- Psychiatric Implication for the Regulation of AMPA Receptor
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Oh D, Lee E
- KMID: 2299868
- Korean J Biol Psychiatry.
- 2013 Feb;20(1):1-5.
Glutamate receptors are important components of synaptic transmission in the nervous system. Especially, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors mediate most abundant excitatory synaptic transmission in the brain. There is elaborate... -
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- Electrophysiological Characterization of AMPA and NMDA Receptors in Rat Dorsal Striatum
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Jeun SH, Cho HS, Kim KJ, Li QZ, Sung KW
- KMID: 2071673
- Korean J Physiol Pharmacol.
- 2009 Jun;13(3):209-214.
- doi: 10.4196/kjpp.2009.13.3.209
The striatum receives glutamatergic afferents from the cortex and thalamus, and these synaptic transmissions are mediated by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) and N-methyl-D-aspartate (NMDA) receptors. The purpose of this study was to... -
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- The Role of AMPA Receptors in Synaptic Plasticity by Drugs of Abuse
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Kwak MJ, Kim JH
- KMID: 2287761
- Korean J Psychopharmacol.
- 2014 Oct;25(4):149-154.
- doi: 10.0000/kjp.2014.25.4.149
Dopamine has long time considered as the main player in drug addiction. However, growing body of literature strongly supports a role for glutamate in addiction. 2-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors,... -
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- A Possible Role of Kainate Receptors in C2C12 Skeletal Myogenic Cells
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Park JY, Han J, Hong SG
- KMID: 1607524
- Korean J Physiol Pharmacol.
- 2003 Dec;7(6):375-379.
Ca2+ influx appears to be important for triggering myoblast fusion. It remains, however, unclear how Ca2+ influx rises prior to myoblast fusion. Recently, several studies suggested that NMDA receptors may... -
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- The Temporospatial Distribution of Glutamate Receptors and the Effect of MK-801 on Glutamate Receptors Activation in Kainate-induced Seizure Model: Quantitative Receptor Autoradiography of Ionotropic Glutamate Receptors
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Kim MK, Kim BC, Sohn EJ, Cho KH, Lee MC
- KMID: 2342953
- J Korean Neurol Assoc.
- 2002 Mar;20(2):179-186.
BACKGROUND: Excitotoxicity and epileptogenesis have often been associated with glutamate receptor activation. Some evidence indicates that selective down regulation of AMPA receptor may be the mechanism of delayed neuronal cell... -
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- Expression of Glutamate Receptors in the Medial Vestibular Nuclei following Acute Hypotension
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Lee JH, Choi MA, Choi DO, Kim BK, Hong SM, Park BR
- KMID: 1518518
- J Korean Bal Soc.
- 2007 Jun;6(1):29-35.
Acute hypotension induced excitation of electrical activities and expression of c-Fos protein and pERK in the vestibular nuclei. In this study, to investigate the excitatory signaling pathway in the vestibular... -
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- Correlation between mEPSC Amplitude and Rise Time upon the Blockade of AMPA Receptor Desensitization at Hippocampal Synapses
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Jung SH, Choi S
- KMID: 1614994
- Korean J Physiol Pharmacol.
- 2002 Apr;6(2):81-86.
Conventional views of synaptic transmission generally overlook the possibility of "postfusional- control" the regulation of the speed or completeness of transmitter release upon vesicular fusion. However, such regulation often occurs... -
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- Inhibitory and Excitatory Postsynaptic Currents of Medial Vestibular Nucleus Neurons of Rats
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Chun SW, Choi JH, Park BR
- KMID: 2285272
- Korean J Physiol Pharmacol.
- 2003 Apr;7(2):59-64.
The medial vestibular nucleus (MVN) neurons are controlled by excitatory synaptic transmission from the vestibular afferent and commissural projections, and by inhibitory transmission from interneurons. Spontaneous synaptic currents of MVN... -
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- Chronic renal failure induces cell death in rat hippocampal CA1 via upregulation of alphaCaMKII/NR2A synaptic complex and phosphorylated GluR1-containing AMPA receptor cascades
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Kim JW, Ha GY, Jung YW
- KMID: 2028687
- Kidney Res Clin Pract.
- 2014 Sep;33(3):132-138.
- doi: 10.1016/j.krcp.2014.07.003
BACKGROUND: N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propinoic acid (AMPA) receptors bound to postsynaptic density-95 (PSD-95) and alpha isoform of calcium/calmodulin-dependent protein kinase II (alphaCaMKII) is fundamentally involved in the regulation of working... -
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- A Role of Glutamate and GABA Receptors in the Generation of Formalin-induced Impulse Firing of Spinal Dorsal Horn Neurons in the Rat
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Bae JY, Jang JH, Jeon YH, Yoon DM, Leem JW, Nam TS, Paik KS
- KMID: 2199679
- J Korean Pain Soc.
- 2003 Dec;16(2):118-132.
