetylcholine receptors (nAChRs) play an important role in oral functions including orofacial...
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Studies on the Interactions of M1-, M2- Receptors with Nicotinic Receptors in Rabbit Sympathetic Ganglia

Ryu CS, Kang SS, Lee JH, Kim JK

  • KMID: 2044418
  • J Korean Neurosurg Soc.
  • 1994 Nov;23(11):1234-1243.
Effects of a M1 receptor antagonist, pirenzepine, a M2 receptor antagonist, AF-DX116, and a nicotinic receptor antagonist, mecamylamine on the pressor responses to preganglionic sympathetic nerve stimulation(PNS) and McN-A-343 and...
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Spinal anesthesia for cesarean section in a patient with myasthenia gravis : A case report

Cho HY, Shin YS, Jo WH

  • KMID: 2263357
  • Anesth Pain Med.
  • 2009 Jan;4(1):47-49.
Myasthenia gravis, an autoimmune disease with antibodies directed against the nicotinic acetylcholine receptor, is relatively common in young women and sometimes associated with pregnancy. Because pregnancy can influence myasthenia gravis...
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Smoking as an Addictive Disorder

Joe KH, Kim DJ

  • KMID: 2341546
  • J Korean Neuropsychiatr Assoc.
  • 2009 Jul;48(4):213-219.
Nicotine is the major substance that accounts for the addictive nature of smoking. Nicotine induces neurobiological and behavioral responses through diverse neurochemical mechanisms over the central nervous system. The brain...
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The role of spinal adrenergic receptors on the antinociception of ginsenosides in a rat postoperative pain model

Kim IJ, Park CH, Lee SH, Yoon MH

BACKGROUND: The effect of spinal adrenergic and cholinergic receptors on the anti-nociceptive effect of intrathecal ginsenosides was determined in a rat postoperative pain model. METHODS: Catheters were placed into the intrathecal...
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Antidote for organophosphate insecticide poisoning: atropine and pralidoxime

Chung SP, Roh HK

Acute organophosphate (OP) poisoning produces cholinergic symptoms resulting from the inhibition of cholinesterase, and the overstimulation of muscarinic and nicotinic receptors in the synapses. The dominant clinical features of acute...
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Neuregulins Action and Signaling Pathway in the Nervous System

Woo RS

  • KMID: 1484900
  • Korean J Anat.
  • 2008 Jun;41(2):105-110.
The neuregulins (NRGs) are a family of proteins containing an epidermal growth factor (EGF)-like motif that mediates important functions not only in the nervous system but also in the heart,...
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Effect of Spinal Adrenergic and Cholinergic Antagonists for Antinociception of Intrathecal Gabapentin

Yoon MH, Chung SS, Kim HS

BACKGROUND: Intrathecal gabapentin is effective on nociceptive states evoked by tissue injury. In addition, gabapentin interacts synergistically with clonidine at the spinal level, suggesting that a mechanism of gabapentin...
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