- The role of spinal adrenergic receptors on the antinociception of ginsenosides in a rat postoperative pain model
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Kim IJ, Park CH, Lee SH, Yoon MH
- KMID: 1828069
- Korean J Anesthesiol.
- 2013 Jul;65(1):55-60.
- doi: 10.4097/kjae.2013.65.1.55
BACKGROUND: The effect of spinal adrenergic and cholinergic receptors on the anti-nociceptive effect of intrathecal ginsenosides was determined in a rat postoperative pain model. METHODS: Catheters were placed into the intrathecal... -
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- Modulation of Alpha 1 Adrenergic Receptors on Urinary Bladder in Rat Spinal Cord Injury Model
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Lee G, Park H, Park HS, Lee JG
- KMID: 2232829
- Int Neurourol J.
- 2012 Jun;16(2):62-68.
PURPOSE: Whereas many studies have focused on the vesical changes of the alpha1 adrenergic receptor (AR) subtypes in partial outlet obstruction, few studies have addressed the modulation of the alpha1... -
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- Preventive effects of prazosin for urinary retention after epidural anesthesia
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Park MS, Lee JH
- KMID: 2289314
- Korean J Urol.
- 1993 Dec;34(6):1043-1047.
Prazosin blocks the alpha-1 adrenergic receptor of sympathetic nerve. The effects of prazosin in patient with epidural lumbar anesthesia were analyzed with blind test. In a prospective randomized study, we... -
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- Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplasia
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Kim SK, Chung JH, Lee BC, Lee SW, Lee KH, Kim YO
- KMID: 2232731
- Int Neurourol J.
- 2014 Dec;18(4):179-186.
- doi: 10.5213/inj.2014.18.4.179
PURPOSE: Benign prostatic hyperplasia (BPH) is the most common prostate problem in older men. The present study aimed to investigate the inhibitory effect of Panax ginseng C.A. Meyer (P. ginseng)... -
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- Adrenergic sensitivity of uninjured C-fiber nociceptors in neuropathic rats
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Nam TS, Yeon DS, Leem JW, Paik KS
- KMID: 1758517
- Yonsei Med J.
- 2000 Apr;41(2):252-257.
- doi: 10.3349/ymj.2000.41.2.252
We investigated the adrenergic sensitivity of afferent fibers in the L4 dorsal roots of rats with a unilateral ligation of the L5-L6 spinal nerves. About 12% of nociceptive fibers on... -
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- Capsaicin-Sensitive Sensory Nerves Indirectly Modulate Motor Function of the Urinary Bladder
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Chang HH, Chang SJ, Hsieh CH, Hsu CK, Yang SS
- KMID: 2417780
- Int Neurourol J.
- 2018 Jun;22(2):83-89.
- doi: 10.5213/inj.1836078.039
PURPOSE: The urinary bladder (UB) is innervated by both sensory and autonomic nerves. Recent studies have shown that sensory neuropeptides induced contractions in the detrusor muscle. Therefore, in a mouse... -
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- Chronic stress enhances progression of periodontitis via alpha1-adrenergic signaling: a potential target for periodontal disease therapy
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Lu H, Xu M, Wang F, Liu S, Gu J, Lin S
- KMID: 2155383
- Exp Mol Med.
- 2014 Oct;46(10):e118.
- doi: 10.1038/emm.2014.65
This study assessed the roles of chronic stress (CS) in the stimulation of the sympathetic nervous system and explored the underlying mechanisms of periodontitis. Using an animal model of periodontitis... -
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- Ketanserin and Naftopidil Enhance the Potentiating Effect of Alpha-Methyl-Serotonin on the Neurally-Induced Contraction of Human Isolated Urinary Bladder Muscle Strips
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Hattori T, Lluel P, Rouget C, Rekik M, Yoshiyama
- KMID: 2375590
- Int Neurourol J.
- 2017 Mar;21(1):20-28.
- doi: 10.5213/inj.1732758.379
PURPOSE: The aim of this study was to assess the potential involvement of a specific subtype of 5-hydroxytryptamine (5-HT), 5HT(2) receptors in neurally-induced contractions of the human detrusor. METHODS: Contractile responses... -
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- Inhibitory G proteins and their receptors: emerging therapeutic targets for obesity and diabetes
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Kimple ME, Neuman JC, Linnemann , Casey PJ
- KMID: 2155367
- Exp Mol Med.
- 2014 Jun;46(6):e102.
- doi: 10.1038/emm.2014.40
The worldwide prevalence of obesity is steadily increasing, nearly doubling between 1980 and 2008. Obesity is often associated with insulin resistance, a major risk factor for type 2 diabetes mellitus... -
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- cDNA Array Analysis of Genes Expressed in the Rat Polycystic Ovary Induced by Dehydroepiandrosterone
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Jeong CH, Kim HC, Kang SG, Kim JR
- KMID: 2272403
- Korean J Obstet Gynecol.
