- The Role of Pyruvate Dehydrogenase Kinase in Diabetes and Obesity
-
Lee IK
- KMID: 2280687
- Diabetes Metab J.
- 2014 Jun;38(3):181-186.
- doi: 10.4093/dmj.2014.38.3.181
The pyruvate dehydrogenase complex (PDC) is an emerging target for the treatment of metabolic syndrome. To maintain a steady-state concentration of adenosine triphosphate during the feed-fast cycle, cells require efficient... -
- CITED
-
- Close
- SHARE
-
- Close
- Anesthetic experience in a pediatric patient with pyruvate dehydrogenase complex (PDHC) deficiency: A case report
-
Ro J, Kim EJ, Lee JH, Lee SG, Ban JS, Min BW
- KMID: 2243008
- Korean J Anesthesiol.
- 2008 Nov;55(5):629-633.
- doi: 10.4097/kjae.2008.55.5.629
Mitochondrial dysfunction represents a biochemically and clinically diverse group of conditions that can affect any organs with high energy requirement such as brain and muscle being particularly vulnerable. Pyruvate dehydrogenase... -
- CITED
-
- Close
- SHARE
-
- Close
- Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers
-
Jeoung NH
- KMID: 2281531
- Diabetes Metab J.
- 2015 Jun;39(3):188-197.
- doi: 10.4093/dmj.2015.39.3.188
Impaired glucose homeostasis is one of the risk factors for causing metabolic diseases including obesity, type 2 diabetes, and cancers. In glucose metabolism, pyruvate dehydrogenase complex (PDC) mediates a major... -
- CITED
-
- Close
- SHARE
-
- Close
- Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases
-
Patel MS, Korotchkina LG
- KMID: 1457529
- Exp Mol Med.
- 2001 Dec;33(4):191-197.
This review summarizes the recent developments on the regulation of human pyruvate dehydrogenase complex (PDC) by site-specific phosphorylation by four kinases. Mutagenic analysis of the three phosphorylation sites of human... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels
-
Jeoung NH, Harris RA
- KMID: 2029884
- Korean Diabetes J.
- 2010 Oct;34(5):274-283.
- doi: 10.4093/kdj.2010.34.5.274
In the well-fed state a relatively high activity of the pyruvate dehydrogenase complex (PDC) reduces blood glucose levels by directing the carbon of pyruvate into the citric acid cycle. In... -
- CITED
-
- Close
- SHARE
-
- Close
- Role of the Pyruvate Dehydrogenase Complex in Metabolic Remodeling: Differential Pyruvate Dehydrogenase Complex Functions in Metabolism
-
Park S, Jeon JH, Min BK, Ha CM, Thoudam T, Park BY, Lee IK
- KMID: 2418715
- Diabetes Metab J.
- 2018 Aug;42(4):270-281.
- doi: 10.4093/dmj.2018.0101
Mitochondrial dysfunction is a hallmark of metabolic diseases such as obesity, type 2 diabetes mellitus, neurodegenerative diseases, and cancers. Dysfunction occurs in part because of altered regulation of the mitochondrial... -
- CITED
-
- Close
- SHARE
-
- Close
- Inhibition of Sarcoplasmic Reticulum Ca2+ Uptake by Pyruvate and Fatty Acid in H9c2 Cardiomyocytes: Implications for Diabetic Cardiomyopathy
-
Lee EH, Lee HK, Kim HW, Kim YH
- KMID: 1600069
- Korean J Physiol Pharmacol.
- 2005 Aug;9(4):195-201.
High extracellular glucose concentration was reported to suppress intracellular Ca2+ clearing through altered sarcoplasmic reticulum (SR) function. In the present study, we attempted to elucidate the effects of pyruvate and... -
- CITED
-
- Close
- SHARE
-
- Close
- A Korean Female Patient with Thiamine-responsive Pyruvate Dehydrogenase Complex Deficiency Due to a Novel Point Mutation (Y161C)in the PDHA1 Gene
-
Lee EH, Ahn MS, Hwang JS, Ryu KH, Kim SJ, Kim SH
- KMID: 1781895
- J Korean Med Sci.
