- Regulation of Wnt signaling by protein-protein interaction and post-translational modifications
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Kikuchi A, Kishida S, Yamamoto H
- KMID: 1105271
- Exp Mol Med.
- 2006 Feb;38(1):1-10.
The Wnt signaling pathway is conserved in various species from worms to mammals, and plays important roles in cellular proliferation, differentiation, and migration. Wnt stabilizes cytoplasmic beta-catenin and then the... -
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- Post-Translational Modification of Proteins in Toxicological Research: Focus on Lysine Acylation
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Lee S
- KMID: 2317819
- Toxicol Res.
- 2013 Jun;29(2):81-86.
Toxicoproteomics integrates the proteomic knowledge into toxicology by enabling protein quantification in biofluids and tissues, thus taking toxicological research to the next level. Post-translational modification (PTM) alters the three-dimensional (3D)... -
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- Post-Translational Modifications of Cardiac Mitochondrial Proteins in Cardiovascular Disease: Not Lost in Translation
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Marquez J, Lee SR, Kim N, Han J
- KMID: 2223763
- Korean Circ J.
- 2016 Jan;46(1):1-12.
- doi: 10.4070/kcj.2016.46.1.1
Protein post-translational modifications (PTMs) are crucial in regulating cellular biology by playing key roles in processes such as the rapid on and off switching of signaling network and the regulation... -
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- Rescue of Heart Failure by Mitochondrial Recovery
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Marquez J, Lee SR, Kim N, Han J
- KMID: 2173121
- Int Neurourol J.
- 2016 Mar;20(1):5-12.
- doi: 10.5213/inj.1632570.285
Heart failure (HF) is a multifactorial disease brought about by numerous, and oftentimes complex, etiological mechanisms. Although well studied, HF continues to affect millions of people worldwide and current treatments... -
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- Conjugation and deconjugation of ubiquitin regulating the destiny of proteins
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Baek KH
- KMID: 1088651
- Exp Mol Med.
- 2003 Feb;35(1):1-7.
The homeostasis for a number of cellular proteins is regulated by not only phosphorylation and dephosphorylation, but also ubiquitination and deubiquitination. A number of proteins involved in the degradation of... -
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- Cell-free expression and functional reconstitution of CALM in clathrin assembly
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Kim JA, Kim HL
- KMID: 1085745
- Exp Mol Med.
- 2001 Jun;33(2):89-94.
Clathrin-mediated vesicle formation is an essential step in the intracellular trafficking of the protein and lipid. Binding of clathrin assembly protein to clathrin triskelia induces their assembly into clathrin-coated vesicles... -
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- Arginine methylation as a key post-translational modification in skeletal muscle homeostasis: a review
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Kim H, Kang JS, Jeong HJ
- KMID: 2470434
- Precis Future Med.
- 2019 Dec;3(4):139-145.
- doi: 10.23838/pfm.2019.00107
Arginine methylation mediated by protein arginine methyltransferases (PRMTs) has emerged as a key post-translational modification of histone or nonhistone substrates. It involves or controls signaling pathways or gene expression implicated... -
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- Telomerase Activity is Constitutively Expressed in the Murine CD8+ T Cells and Controlled Transcriptionally and Post-Translationally
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Kim S, Kim M, Kim K
- KMID: 2167978
- Immune Netw.
- 2004 Sep;4(3):166-175.
- doi: 10.4110/in.2004.4.3.166
BACKGROUND: Telomerase, a ribonucleoprotein enzyme capable of synthesizing telomeric repeats, attracts attention for its possible role in determining the replicative capacity of normal somatic cells, transformed cells, and cells of... -
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- Modulation of the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor Gamma by Protein-Protein Interactions and Post-Translational Modifications
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Kim TH, Kim MY, Jo SH, Park JM, Ahn YH
- KMID: 1727863
- Yonsei Med J.
- 2013 May;54(3):545-559.
- doi: 10.3349/ymj.2013.54.3.545
Peroxisome proliferator-activated receptor gamma (PPARgamma) belongs to a nuclear receptor superfamily; members of which play key roles in the control of body metabolism principally by acting on adipose tissue. Ligands... -
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- Dynamic Regulation of APE1/Ref-1 as a Therapeutic Target Protein
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Choi S, Joo HK, Jeon BH
- KMID: 2164316
- Chonnam Med J.
- 2016 May;52(2):75-80.
