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LRIG1 Enhances Chemosensitivity by Modulating BCL-2 Expression and Receptor Tyrosine Kinase Signaling in Glioma Cells

Guo Z, Chen Q, Liu B, Tian D, Zhang S, Li M

PURPOSE: Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) are an inhibitor of receptor tyrosine kinases (RTKs) that was discovered in recent years, and many studies showed that LRIG1 is a...
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Expression of Down Stream Molecules of RET (p-ERK, p-p38 MAPK, p-JNK and p-AKT) in Papillary Thyroid Carcinomas

Shin E, Hong SW, Kim SH, Yang WI

  • KMID: 2428328
  • Yonsei Med J.
  • 2004 Apr;45(2):306-313.
To evaluate the roles of 4 putative downstream molecules (ERK, p38 MAPK, JNK and AKT) of the RET signal pathway in the tumorigenesis of papillary carcinomas, the expression patterns of...
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Clinicopathologic and Molecular Characteristics of Lung Adenocarcinoma Arising in Young Patients

Kim L, Kim KH, Yoon YH, Ryu JS, Choi SJ, Park IS, Han JY, Kim JM, Chu YC

Lung cancer rarely occurs in young patients. Recent studies have demonstrated that epidemiologic data are closely correlated to some molecular characteristics. We investigated the clinicopathologic characteristics of lung adenocarcinoma in...
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Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro

Park HY, Kwon HM, Lim HJ, Hong BK, Lee JY, Park BE, Jang YS, Cho SY, Kim HS

  • KMID: 1085746
  • Exp Mol Med.
  • 2001 Jun;33(2):95-102.
Leptin, the product of ob gene, is an endocrine hormone that regulates adipose tissue mass. Recently, leptin has been found to generate a growth signal involving a tyrosine kinase-dependent intracellular...
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