- 2006 Oct;21(5):800-804.
- doi: 10.3346/jkms.2006.21.5.800
Pyruvate dehydrogenase complex (PDHC) deficiency is mostly due to mutations in the X-linked E1alpha subunit gene (PDHA1). Some of the patients with PDHC deficiency showed clinical improvements with thiamine treatment.... -
- CITED
-
- Close
- SHARE
-
- Close
- Transcriptional Regulation of Pyruvate Dehydrogenase Kinase
-
Jeong JY, Jeoung NH, Park KG, Lee IK
- KMID: 2174390
- Diabetes Metab J.
- 2012 Oct;36(5):328-335.
- doi: 10.4093/dmj.2012.36.5.328
The pyruvate dehydrogenase complex (PDC) activity is crucial to maintains blood glucose and ATP levels, which largely depends on the phosphorylation status by pyruvate dehydrogenase kinase (PDK) isoenzymes. Although it... -
- CITED
-
- Close
- SHARE
-
- Close
- Regulation of Muscle Pyruvate Dehydrogenase Complex in Insulin Resistance: Effects of Exercise and Dichloroacetate
-
Constantin-Teodosiu D
- KMID: 1965976
- Diabetes Metab J.
- 2013 Oct;37(5):301-314.
- doi: 10.4093/dmj.2013.37.5.301
Since the mitochondrial pyruvate dehydrogenase complex (PDC) controls the rate of carbohydrate oxidation, impairment of PDC activity mediated by high-fat intake has been advocated as a causative factor for the... -
- CITED
-
- Close
- SHARE
-
- Close
- Inherited metabolic diseases in the urine organic acid analysis of complex febrile seizure patients
-
Cheong HJ, Kim HR, Lee SS, Bae EJ, Park WI, Lee HJ, Choi HC
- KMID: 2281676
- Korean J Pediatr.
- 2009 Feb;52(2):199-204.
- doi: 10.3345/kjp.2009.52.2.199
PURPOSE: Seizure associated with fever may indicate the presence of underlying inherited metabolic diseases. The present study was performed to investigate the presence of underlying metabolic diseases in patients with... -
- CITED
-
- Close
- SHARE
-
- Close
- Organic Acidemias in Korea: Three Years Experience of Organic Acid Analysis
-
Choi YK, Kim ES, Bae EJ, Park WI, Lee KJ, Lee HJ
- KMID: 2335686
- J Korean Pediatr Soc.
- 2002 Nov;45(11):1346-1358.
PURPOSE: We have done this retrospective study to know the relative incidences and clinical manifestations of organic acidopathies in Korea. METHODS: The results of quantitative organic acid analysis of 1,125... -
- CITED
-
- Close
- SHARE
-
- Close
- Organic acidemias in Korea: Eight years experience of organic acid analysis
-
Bang JS, Lim SH, Lee KH, Bae EJ, Park WI, Lee HJ
- KMID: 2278583
- Korean J Pediatr.
- 2006 Mar;49(3):258-267.
- doi: 10.3345/kjp.2006.49.3.258
PURPOSE: We have done this retrospective study to know the relative incidence and clinical manifestations of organic acidopathies in Korea during 8 years(from Jul. 1997 to May 2005). This results... -
- CITED
-
- Close
- SHARE
-
- Close
- FDG-PET for Evaluating the Antitumor Effect of Intraarterial 3-Bromopyruvate Administration in a Rabbit VX2 Liver Tumor Model
-
Park HS, Chung JW, Jae HJ, Kim YI, Son KR, Lee MJ, Park JH, Kang WJ, Yoon JH, Chung H, Lee K
- KMID: 1779437
- Korean J Radiol.
- 2007 Jun;8(3):216-224.
- doi: 10.3348/kjr.2007.8.3.216
OBJECTIVE: We wanted to investigate the feasibility of using FDG-PET for evaluating the antitumor effect of intraarterial administration of a hexokinase II inhibitor, 3-bromopyruvate (3-BrPA), in a rabbit VX2 liver... -
- CITED
-
- Close
- SHARE
-
- Close