- doi: 10.4068/cmj.2016.52.2.75
Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1) is a multifunctional protein that plays a central role in the cellular response to DNA damage and redox regulation against oxidative stress. APE1/Ref-1 functions in... -
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- Targeting the Peroxisome Proliferator-Activated Receptor-gamma to Counter the Inflammatory Milieu in Obesity
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Corzo C, Griffin PR
- KMID: 2174220
- Diabetes Metab J.
- 2013 Dec;37(6):395-403.
- doi: 10.4093/dmj.2013.37.6.395
Adipose tissue, which was once viewed as a simple organ for storage of triglycerides, is now considered an important endocrine organ. Abnormal adipose tissue mass is associated with defects in... -
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- Regulation and Role of EZH2 in Cancer
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Yamaguchi , Hung MC
- KMID: 2167686
- Cancer Res Treat.
- 2014 Jul;46(3):209-222.
Polycomb repressive complex 2 (PRC2) is the epigenetic regulator that induces histone H3 lysine 27 methylation (H3K27me3) and silences specific gene transcription. Enhancer of zeste homolog 2 (EZH2) is an... -
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- Overexpression of nicotinamide N-methyltransferase in gastric cancer tissues and its potential post-translational modification
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Lim BH, Cho BI, Kim YN, Kim JW, Park ST, Lee CW
- KMID: 1098079
- Exp Mol Med.
- 2006 Oct;38(5):455-465.
Gastric cancer is one of the most common cancers worldwide. The purpose of this study was to find out potential markers for gastric cancer. Tumor and normal tissues from 152... -
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- The Heterochromatin-1 Phosphorylation Contributes to TPA-Induced AP-1 Expression
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Choi WJ
- KMID: 2170624
- Biomol Ther.
- 2014 Jul;22(4):308-313.
Activator protein-1 (AP-1) is an inducible transcription factor that contributes to the generation of chronic inflammation in response to oxidative and electrophilic stress. Previous studies have demonstrated that the PI3K/Akt1... -
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- Multifactorial Regulation of G Protein-Coupled Receptor Endocytosis
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Zhang X, Kim KM
- KMID: 2367617
- Biomol Ther.
- 2017 Jan;25(1):26-43.
- doi: 10.4062/biomolther.2016.186
Endocytosis is a process by which cells absorb extracellular materials via the inward budding of vesicles formed from the plasma membrane. Receptor-mediated endocytosis is a highly selective process where receptors... -
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- Enzymatic characterization of Mycobacterium smegmatis ADP-ribosyltransferase
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Song EK, Lee SY, Cho JK, Han MK, Lee HH
- KMID: 2054972
- J Bacteriol Virol.
- 2003 Dec;33(4):293-300.
ADP-ribosyltransferase (ADPRT) catalyzes the reaction in which the ADP-ribose moiety of beta-NAD+ is transferred to specific amino acid residues in target proteins. The ADPRT of Mycobacterium smegmatis has been known... -
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- Effect of Nitric Oxide on ADP-ribose Pyrophosphatase Activity
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Kim JH
- KMID: 1846706
- Immune Netw.
- 2005 Dec;5(4):199-204.
- doi: 10.4110/in.2005.5.4.199
BACKGROUND: ADP-ribosyl pyrophosphatases (ADPRase) has been known to catalyze the hydrolysis of ADP-ribose to ribose-5-phosphate and AMP. The role of ADPRase has been suggested to sanitize the cell by removing... -
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- Peptidylarginine Deiminase and Citrullination: Potential Therapeutic Targets for Inflammatory Diseases
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Jang B, Shin SJ
- KMID: 2286269
- J Bacteriol Virol.
- 2013 Sep;43(3):159-167.
- doi: 10.4167/jbv.2013.43.3.159
The multiple post-translational modifications of proteins display specific gain- or loss-of-function under normal and abnormal conditions. These modifications are precisely regulated by post-translational modification enzymes. The altered molecular status perturbs... -
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- Epigenetic regulation and chromatin remodeling in learning and memory
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Kim S, Kaang BK
- KMID: 2367527
- Exp Mol Med.
- 2017 Jan;49(1):e281.
- doi: 10.1038/emm.2016.140
Understanding the underlying mechanisms of memory formation and maintenance has been a major goal in the field of neuroscience. Memory formation and maintenance are tightly controlled complex processes. Among the... -
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- Mammalian Molecular Clocks
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Kwon I, Choe HK, Son GH, Kim K
- KMID: 2165342
- Exp Neurobiol.
- 2011 Mar;20(1):18-28.
- doi: 10.5607/en.2011.20.1.18
As a consequence of the Earth's rotation, almost all organisms experience day and night cycles within a 24-hr period. To adapt and synchronize biological rhythms to external daily cycles, organisms... -
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