- Cilostazol Protects Endothelial Cells Against Lipopolysaccharide-Induced Apoptosis Through ERK1/2- and P38 MAPK-Dependent Pathways
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Lim JH, Woo JS, Shin YW
- KMID: 1717961
- Korean J Intern Med.
- 2009 Jun;24(2):113-122.
- doi: 10.3904/kjim.2009.24.2.113
BACKGROUND/AIMS: We examined the effects of cilostazol on mitogen-activated protein kinase (MAPK) activity and its relationship with cilostazol-mediated protection against apoptosis in lipopolysaccharide (LPS)-treated endothelial cells. METHODS: Human umbilical vein... -
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- Pseudolaric acid B induces apoptosis via activation of c-Jun N-terminal kinase and caspase-3 in HeLa cells
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Gong X, Wang M, Wu Z, Tashiro SI, Onodera S, Ikejima T
- KMID: 1103322
- Exp Mol Med.
- 2004 Dec;36(6):551-556.
Pseudolaric acid B was isolated from Pseudolarix kaempferi Gordon (Pinaceae) and was evaluated for the anti-cancer effect in HeLa cells. We observed that pseudolaric acid B inhibited cell proliferation and... -
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- The effect of 5-aminoimidazole-4-carboxamide-ribonucleoside was mediated by p38 mitogen activated protein kinase signaling pathway in FRO thyroid cancer cells
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Kim WG, Choi HJ, Kim TY, Shong YK, Kim WB
- KMID: 2070111
- Korean J Intern Med.
- 2014 Jul;29(4):474-481.
BACKGROUND/AIMS: 5'-Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a cellular energy sensor that monitors intracellular AMP/adenosine triphosphate (ATP) ratios and is a key regulator of the proliferation and survival of... -
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- Role of PKG-L-type calcium channels in the antinociceptive effect of intrathecal sildenafil
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Kim WM, Yoon MH, Cui JH
- KMID: 1110855
- J Vet Sci.
- 2010 Jun;11(2):103-106.
- doi: 10.4142/jvs.2010.11.2.103
Sildenafil increases the cyclic guanosine monophosphate (cGMP) by inhibition of a phosphodiesterase 5, thereby leading to an antinociceptive effect. The increased cGMP may exert the effect on an L-type calcium... -
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- The translation inhibitor anisomycin induces Elk-1-mediated transcriptional activation of egr-1 through multiple mitogen-activated protein kinase pathways
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Shin SY, Lee JH, Min B, Lee YH
- KMID: 1115946
- Exp Mol Med.
- 2006 Dec;38(6):677-685.
The early growth response-1 gene (egr-1) encodes a zinc-finger transcription factor Egr-1 and is rapidly inducible by a variety of extracellular stimuli. Anisomycin (ANX), a protein synthesis inhibitor, stimulates mitogen-activated... -
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- Involvement of protein kinase C pathway in UVC-stimulated phospholipase D2 activity in Vero 76 cells
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Kim S, Choi MS, Choi MU
- KMID: 1089451
- Exp Mol Med.
- 2005 Oct;37(5):418-426.
Phospholipase D (PLD) activity is known to be related to oxidant-induced cellular signaling and membrane disturbance. Previously, an induction of PLD activity in various cell lines by X-ray irradiation was... -
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- A functional comparison between the HER2high/HER3 and the HER2low/HER3 dimers on heregulin-beta1-induced MMP-1 and MMP-9 expression in breast cancer cells
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Kim S, Han J, Shin I, Kil WH, Lee JE, Nam SJ
- KMID: 1387358
- Exp Mol Med.
- 2012 Aug;44(8):473-482.
Overexpression of HER2 correlates with more aggressive tumors and increased resistance to cancer chemotherapy. However, a functional comparison between the HER2high/HER3 and the HER2low/HER3 dimers on tumor metastasis has not... -
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- Impact of Lysophosphatidylcholine on the Plasminogen Activator System in Cultured Vascular Smooth Muscle Cells
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Yoon BK, Kang YH, Oh WJ, Park K, Lee DY, Choi D, Kim DK, Lee Y, Rhyu MR
- KMID: 2157928
- J Korean Med Sci.
- 2012 Jul;27(7):803-810.
- doi: 10.3346/jkms.2012.27.7.803
The balance between tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor type 1 (PAI-1) regulates fibrinolysis. PAI-1 expression increases in atherosclerotic arteries and vascular smooth muscle cells (VSMCs) are one... -
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- Fucoidan promotes osteoblast differentiation via JNK- and ERK-dependent BMP2-Smad 1/5/8 signaling in human mesenchymal stem cells
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Kim BS, Kang HJ, Park JY, Lee J
- KMID: 2155393
- Exp Mol Med.
- 2015 Jan;47(1):e128.