- 2004 Oct;47(10):1931-1939.
OBJECTIVE: Polycystic Ovarian Syndrome (PCOS) is the most common endocrine disorder. Chronic anovulation, hyperandrogenism, hirsutism, obesity, infertility and polycystic ovaries (PCO) are clinical hallmarks of PCOS. PCO can be induced... -
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- Comparison of relaxation responses of cavernous and trigonal smooth muscles from rabbits by alpha1-adrenoceptor antagonists; prazosin, terazosin, doxazosin, and tamsulosin
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Seo KK, Lee MY, Lim SW, Kim SC
- KMID: 1062200
- J Korean Med Sci.
- 1999 Feb;14(1):69-74.
- doi: 10.3346/jkms.1999.14.1.69
Alpha1a-adrenergic receptor (AR) primarily mediates the contraction of the prostatic and cavernous smooth muscles. Among clinically available alpha1-AR antagonists for the medical management of benign prostatic hyperplasia (BPH), tamsulosin has... -
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- Alpha-1 Adrenergic Receptor Blockers for the Treatment of Lower Urinary Tract Symptoms in Women: A Systematic Review and Meta-Analysis
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Kim DK, Lee JY, Jung JH, Kim JH, Hah YS, Hong CH, Cho KS
- KMID: 2446747
- Int Neurourol J.
- 2019 Mar;23(1):56-68.
- doi: 10.5213/inj.1836188.094
PURPOSE: To assess the effectiveness of alpha-1 adrenergic receptor blockers (α1-blockers) in the treatment of female lower urinary tract symptoms (LUTS). METHODS: A literature search was conducted using the PubMed/MEDLINE, Embase,... -
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- Efficacy of an Alpha-Blocker for the Treatment of Nonneurogenic Voiding Dysfunction in Women: An 8-Week, Randomized, Double-Blind, Placebo-Controlled Trial
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Lee YS, Lee KS, Choo MS, Kim JC, Lee JG, Seo JT, Lee JZ, Lee JY, Oh SJ, Na YG
- KMID: 2409725
- Int Neurourol J.
- 2018 Mar;22(1):30-40.
- doi: 10.5213/inj.1834904.452
PURPOSE: To evaluate the efficacy of an alpha-1 adrenergic receptor (α1-AR) blocker for the treatment of female voiding dysfunction (FVD) through a pressure-flow study. METHODS: This was a randomized, double-blind, placebo-controlled... -
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- The diabetes-induced functional and distributional changes of the alpha 1-adrenoceptor of the abdominal aorta and distal mesenteric artery from streptozotocin-induced diabetic rats
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Lee JH, Bahk JH, Park SH, Huh J
- KMID: 2092288
- Korean J Anesthesiol.
- 2011 Apr;60(4):272-281.
- doi: 10.4097/kjae.2011.60.4.272
BACKGROUND: The aim of this study was to evaluate the effect of diabetes on the function and distribution of vascular alpha1-adrenoceptors in the abdominal aorta and distal mesenteric artery from... -
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- A new member of alpha 1-adrenoceptor-coupled G alpha h (transglutaminase II) family in pig heart: purification and characterization
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Yoo SM, Jeong HS, Han KJ, Cho SH, Lee HS, Yun HY, Kwon NS, Baek KJ
- KMID: 754992
- Exp Mol Med.
- 1998 Jun;30(2):81-86.
We previously reported an identification of a 77-kDa GTP-binding protein that co-purified with the alpha 1-adrenoceptor following ternary complex formation. In the present paper, we report on the purification and characterization of... -
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- Gender difference and change of alpha1-adrenoceptors in the distal mesenteric arteries of streptozotocin-induced diabetic rats
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Park SH, Bahk JH, Oh AY, Gil NS, Huh J, Lee JH
- KMID: 2092325
- Korean J Anesthesiol.
- 2011 Nov;61(5):419-427.
- doi: 10.4097/kjae.2011.61.5.419
BACKGROUND: The purpose of this study was to evaluate the gender-related changes in the function and distribution of alpha1-adrenoceptors in the distal mesenteric artery of streptozotocin (STZ)-induced diabetic rats at... -
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- Expression of alpha1 Receptor and Nitric Oxide Synthase in Oophorectomized and Estrogen-Supplemented Rat Bladder and Urethra
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Seo Y, Park SW, Kim JY, Lee SD
- KMID: 2069792
- Korean J Urol.
- 2014 Oct;55(10):677-686.
- doi: 10.4111/kju.2014.55.10.677
PURPOSE: To investigate the effects of estrogen on the expression of the alpha1 receptor and nitric oxide synthase (NOS) in rat urethra and bladder after oophorectomy. MATERIALS AND METHODS: Forty-five mature... -
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