- The Effect of Leptin Level Fluctuations by a Repeated Fasting/Refeeding on the Leptin Sensitivity in OLETF Rats
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Kim MS
- KMID: 1479221
- J Korean Endocr Soc.
- 2008 Oct;23(5):298-301.
- doi: 10.3803/jkes.2008.23.5.298
No abstract available. -
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- Ultrastructural Changes in Corneas of Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
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Park HJ, Lee JS
- KMID: 2126045
- J Korean Ophthalmol Soc.
- 2004 May;45(5):825-831.
PURPOSE: To evaluate the changes in corneal fine structure of diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats, compared with age-matched nondiabetic rats. METHODS: At the ages of 30 and 50... -
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- Effect of 17-beta Estradiol on Adipocyte Lipin-1 Expression in OLETF Rat
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Lee SK
- KMID: 2169053
- Endocrinol Metab.
- 2010 Sep;25(3):177-179.
- doi: 10.3803/EnM.2010.25.3.177
No abstract available. -
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- The Effect of Leptin Level Fluctuations by a Repeated Fasting/Refeeding on the Leptin Sensitivity in OLETF Rats
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Park SC, Park YH, Park SY, Kim JY, Park YK, Lee TH, Won KC, Kim YW
- KMID: 1479223
- J Korean Endocr Soc.
- 2008 Oct;23(5):310-318.
- doi: 10.3803/jkes.2008.23.5.310
BACKGROUND: Leptin resistance is a common feature in obese subjects and animals, and this is commonly accompanied with hyperleptinemia. We speculated that one of the causes of leptin resistance is... -
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- Effects of Rosiglitazone on Inflammation in Otsuka Long-Evans Tokushima Fatty Rats
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Lee JW, Nam-Goong , Kim JG, Yun CH, Kim SJ, Choi JI, Kim YI, Kim ES
- KMID: 2222375
- Korean Diabetes J.
- 2010 Jun;34(3):191-199.
- doi: 10.4093/kdj.2010.34.3.191
BACKGROUND: Inflammation plays a role in the response to metabolic stress in type 2 diabetes. However, the effects of rosiglitazone on inflammation of skeletal muscle have not been fully examined... -
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- Ultrastructural Investigation of the Retinal Changes in Diabetic Rat (OLETF)
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Park JM, Lee JE, Oum BS
- KMID: 2337792
- J Korean Ophthalmol Soc.
- 2010 Jan;51(1):112-119.
PURPOSE: To compare retinal ultra-structures of diabetic rats (OLETF, Otsuka Long-Evans Tokushima Fatty) with those of agematched non-diabetic rats (LETO, Long-Evans Tokushima Otsuka) using transmission electron micrography (TEM). METHODS: The body... -
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- Anti-diabetic effects of benfotiamine on an animal model of type 2 diabetes mellitus
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Chung KM, Kang W, Kim DG, Hong HJ, Lee Y, Han CH
- KMID: 1700786
- Korean J Vet Res.
- 2014 Mar;54(1):21-26.
Although benfotiamine has various beneficial anti-diabetic effects, the detailed mechanisms underlying the impact of this compound on the insulin signaling pathway are still unclear. In the present study, we evaluated... -
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- Effect of Heat Shock on the Vascular Reactivity and Expression of Heat Shock Protein in an Animal Model of Type 2 Diabetes Mellitus (OLETF rat)
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Lee SH, Ha SW, Kim BW
- KMID: 1767998
- J Korean Diabetes Assoc.
- 2003 Jun;27(3):199-212.
BACKGROUND: Heat shock proteins (HSPs) are highly expressed in cardiovascular tissues, with heat shock possibly modulating the vascular reactivity to vasoactive agents. An abnormal vascular reactivity has been shown in... -
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- The Effects of Alpha-Lipoic Acid on Epidermal Nerve Preservation in the Diabetic Neuropathy of OLETF Rats
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Piao MH, Park JH, Baek HS, Park TS
- KMID: 2177609
- J Korean Diabetes Assoc.
- 2006 May;30(3):170-176.
- doi: 10.4093/jkda.2006.30.3.170
BACKGROUND: Alpha-Lipoic acid (ALA) administration has been reported to ameliorate some of symptoms of peripheral polyneuropathy in diabetic patients and to improve endoneurial nutritive neural blood flow and nerve conduction... -
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- Effects of Cilostazol on Insulin Resistance in OLETF Rats
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Kim SR, Baek KH, Ko SH, Lee JM, Chang SA, Ahn YB, Yoo SJ, Lee JM, Son HS, Yoon KH, Kang MI, Cha BY, Lee KW, Son HY, Kang SK
- KMID: 2010070
- J Korean Diabetes Assoc.
- 2001 Feb;25(1):63-70.
BACKGROUND: Insulin resistance is one of the major pathophysiology of type 2 diabetes mellitus. It is reported that cilostazol and cyclic AMP phosphodiesterase inhibitor has the anti-platelet effect as well... -
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- Effects of Caloric Restriction on the Expression of PGC-1 and PPARs mRNA in Liver of Otsuka Long-Evans Tokushima Fatty Rats
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Kim SY, Kim JH, Bae HY, Lee BR
- KMID: 2177607
- J Korean Diabetes Assoc.
- 2006 May;30(3):161-169.
