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Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases

Lee EJ, Park JH

Receptor for advanced glycation endproducts (RAGE) is a multi-ligand receptor that is able to bind several different ligands, including advanced glycation endproducts, high-mobility group protein (B)1 (HMGB1), S-100 calcium-binding protein,...
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Up-Regulation of the Receptor for Advanced Glycation End Products in the Skin Biopsy Specimens of Patients with Severe Diabetic Neuropathy

Park SY, Kim YA, Hong YH, Moon MK, Koo BK, Kim TW

BACKGROUND AND PURPOSE: The receptor for advanced glycation end products (RAGE) may contribute to the development of diabetic neuropathy. To assess its relevance in humans, this study examined the expression...
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Up-Regulation of MiR-1915 Inhibits Proliferation, Invasion, and Migration of Helicobacter pylori-Infected Gastric Cancer Cells via Targeting RAGE

Xu XC, Zhang WB, Li CX, Gao H, Pei Q, Cao BW, He TH

PURPOSE: Helicobacter pylori (HP)-infected gastric cancer (GC) is known to be a fatal malignant tumor, but the molecular mechanisms underlying its proliferation, invasion, and migration remain far from being completely...
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Ameliorative Effects of Nilotinib on CCl4 Induced Liver Fibrosis Via Attenuation of RAGE/HMGB1 Gene Expression and Oxidative Stress in Rat

Khanjarsim V, Karimi J, Khodadadi , Mohammadalipour A, Goodarzi M, Solgi G, Hashemnia

Nilotinib as a tyrosine kinase inhibitor has been recently used to improve the liver fibrosis process, but the exact mechanisms still require further clarification. In this study, we investigated the...
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PPAR-gamma Agonist Attenuates Myocardial Fibrosis in a Type 2 Diabetic Rat Model

Ihm SH, Chang KY, Kim PJ, Kim HY, Baek SH, Youn HJ, Seung KB, Kim JH, Hong SJ, Choi KB

BACKGROUND AND OBJECTIVES: Receptor for advanced glycosylation end product (RAGE) plays an important role in the development of myocardial fibrosis in diabetics. Activation of peroxisome proliferator activated receptor (PPAR)-gamma agonist,...
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Object Relations Theories on Narcissistic Personality Disorder

Ku JI, Yu BH

  • KMID: 2051189
  • Psychoanalysis.
  • 2010 Apr;21(1):27-31.
Patients with narcissistic personality disorders have difficulties in developing emotional relationships with their analysts due to narcissistic withdrawal. The patients devalue and depreciate their analysts as an independent object in...
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Effects of Angiotensin-Converting Enzyme Polymorphism on Soluble Receptor for Advanced Glycation End-Products in Maintenance Hemodialysis Patients

Lee KW, Cha JM, Lee YM, Park SD, Song JH, Ahn SH

  • KMID: 2267772
  • Korean J Med.
  • 2013 Nov;85(5):495-502.
BACKGROUND/AIMS: Advanced glycation end-products (AGEs) exert various toxic effects through the receptor for AGEs (RAGE). Soluble RAGE (sRAGE) is a naturally occurring inhibitor of AGE-RAGE. Recent studies have suggested that...
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A Case of Hypersomnolence with Subclinical Hypothyroidism Treated with Levothyroxine

Kim M, Chae SH, Oh EH, Kim BK, Kim DJ, Cho JW

We present a patient who complained of excessive daytime sleepiness (EDS), which started three years ago. She had no other medical, neurological, and psychiatric disorders. Nocturnal polysomnography did not indicate...
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The Effects of Macrophage on Neointimal Formation after Balloon or Stent Injury in Hypercholesterolemic Rabbits

Rhee MY, Kim YK, Lee MY, Park BE, Kim DW, Cho MC

BACKGROUND AND OBJECTIVES: The present study investigated differences in the effects of macrophages between neointimal formation after balloon (BI) and that after stent injury (SI) in hypercholesterolemic rabbits. We also...
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Paradoxical Reaction to Midazolam Used in Intravenous Sedation for Dental Treatment: Report of a Case and Review of the Literature

