- MUC2/5AC Expression and Mucin Secretion through Leukotriene Receptor in Human Airway Epithelial Cells
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Kim YD, Lee JE, Bai CH, Seo YJ, Ye SB, Song SY
- KMID: 2276273
- Korean J Otolaryngol-Head Neck Surg.
- 2004 Nov;47(11):1115-1119.
BACKGROUND AND OBJECTIVES: Mucin gene expression and mucin production are highly increased during inflammatory airway disorders such as, asthma, chronic bronchitis and sinusitis. Cytokines, lipopolysaccharides and other inflammatory mediators are... -
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- Association of Leukotriene C4 Synthase Gene Polymorphism with Clinical Response to Montelukast in Childhood Asthma
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Shin KS, Kim YW
- KMID: 1855968
- Korean J Pediatr.
- 2005 Jul;48(7):766-771.
PURPOSE: Cysteinyl leukotrienes are important inflammatory mediators in the pathogenesis of asthma; therefore interruption of cysteinyl leukotrienes by leukotriene receptor antagonists improves clinical symptoms in the management of patients with... -
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- Pharmacogenomic Approaches to Asthma Treatment
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Cho SH
- KMID: 2133805
- Allergy Asthma Immunol Res.
- 2010 Jul;2(3):177-182.
- doi: 10.4168/aair.2010.2.3.177
Major classes of medication in asthma management include bronchodilating beta2-agonists, anti-inflammatory inhaled corticosteroids, leukotriene modifiers and theophyllines. However, all asthmatics do not respond to the same extent to a given... -
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- Effect of Inhaled Corticosteroid and Leukotriene Receptor Antagonist in Cough-variant Asthma Patients under Five Years of Age
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Jung JA
- KMID: 2314386
- Pediatr Allergy Respir Dis.
- 2005 Sep;15(3):263-269.
PURPOSE: Cough-variant asthma (CVA) is a common cause of chronic cough in young children. Some children who have CVA eventually develop classic asthma. We evaluated the effect of inhaled corticosteroid... -
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- MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage
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Lee AJ, Cho KJ, Kim JH
- KMID: 2070275
- Exp Mol Med.
- 2015 Apr;47(4):e156.
- doi: 10.1038/emm.2015.8
Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macrophages. The detailed mechanism of IL-6... -
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- Leukotriene B(4) receptor 2 gene polymorphism (rs1950504, Asp196Gly) leads to enhanced cell motility under low-dose ligand stimulation
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Jang JH, Wei JD, Kim M, Kim JY, Cho AE, Kim JH
- KMID: 2396807
- Exp Mol Med.
- 2017 Nov;49(11):e402.
- doi: 10.1038/emm.2017.192
Recently, single-nucleotide polymorphisms (SNPs) in G-protein-coupled receptors (GPCRs) have been suggested to contribute to physiopathology and therapeutic effects. Leukotriene B4 receptor 2 (BLT2), a member of the GPCR family, plays... -
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- The Effects of Anti-histamine and Leukotriene Receptor Antagonist Against Ischemia-Reperfusion Injury
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Cho HI, Chang H, Kim SW
- KMID: 2321174
- J Korean Soc Microsurg.
- 2012 May;21(1):61-67.
PURPOSE: The purpose of this study was to investigate the role of mast cells and their product, histamine and leukotriene in ischemia-reperfusion injury. METHODS: Forty Sprague-Dawley rats were divided into four... -
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- Association study of polymorphism in leukotriene C4 synthase and cysteinyl leukotriene receptor 1 genes with phenotype of asthma and clinical parameters in Korean children
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Shim JY, Kim BJ, Song YH, Kang MJ, Lee SY, Kim HB, Yu J, Hong SJ
- KMID: 2281073
- Korean J Pediatr.
- 2009 Jun;52(6):680-688.
- doi: 10.3345/kjp.2009.52.6.680
PURPOSE: Cysteinyl leukotrienes are important proinflammatory mediators in asthma. Recently, it was suggested that a promoter polymorphism in the genes encoding for leukotriene C4 synthase (LTC4S), a key enzyme in... -
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- Leukotriene B4 pathway regulates the fate of the hematopoietic stem cells
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Chung JW, Kim GY, Mun YC, Ahn JY, Seong CM, Kim JH
- KMID: 1033100
- Exp Mol Med.
- 2005 Feb;37(1):45-50.
Leukotriene B4(LTB4), derived from arachidonic acid, is a potent chemotactic agent and activating factor for hematopoietic cells. In addition to host defense in vivo, several eicosanoids have been reported to... -
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- The Efficacy of a Leukotriene Receptor Antagonist and a Second-generation Anti-histamine in the Treatment for Children with Moderate to Severe Persistent Allergic Rhinitis
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An HS, Kang TG, Kim JE, Lee YS, Lee JS, Jung JA
- KMID: 2314879
- Pediatr Allergy Respir Dis.
- 2008 Jun;18(2):158-166.
PURPOSE: We evaluated the efficacy of leukotriene receptor antagonist and second generation anti-histamine in children with moderate to severe persistent allergic rhinitis. METHODS: Twenty eight patients who were treated with second... -
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- The Effects of Leukotriene Receptor Antagonist on Nasal Mucous Membrane in Allergic Model of Guinea Pigs
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Yu MS, Lee JH, Park JK, Lee JD, Kim DW, Lee BD, Chang HS, Cho JS
- KMID: 2115454
- Korean J Otolaryngol-Head Neck Surg.
