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Biological Network Evolution Hypothesis Applied to Protein Structural Interactome

Bolser DM, Park JH

  • KMID: 1973990
  • Genomics Inform.
  • 2003 Sep;1(1):7-19.
The latest measure of the relative evolutionary age of protein structure families was applied (based on taxonomic diversity) using the protein structural interactome map (PSIMAP). It confirms that, in general,...
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The homotrimeric structure of HtrA2 is indispensable for executing its serine protease activity

Nam MK, Seong YM, Park HJ, Choi JY, Kang S, Rhim H

  • KMID: 1105275
  • Exp Mol Med.
  • 2006 Feb;38(1):36-43.
Serine protease activity of high temperature requrement 2 (HtrA2) is essential for promoting cell death, as well as for protecting against cellular stresses. An X-ray crystallographic study described the formation...
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The centrosomal localization of KM-HN-1 (MGC33607) depends on the leucine zipper motif and the C-terminal coiled-coil domain

Park HJ, Seo HJ, Kim HW, Kim JS, Hwang SY, Seong YS

  • KMID: 1091078
  • Exp Mol Med.
  • 2007 Dec;39(6):828-838.
KM-HN-1 is a C-terminal coiled-coil domain containing protein previously referred to as image clone MGC33607. This protein has been previously identified as a cancer/testis antigen and reported as nuclear and...
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T Cell-specific Immunosuppression Using Tautomycetin or PTD-conjugated Protein Drugs

Chae WJ, Choi JM, Yang JJ, Lee SK

No abstract available.
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Membrane topology and function of the secretory Na+-K+-2Cl- cotransporter (NKCC1)

Gerelsaikhan T, Turner RJ

No abstract available.
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Identification of Viral Taxon-Specific Genes (VTSG): Application to Caliciviridae

Kang S, Kim YC

Virus taxonomy was initially determined by clinical experiments based on phenotype. However, with the development of sequence analysis methods, genotype-based classification was also applied. With the development of genome sequence...
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Structure and Function of a Minimal Receptor Activation Domain of Parathyroid Hormone

Lee EJ, Kim HY, Cho MK, Lee W, Lim SK

The structure and function of short-length amino terminal PTH analogues were studied. The substitution of Leu7 with Phe in [Ala3, 10Leu7Arg11]rPTH (1-11) NH2 analogue peptides did not show any reduction...
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Structure-activity relationships of anti-HIV-1 peptides with disulfide linkage between D- and L-cysteine at positions i and i+3, respectively, derived from HIV-1 gp41 C-peptide

Lee MK, Kim HK, Lee TY, Hahm KS, Kim KL

  • KMID: 1105273
  • Exp Mol Med.
  • 2006 Feb;38(1):18-26.
The constrained alpha-helical structure of a C-peptide is useful for enhancing anti-HIV-1 activity. The i and i+3 positions in an alpha-helical structure are located close together, therefore D-Cys (dC) and...
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A model for the reaction mechanism of the transglutaminase 3 enzyme

Ahvazi B, Steinert P

  • KMID: 1109310
  • Exp Mol Med.
  • 2003 Aug;35(4):228-242.
Transglutaminase enzymes (TGases) catalyze the calcium dependent formation of an isopeptide bond between protein-bound glutamine and lysine substrates. Previously we have shown that activated TGase 3 acquires two additional calcium...
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Atg3-Mediated Lipidation of Atg8 Is Involved in Encystation of Acanthamoeba

Moon EK, Chung DI, Hong Y, Kong HH

Autophagy is a catabolic process involved in the degradation of a cell's own components for cell growth, development, homeostasis, and the recycling of cellular products. Autophagosome is an essential component...
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Identification of determinants that mediate binding between Tembusu virus and the cellular receptor heat shock protein A9

Zhao D, Liu Q, Huang X, Wang H, Han K, Yang J, Bi K, Liu Y, Zhang L, Li Y

Heat shock protein A9 (HSPA9), a member of the heat shock protein family, is a putative receptor for Tembusu virus (TMUV). By using Western blot and co-immunoprecipitation assays, E protein...
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WNKs: protein kinases with a unique kinase domain