Jeon JY, Jung SH, Lee BH, Im JJ, Hwang KG, Shim KS, Park CJ

Midazolam, one of the most common benzodiazepine derivatives, is widely used in intravenous sedation for dental treatment without severe complications. However, paradoxical reactions to midazolam, including patient's unanticipated restlessness, agitation,...
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N epsilon(Carboxymethyl)Lysine-Induced Mesangial Cell Activation

Lim HJ, Song JS, Ha HJ, Lee HB

  • KMID: 2254451
  • Korean J Nephrol.
  • 2002 Jan;21(1):20-28.
BACKGROUND: Advanced glycation end products (AGE) are independent risk factors in the development and progression of diabetic nephropathy. Receptor for AGE(RAGE) is considered the main receptor involved in AGE-induced cell...
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The Perception of Teenagers on the Bully: With the subject of primary, middle and high school students

Chung HK, Kim KH

  • KMID: 2375011
  • J Korean Acad Nurs.
  • 2000 Feb;30(1):137-147.
The purpose of this study was to investigate characteristics of teenagers' perceptions to bullies according to the classification types of Q-methodology. The results of the analysis were classified in 5...
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Heat Shock Protein as Molecular Targets for Breast Cancer Therapeutics

Kim LS, Kim JH

  • KMID: 2394768
  • J Breast Cancer.
  • 2011 Sep;14(3):167-174.
Recent advances in the understanding of the molecular mechanisms involved in the breast cancer development and progression have led to the identification of numerous novel molecular targets. Among these, heat...
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Radiologic findings of double contrast knee arthrography

Choi HR, Ahn BY, Kim MY, Lee SH, Suh CH, Chung WK

Double contrast arthrography of the knee is a highly accurate diagnositc modality in wide rage of the clinical disorders of the knee. It allows radiological assessment of the menisci, the...
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Clinical Significance of Tumor Markers in A Patient with Recurrent CNS Non-Germinomatous Germ Cell Tumor

Chang DI, Yoon SS, Chung KC

  • KMID: 2342409
  • J Korean Neurol Assoc.
  • 1994 Jun;12(2):329-337.
Quantitative serial measurements of Alpha-fetoprotein (a-FP) and Beta-human chorionic gonadotropin (B-HCG) using radioimmunoassay were performed in a patient with recurrent non-germinomatous germ cell tumor (NGGCT) into CNS during radiotherapy and...
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CRISPR/Cas9 Edited sRAGE-MSCs Protect Neuronal Death in Parkinson's Disease Model

Lee J, Bayarsaikhan D, Arivazhagan R, Park H, Lim B, Gwak P, Jeong GB, Lee J, Byun K, Lee B

BACKGROUND AND OBJECTIVES: Parkinson’s disease (PD) is a fatal and progressive degenerative disease of the nervous system. Until recently, its promising treatment and underlying mechanisms for neuronal death are poorly...
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Study on Range of Head and Cervical Motions in Young Korean Adults

Kim HJ, Kim HT

  • KMID: 2283419
  • Korean J Phys Anthropol.
  • 2008 Jun;21(2):113-121.
It is not easy and simple to evaluate of the range of motion (ROM) of the head and neck, although it is important clinically. This study was performed to evaluated...
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The characteristics of medical students' personality types and interpersonal needs

Hur Y, Cho AR, Kim S

  • KMID: 1986159
  • Korean J Med Educ.
  • 2013 Dec;25(4):309-316.
PURPOSE: Medical students' personality types and interpersonal needs must be considered. The purpose of this study was to examine the characteristics of personality types and interpersonal needs. METHODS: A total of...
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A case of amebiasis in the newborn period

Park JY, Bae SY, Kim DH, Choi CH, Cho EY, Choi JH, Kim SM

Entamoeba histolytica (E. histolytica) is a worldwide protozoan parasite causing a wide rage of intestinal disease in human, including asymptomatic cyst carriage, acute diarrhea, fulminant dysentery, and chronic nondysenteric colitis....
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High Dose Ramipril Inhibits Connective Tissue Growth Factor Expression and Fibrosis in Type 2 Diabetic Rat Heart

Choi KH, Baek SH, Lee WJ, Park KN, Kim PJ, Seung KB, Chae JS, Kim JH, Choi KB

BACKGROUND AND OBJECTIVES: Connective tissue growth factor (CTGF) is a profibrotic cytokine, which may play an important role in the development of diabetic cardiovascular complications. ACE inhibition significantly prevents cardiovascular...
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