- doi: 10.1038/emm.2014.95
Fucoidan has attracted attention as a potential drug because of its biological activities, which include osteogenesis. However, the molecular mechanisms involved in the osteogenic activity of fucoidan in human alveolar... -
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- Angiotensin III increases monocyte chemoattractant protein-1 expression in cultured human proximal tubular epithelial cells
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Kim HW, Kim YO, Yoon SA, Han JS, Chun HB, Kim YS
- KMID: 2373780
- Korean J Intern Med.
- 2016 Jan;31(1):116-124.
- doi: 10.3904/kjim.2016.31.1.116
BACKGROUND/AIMS: We investigated whether angiotensin III (Ang III) is involved in monocyte recruitment through regulation of the chemokine monocyte chemoattractant protein-1 (MCP-1) in cultured human proximal tubular epithelial cells (HK-2... -
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- Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase
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Sung DJ, Noh HJ, Kim JG, Park SW, Kim B, Cho H, Bae YM
- KMID: 2154286
- Exp Mol Med.
- 2013 Dec;45(12):e67.
Serotonin (5-hydroxytryptamine (5-HT)) is a neurotransmitter that regulates a variety of functions in the nervous, gastrointestinal and cardiovascular systems. Despite such importance, 5-HT signaling pathways are not entirely clear. We... -
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- p21Cip/WAF1 activation is an important factor for the ERK pathway dependent anti-proliferation of colorectal cancer cells
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Park KS, Jeon SH, Oh JW, Choi KY
- KMID: 1103323
- Exp Mol Med.
- 2004 Dec;36(6):557-562.
p21Cip/WAF1, an important regulator of cell proliferation, is induced by both p53- and extracellular signal regulated kinase (ERK) pathways. The induction of p21Cip/WAF1 occurs by prolonged activation of the ERKs... -
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- Downstream molecular events in the altered profiles of lysophosphatidic acid-induced cAMP in senescent human diploid fibroblasts
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Jang IS, Rhim JH, Park SC, Yeo EJ
- KMID: 1111406
- Exp Mol Med.
- 2006 Apr;38(2):134-143.
Lysophosphatidic acid (LPA) is a phospholipid growth factor that acts through G-protein-coupled receptors. Previously, we demonstrated an altered profile of LPA-dependent cAMP content during the aging process of human diploid... -
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- The Inhibition of Insulin-stimulated Proliferation of Vascular Smooth Muscle Cells by Rosiglitazone Is Mediated by the Akt-mTOR-P70S6K Pathway
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Park S, Lim S, Chang W, Song H, Lee S, Song BW, Kim HJ, Cha MJ, Choi E, Jang Y, Chung N, Cho SY, Hwang KC
- KMID: 1793194
- Yonsei Med J.
- 2008 Aug;49(4):592-600.
- doi: 10.3349/ymj.2008.49.4.592
PURPOSE: Thiazolidinediones (TZDs) are known to inhibit the proliferation of vascular smooth muscle cell (VSMC) by increasing the activity of p27(Kip1) and retinoblastoma protein (RB). However, the upstream signaling mechanisms... -
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- Human Cytomegalovirus IE1 Protein Enhances Herpes Simplex Virus Type 1-induced Syncytial Formation in U373MG Cells
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Shin KC, Park CG, Hwang ES, Cha CY
- KMID: 1107532
- J Korean Med Sci.
- 2008 Dec;23(6):1046-1052.
- doi: 10.3346/jkms.2008.23.6.1046
Co-infection of herpes simplex virus type 1 (HSV-1) and human cytomegalovirus (HCMV) is not uncommon in immunocompromised hosts. Importantly, organ transplant recipients concurrently infected with HSV-1 and HCMV have a... -
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- Apoptotic Effects of Genistein, Biochanin-A and Apigenin on LNCaP and PC-3 Cells by p21 through Transcriptional Inhibition of Polo-like Kinase-1
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Seo YJ, Kim BS, Chun SY, Park YK, Kang KS, Kwon TG
- KMID: 1123450
- J Korean Med Sci.
- 2011 Nov;26(11):1489-1494.
- doi: 10.3346/jkms.2011.26.11.1489
Natural isoflavones and flavones are important dietary factors for prostate cancer prevention. We investigated the molecular mechanism of these compounds (genistein, biochanin-A and apigenin) in PC-3 (hormone-independent/p53 mutant type) and... -
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- An antioxidant modulates expression of receptor activator of NF-kappaB in asthma
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Lee KS, Park HS, Park SJ, Kim SR, Min KH, Jin SM, Li L, Lee YC
- KMID: 1094147
- Exp Mol Med.
- 2006 Jun;38(3):217-229.
Oxidative stress plays critical roles in airway inflammation that is usually accompanied by increased vascular permeability and plasma exudation. VEGF increases vascular permeability and leads to airway inflammation. In addition,... -
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