- 2003 Dec;46(12):1028-1034.
BACKGROUND AND OBJECTIVES: The leukotriene (LT) receptor antagonist is subject to an on-going study of allergic rhinitis, nasal polyposis and chronic paranasal sinusitis. This study was designed to evaluate the... -
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- Successful desensitization of a patient with albumin hypersensitivity
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Jung SY, Choi YJ, Lee SH, Kang HR, Suh DI
- KMID: 2392384
- Allergy Asthma Respir Dis.
- 2017 Mar;5(2):117-120.
- doi: 10.4168/aard.2017.5.2.117
There have been few cases of albumin hypersensitivity reported, and there is limited information on this condition. When a patient is anaphylactic to a certain drug and no alternative drug... -
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- Add-on Therapy for Symptomatic Asthma despite Long-Acting Beta-Agonists/Inhaled Corticosteroid
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Dreher M, Müller T
- KMID: 2420585
- Tuberc Respir Dis.
- 2018 Jan;81(1):1-5.
- doi: 10.4046/trd.2017.0102
Asthma, remains symptomatic despite ongoing treatment with high doses of inhaled corticosteroids (ICS) in conjunction with long-acting beta-agonists (LABA), is classified as “severe†asthma. In the course of caring for... -
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- Clinical effect of montelukast in exercise-induced asthma
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Kim JH, Min UK, Choi SO, Lee SG, Hong SJ
- KMID: 2285868
- J Asthma Allergy Clin Immunol.
- 2002 Dec;22(4):720-727.
BACKGROUND: Patients with bronchial asthma frequently have exercise-induced bronchocon striction. Exercise-induced bronchoconstriction limits the activities important for physical and social development in children. Leukotriene receptor antagonist has been shown to... -
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- Protection of leukotriene receptor antagonist against aspirin-induced bronchospasm in asthmatics
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Park JS, Jang AS, Park SW, Lee YM, Uh ST, Kim YH, Cha JY, Park SM, Park CS
- KMID: 2260419
- Allergy Asthma Immunol Res.
- 2010 Jan;2(1):48-54.
- doi: 10.4168/aair.2010.2.1.48
PURPOSE: Leukotriene receptor antagonists (LTRAs) are used to treat aspirin-intolerant asthma (AIA); however, the protective effects of long-term LTRA administration against aspirin-induced bronchospasm have not been evaluated. OBJECTIVES: We investigated the... -
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- The effect of ONO-1078 (Pranlukast hydrate), a leukotriene-receptor antagonist, for the treatment of moderate to severe asthmatics with chronic rhinosinusitis
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Lee SP, Lim YH, Lee BJ, Choi DC
- KMID: 1850956
- J Asthma Allergy Clin Immunol.
- 2000 Aug;20(4):593-600.
BACKGROUND AND OBJECTIVE: The cysteinyl leukotrienes are bioactive lipid mediators that contribute to the pathophysiologic condition of asthma and rhinosinusitis. We tested whether the leukotriene receptor antagonist ONO-1078 (Pranukast) had... -
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- A Double-Blind, Randomized, Crossover Study to Compare the Effectiveness of Montelukast on Atopic Dermatitis in Korean Children
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Jeon YH, Min TK, Yang HJ, Pyun BY
- KMID: 2165913
- Allergy Asthma Immunol Res.
- 2016 Jul;8(4):305-311.
- doi: 10.4168/aair.2016.8.4.305
PURPOSE: Some studies report a role of leukotrienes in the pathogenesis of atopic dermatitis and suggest a rationale for the use of leukotriene receptor antagonist (LTRA) in the treatment of... -
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- Leukotriene related gene polymorphisms in ASA-intolerant asthma: an association of 5-lipoxygenase haplotype
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Choi JH, Park HS, Shin SS, Oh HB, Lee JH, Suh YJ, Park CS, Shin HD
- KMID: 2178419
- J Asthma Allergy Clin Immunol.
- 2003 Dec;23(4):800-809.
BACKGROUND AND OBJECTIVES: A recent study has demonstrated a possible involvement of leukotriene C4 synthase (LTC4S) gene polymorphism in ASA-intolerant asthma (AIA) in a Polish population, while no significances were... -
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- Therapeutic Effect of Combination Treatment of Antihistamine and Montelukast in Allergic Rhinitis
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Son HR, Lee KI, Chung YJ, Mo JH
- KMID: 2297561
- J Rhinol.
- 2013 May;20(1):20-25.
BACKGROUND: Montelukast is a type 1 cysteinyl-leukotrienes receptor antagonist that has been widely used in allergic disease. However, the effect of combination of leukotriene receptor antagonist and antihistamine is controversial.... -
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- Efficacy of a Combination with Pranlukast and Cetirizine in the Treatment of Allergic Rhinitis
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Kim DJ, Jeon SY, Kim JP, Ahn SK, Kim BG
- KMID: 2276214
- Korean J Otolaryngol-Head Neck Surg.
- 2004 Sep;47(9):863-867.
BACKGROUND AND OBJECTIVES: It has been suggested that the combination of a leukotriene receptor antagonist with an antihistamine may have beneficial effects in the treatment of allergic rhinitis. The aim... -
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