- doi: 10.4093/jkda.2006.30.3.161
BACKGROUND: Gluconeogenesis is strongly stimulated during fasting and is aberrantly activated in diabetes mellitus. PPARgamma-coactivator 1 (PGC-1) and Peroxisome proliferator -activated receptors (PPARs) costimulate the expression of key enzymes of... -
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- Differential Expression of Metabolism-related Genes in Liver of Diabetic Obese Rats
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Seo E, Park EJ, Park MK, Kim DK, Lee HJ, Hong SH
- KMID: 1457675
- Korean J Physiol Pharmacol.
- 2010 Apr;14(2):99-103.
- doi: 10.4196/kjpp.2010.14.2.99
The Otsuka Long-Evans Tokushima Fatty (OLETF) rat, a model of spontaneous type 2 diabetes (T2D), develops hyperglycemic obesity with hyperinsulinemia and insulin resistance after the age of 25 weeks, similar... -
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- Erectile Function and Cavernosal TGF-beta Expression in the OLETF Rats
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Park SH, Kim M, Min K, Park K
- KMID: 2226688
- Korean J Androl.
- 2002 Aug;20(2):82-86.
PURPOSE: The mechanism of erectile dysfunction in type II non-insulin dependent diabetes mellitus (NIDDM) has not been well demonstrated. The aims of this study were to investigate erectile function and... -
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- Taurine-Mediated Restoration of Glucose Sensitivity of Pancreatic Beta Cells in OLETF Rats
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Kim SY, Park KG, Lee IK, Nam SI, Song DK
- KMID: 2177775
- J Korean Diabetes Assoc.
- 2005 May;29(3):198-205.
BACKGROUND: An OLETF(Otsuka Long-Evans Tokushima Fatty) rat is a model of type 2 diabetes that is characterized by obesity-induced insulin resistance. Taurine has been known to be beneficial for type... -
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- Naloxone Increases the Anorexic Effect of MTII in OLETF Rats
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Bae JH, Park YH, Kim SH, Park SY, Kim JY, Son JY, Huh JY, Won KC, Kim YW
- KMID: 2063546
- J Korean Endocr Soc.
- 2008 Feb;23(1):18-26.
- doi: 10.3803/jkes.2008.23.1.18
BACKGROUND: Leptin, an adipocyte-derived hormone, inhibits obesity in lean subjects, but is not widely used because of leptin resistance. Thus, circumventing the arcuate nucleus of the hypothalamus, the site responsible... -
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- Angiotensin-Converting Enzyme Inhibitor Ramipril Improves Coronary Microvascular Remodeling in Type II Diabetic Rats
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Chang K, Baek SH, Ko SH, Yoon KH, Kim KY, Seung KB, Chae JS, Kim JH, Hong SJ, Choi KB
- KMID: 1858695
- Korean Circ J.
- 2002 Aug;32(8):680-688.
- doi: 10.4070/kcj.2002.32.8.680
BACKGROUND AND OBJECTIVES: Coronary microvascular remodeling is one of the complications associated with diabetic cardiovascular disease. We investigated the effect of long-term treatment with ramipril, an angiotensin converting enzyme inhibitor,... -
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- Thiazolidinediones on Insulin Resistance and Insulin Secretion in Obese Diabetic OLETF Rats
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Noh JH, Hong SH, Lee KH, Min KM, Yang TY, Lee MS, Kim KW, Lee MK
- KMID: 2008094
- J Korean Diabetes Assoc.
- 2007 Jan;31(1):33-43.
- doi: 10.4093/jkda.2007.31.1.33
BACKGROUND: Thiazolidinediones are synthetic peroxisome proliferator-activated receptor-gamma agonists that decrease insulin resistance but, as in vitro and in vivo studies suggest, may have direct beneficial effects on pancreatic beta cells.... -
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- Effect of Glycosaminoglycan on Proteinuria and Urinary N-acetyl- -D-Glucosaminidase Excretion in Otsuka Long-Evans Tokushima Fatty (OLETF) Rats
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Choi KM, Cha DR, Han SY, Kim DR, Kim NH, Baik SH, Choi DS
- KMID: 2331729
- J Korean Diabetes Assoc.
- 2000 Oct;24(5):533-540.
BACKGROUND: Increased loss of proteoglycan (PG) characterized by an increased loss of anionic charges in the basement membrane has been considered as one of main factors causing urinary loss of... -
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- Penile Expression of Hypoxia-inducible Factor-1alpha, Vascular Endothelial Growth Factor, and Nitric Oxide Synthase in the Type II Diabetic Rat
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Park HJ, Park BK, Park NC
- KMID: 2226644
- Korean J Androl.
- 2005 Dec;23(3):144-152.
PURPOSE: Erectile dysfunction(ED) is commonly experienced in men with diabetes mellitus. Hypoxia in the penile tissue by vascular complications is regarded as a pathophysiologic factor in diabetic ED. The aim... -
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- Protective Effects of Lithospermate B on Diabetic Nephropathy in OLETF Rat
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Lee HJ, Lee GT, Kang ES, Hur KY, Zhao ZS, Ahn CW, Ha HJ, Jung MK, Cha BS, Lee HC
- KMID: 2177760
- J Korean Diabetes Assoc.
- 2005 Jul;29(4):322-332.
BACKGROUND: Magnesium lithospermate B(LAB), an active component isolated from Salvia milltiorrhizae, has been reported to have renoprotective effects in type 1 diabetic animal model. The purpose of this study was... -
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