BACKGROUND: A peripheral subcutaneous injection of formalin produces biphasic impulse firing of the spinal nociceptive neurons. The roles of excitatory glutamatergic and inhibitory GABAergic receptors were investigated in the formalin-induced... -
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- AMPA, not NMDA, activates RhoA GTPases and subsequetly phosphorylates moesin
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Kim SJ, Jeon S, Shin EY, Kim EG, Park J, Bae CD
- KMID: 755672
- Exp Mol Med.
- 2004 Feb;36(1):98-102.
Glutamate induced rapid phosphorylation of moesin, one of ERM family proteins involved in the ligation of membrane to actin cytoskeleton, in rat hippocampal cells (JBC, 277:16576-16584, 2002). However, the identity... -
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- Mechanism of Glutamate-induced[Ca2+]i Increase in Substantia Gelatinosa Neurons of Juvenile Rats
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Jung SJ, Choi JS, Kwak J, Kim J, Kim JW, Kim SJ
- KMID: 2285271
- Korean J Physiol Pharmacol.
- 2003 Apr;7(2):53-58.
The glutamate receptors (GluRs) are key receptors for modulatory synaptic events in the central nervous system. It has been reported that glutamate increases the intracellularCa (2+) concentration ([Ca2+]i) and induces... -
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- Up-regulation of PSD-95 in the Rat Hippocampal Formation after Chronic Renal Failure
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Jung YW, Moon IS, Choi DH, Ko BH
- KMID: 1510195
- Korean J Anat.
- 2006 Aug;39(4):289-295.
The mechanism of central nervous system (CNS) dysfunction in uremia are multifactorial and only partially characterized. Studies using hippocampal formation (HF) evaluate the relationship between the uremia and memory impairment. Immunoblots with... -
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- The Effect of Intrathecal ACEA 2085, Highly Selective AMPA Receptor Antagonist on the Hyperalgesia Observed after Thermal Injury in the Rat
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Jun JH, Yeom JH, Kim YC, Shim JC, Kim KH, Suh JK, Yoo HK
- KMID: 2335845
- J Korean Pain Soc.
- 1999 May;12(1):1-7.
BACKGROUND: To study the role of spinal alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptors in pain behaviors caused by mild bum, we examined the effect of intrathecal administered ACEA 2085, which has been recently characterized... -
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- Analysis of Interaction between Intrathecal Gabapentin with MK801, 5,7-DKA or NBQX in the Rat Formalin Test
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Kim MK, Ki HG, Choi JI, Yoon MH, Jeong CY
- KMID: 2274924
- Chonnam Med J.
- 2005 Aug;41(2):200-208.
Spinal NMDA receptor and AMPA receptor are involved in the modulation of nociceptive transmission. It has been known that the antinociception of gabapentin is linked to these sites. We evaluated... -
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- Facilitation of AMPA receptor-mediated steady-state current by extrasynaptic NMDA receptors in supraoptic magnocellular neurosecretory cells
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Pai YH, Lim CS, Park KA, Cho HS, Lee GS, Shin YS, Kim HW, Jeon BH, Yoon SH, Park JB
- KMID: 2371060
- Korean J Physiol Pharmacol.
- 2016 Jul;20(4):425-432.
- doi: 10.4196/kjpp.2016.20.4.425
In addition to classical synaptic transmission, information is transmitted between cells via the activation of extrasynaptic receptors that generate persistent tonic current in the brain. While growing evidence supports the... -
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- Connecting the dots between SHP2 and glutamate receptors
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Ryu HH, Kim SY, Lee YS
- KMID: 2471034
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):129-135.
- doi: 10.4196/kjpp.2020.24.2.129
SHP2 is an unusual protein phosphatase that functions as an activator for several signaling pathways, including the RAS pathway, while most other phosphatases suppress their downstream signaling cascades. The physiological... -
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- AMPA Receptor-Induced Neuronal Cell Death in Rat Hippocampus Following Transient Global Ischemia: Relationship to Calpain and Caspase-3 Expression
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Jung Y, Hong S, Ko B
- KMID: 1894520
- Korean J Anat.
- 2003 Feb;36(1):77-88.
A central challenge in ischemia-induced neuronal death research is understanding the mechanisms by which apoptotic or necrotic cascades are initiated and affected. We tested potential roles for AMPA and NMDA receptor... -
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- Roles of metabotropic glutamate receptors on excitatory synaptic transmission in rat trigeminal caudal neurons
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Choi JH, Chae SC, Min SK, Chun SW
- KMID: 1515870
- J Korean Assoc Maxillofac Plast Reconstr Surg.
- 2004 Sep;26(5):461-468.
The caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn : MDH) is implicated in the processing of nociceptive information in the orofacial region. Whole cell patch clamp recordings... -
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- Experimental Study of Initiation of Cortical Spreading Depression by Excitatory Amino Acids Using a New Topical Application Model
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Park JY, Park YK, Chung YG, Chung HS, Lee KC, Lee HK
- KMID: 2010223
- J Korean Neurosurg Soc.
- 1996 Mar;25(3):462-472.
The purpose of this study was, first, to devise a new model for topical application of excitatory amino acids(EAAs) to rat cerebral cortex that successfully and repeatdly initiate the cortical... -
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