J Korean Bal Soc.  2007 Jun;6(1):29-35.

Expression of Glutamate Receptors in the Medial Vestibular Nuclei following Acute Hypotension

• Lee JH
• Choi MA
• Choi DO
• Kim BK
• Hong SM
• Park BR

Abstract

Acute hypotension induced excitation of electrical activities and expression of c-Fos protein and pERK in the vestibular nuclei. In this study, to investigate the excitatory signaling pathway in the vestibular nuclei following acute hypotension, expression of NR2A and NR2B subunits of glutamate NMDA receptor and GluR1 subunit of glutamate AMPA receptor was determined by RT-PCR and Western blotting in the medial vestibular nucleus 30 min after acute hypotension in rats. Acute hypotension increased expression of NR2A, NR2B, and pGluR1 in the medial vestibular nuclei. These results suggest that both of NMDA and AMPA glutamate receptors take part in transmission of excitatory afferent signals following acute hypotension.

Keyword

Vestibular nuclei; Acute hypotension; Glutamate receptor

MeSH Terms

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
Animals
Blotting, Western
Glutamic Acid*
Hypotension*
N-Methylaspartate
Rats
Receptors, AMPA
Receptors, Glutamate*
Vestibular Nuclei*
Glutamic Acid
N-Methylaspartate
Receptors, AMPA
Receptors, Glutamate
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid