- Angiotensin II Modulates p130Cas of Podocytes by the Suppression of AMP-Activated Protein Kinase
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Ha TS, Park HY, Seong SB, Ahn HY
- KMID: 2363691
- J Korean Med Sci.
- 2016 Apr;31(4):535-541.
- doi: 10.3346/jkms.2016.31.4.535
Angiotensin II (Ang II) induces the pathological process of vascular structures, including renal glomeruli by hemodynamic and nonhemodynamic direct effects. In kidneys, Ang II plays an important role in the... -
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- beta-TrCP1 degradation is a novel action mechanism of PI3K/mTOR inhibitors in triple-negative breast cancer cells
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Yi YW, Kang HJ, Bae EJ, Oh S, Seong YS, Bae I
- KMID: 2155408
- Exp Mol Med.
- 2015 Feb;47(2):e143.
- doi: 10.1038/emm.2014.127
An F-box protein, beta-TrCP recognizes substrate proteins and destabilizes them through ubiquitin-dependent proteolysis. It regulates the stability of diverse proteins and functions as either a tumor suppressor or an oncogene.... -
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- Anti-Proliferative Effects of Rutin on OLETF Rat Vascular Smooth Muscle Cells Stimulated by Glucose Variability
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Yu SH, Yu JM, Yoo HJ, Lee SJ, Kang DH, Cho YJ, Kim DM
- KMID: 2374042
- Yonsei Med J.
- 2016 Mar;57(2):373-381.
- doi: 10.3349/ymj.2016.57.2.373
PURPOSE: Proliferation of vascular smooth muscle cells (VSMCs) plays a crucial role in atherosclerosis. Rutin is a major representative of the flavonol subclass of flavonoids and has various pharmacological activities.... -
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- Could HBx Protein Expression Affect Signal Pathway Inhibition by Gefitinib or Selumetinib, a MEK Inhibitor, in Hepatocellular Carcinoma Cell Lines?
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Park YK, Kim KM, Lee YJ, Kim KH, Lee SG, Lee D, Shim JH, Lim YS, Lee HC, Chung YH, Lee YS, Suh DJ
- KMID: 1782109
- J Korean Med Sci.
- 2011 Feb;26(2):214-221.
- doi: 10.3346/jkms.2011.26.2.214
Hepatitis B virus X (HBx) protein has been known to play an important role in development of hepatocellular carcinoma (HCC). The aim of this study is to find out whether... -
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- Potential Antitumor Activity of SIM-89 in Non-Small Cell Lung Cancer Cells
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Pei J, Chu T, Shao M, Teng J, Sha H, Gu A, Li R, Qian J, Mao W, Li Y, Han B
- KMID: 2419116
- Yonsei Med J.
- 2017 May;58(3):581-591.
- doi: 10.3349/ymj.2017.58.3.581
PURPOSE: c-Met and its ligand, hepatocyte growth factor (HGF), play a critical role in oncogenesis and metastatic progression. The aim of this study was to identify inhibited enzymogram and to... -
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- Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells
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Kim DS, Na YJ, Kang MH, Yoon SY, Choi CW
- KMID: 2373811
- Korean J Intern Med.
- 2016 Mar;31(2):357-366.
- doi: 10.3904/kjim.2015.024
BACKGROUND/AIMS: The treatment of chronic myeloid leukemia (CML) has achieved impressive success since the development of the Bcr-Abl tyrosine kinase inhibitor, imatinib mesylate. Nevertheless, resistance to imatinib has been observed,... -
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- Prevention of TNF-induced necrotic cell death by rottlerin through a Nox1 NADPH oxidase
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Byun HS, Won M, Park KA, Kim YR, Choi BL, Lee H, Hong JH, Piao L, Park J, Kim JM, Kweon GR, Kang SH, Han J, Hur GM
- KMID: 1052941
- Exp Mol Med.
- 2008 Apr;40(2):186-195.
- doi: 10.3858/emm.2008.40.2.186
Previous studies have demonstrated that rottlerin, a specific PKCdelta inhibitor, potentiates death receptor- mediated apoptosis through a cytochrome c-dependent or -independent pathway. However, its ability to regulate necrotic cell death,... -
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- Emodin ameliorates high-glucose induced mesangial p38 over-activation and hypocontractility via activation of PPARgamma
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Liu Y, Jia L, Liu ZC, Zhang H, Zhang PJ, Wan Q, Wang R
- KMID: 756208
- Exp Mol Med.
- 2009 Sep;41(9):648-655.
- doi: 10.3858/emm.2009.41.9.071
Early stage diabetic nephropathy is characterized by elevated glomerular filtration. Recent studies have identified high-glucose induced p38 MAPK (p38) over-activation in mesangial cells. Mesangial hypocontractility is the major underlying mechanism,... -
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