Huang CL, Cha SK, Wang HR, Xie J, Cobb MH

  • KMID: 1090959
  • Exp Mol Med.
  • 2007 Oct;39(5):565-573.
WNKs (with-no-lysine [K]) are a family of serine-threonine protein kinases with an atypical placement of the catalytic lysine relative to all other protein kinases. The roles of WNK kinases in...
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Systematic Classification of Mixed-Lineage Leukemia Fusion Partners Predicts Additional Cancer Pathways

Marschalek R

Chromosomal translocations of the human mixed-lineage leukemia (MLL) gene have been analyzed for more than 20 yr at the molecular level. So far, we have collected about 80 direct MLL...
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Cell-free expression and functional reconstitution of CALM in clathrin assembly

Kim JA, Kim HL

  • KMID: 1085745
  • Exp Mol Med.
  • 2001 Jun;33(2):89-94.
Clathrin-mediated vesicle formation is an essential step in the intracellular trafficking of the protein and lipid. Binding of clathrin assembly protein to clathrin triskelia induces their assembly into clathrin-coated vesicles...
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Structural basis for inhibition of protein tyrosine phosphatases by Keggin compounds phosphomolybdate and phosphotungstate.

Heo YS, Ryu JM, Park SM, Park JH, Lee HC, Hwang KY, Kim JS

  • KMID: 1380229
  • Exp Mol Med.
  • 2002 Jul;34(3):211-223.
Protein-tyrosine phosphatases (PTPs) constitute a family of receptor-like, and cytoplasmic enzymes, which catalyze the dephosphorylation of phosphotyrosine residues in a variety of receptors and signaling molecules. Together with protein tyrosine...
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The N-terminal 1-16 peptide derived in vivo from protein seminal vesicle protein IV modulates alpha-thrombin activity: potential clinical implications

Lepretti M, Costantini S, Ammirato G, Giuberti G, Caraglia M, Facchiano , Metafora S, Stiuso P

We have previously shown that seminal vesicle protein IV (SV-IV) and its 1-70 N-terminal fragment have anti-inflammatory activity and modulate anti-thrombin III (AT) activity. Moreover, mass spectrometry analysis of purified...
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In silico analysis of an envelope domain III-based multivalent fusion protein as a potential dengue vaccine candidate

Fahimi H, Sadeghizadeh M, Mohammadipour M

PURPOSE: Dengue virus infection is now a global problem. Currently, there is no licensed vaccine or proven antiviral treatment against this virus. All four serotypes (1-4) of dengue virus can...
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PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity

Lee SJ, Lee JR, Hah HS, Kim YH, Ahn JH, Bae CD, Yang JM, Hahn MJ

  • KMID: 756067
  • Exp Mol Med.
  • 2007 Aug;39(4):450-457.
Zinc finger protein 133 (ZNF133) is composed of a Kruppel-associated box (KRAB) domain and 14 contiguous zinc finger motifs. ZNF133 is regarded as a transcriptional repressor because the KRAB domain...
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Comparison of Exon-boundary Old and Young Domains during Metazoan Evolution

Lee B

  • KMID: 2053232
  • Genomics Inform.
  • 2009 Jun;7(2):131-135.
Domains are the building blocks of proteins. Exon shuffling is an important mechanism accounting for combination of a limited repertoire of protein domains in the evolution of multicellular species. A...
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In Vitro and In Vivo Effect of Parathyroid Hormone Analogue (1-14) Containing alpha-amino-iso-butyric Acid Residue (Aib)1,3

Rhee Y, Lee W, Lee EJ, Ma S, Park SY, Lim SK

Firstly, parathyroid hormone (1-14) [PTH (1-14)] analogue containing various alpha-amino-iso-butyric acid residue (Aib) was synthesized by exchanging the 1st and 3rd Ala residues of alpha carbon of PTH (1-14). This...
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