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New Frontiers in Pharmacology

Lee WC

No abstract available.
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A Case of Gitelman Syndrome

Han YJ, Yeon EK, Kim YC

  • KMID: 2317667
  • Soonchunhyang Med Sci.
  • 2012 Dec;18(2):145-147.
Gitelman's syndrome is an autosomal recessive disorder characterized by hypokalemic metabolic alkalosis, hypomagnesemia, and hypocalciuria that has recently been reported to be linked to thiazide-sensitive Na-Cl cotransporter gene mutation. We...
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SR144528 as Inverse Agonist of CB2 Cannabinoid Receptor

Rhee MH, Kim SK

  • KMID: 1095119
  • J Vet Sci.
  • 2002 Sep;3(3):179-184.
It is now well established that several G protein- coupled receptors can signal without agonist stimulation (constitutive receptors). Inverse agonists have been shown to inhibit the activity of such constitutive...
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Role of nociceptin/orphanin FQ and nociceptin opioid peptide receptor in depression and antidepressant effects of nociceptin opioid peptide receptor antagonists

Park JY, Chae S, Kim CS, Kim YJ, Yi HJ, Han E, Joo Y, Hong S, Yun JW, Kim H, Shin KH

Nociceptin/orphanin FQ (N/OFQ) and its receptor, nociceptin opioid peptide (NOP) receptor, are localized in brain areas implicated in depression including the amygdala, bed nucleus of the stria terminalis, habenula, and...
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Transient neonatal diabetes mellitus caused by a de novo ABCC8 gene mutation

Kong JH, Kim JB

Transient neonatal diabetes mellitus (TNDM) is a rare form of diabetes mellitus that presents within the first 6 months of life with remission in infancy or early childhood. TNDM is...
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Functional Role of Serine Residues of Transmembrane Dopamin VII in Signal Transduction of CB2 Cannabinoid Receptor

Rhee MH

  • KMID: 1095120
  • J Vet Sci.
  • 2002 Sep;3(3):185-191.
Using site-directed mutagenesis technique, I have replaced serine 285 and serine 292 with the alanine, and assessed the binding of agonist and signaling such as the inhibition of adenylyl cyclase...
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Angiotensin II AT1 Receptor Blockade Changes Expression of Renal Sodium Transporters in Rats with Chronic Renal Failure

Kim EJ, Jung YW, Kwon TH

We aimed to examine the effects of angiotensin II AT1 receptor blocker on the expression of major renal sodium transporters and aquaporin-2 (AQP2) in rats with chronic renal failure (CRF)....
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Increased Expression of Sodium Transporters in Rats Chronically Inhibited of Nitric Oxide Synthesis

Kim JS, Choi KC, Jeong MH, Kim SW, Oh YW, Lee JU

The present study was done to determine whether endogenous nitric oxide (NO) plays a role in the regulation of sodium transporters in the kidney. Male Sprague-Dawley rats were treated with...
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