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Involvement of Protein Kinase C-delta in Vascular Permeability in Acute Lung Injury

Ahn JJ, Jung JP, Park SE, Lee M, Kwon B, Cho HR

Pulmonary edema is a major cause of mortality due to acute lung injury (ALI). The involvement of protein kinase C-delta (PKC-delta) in ALI has been a controversial topic. Here we...
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Role of Protein Kinase C-delta in Atherosclerosis

Park SJ, Jung JP, Kim HJ, Lee EA, Kwon TW, Kwon B, Cho HR

PURPOSE: Protein kinase C (PKC) has been implicated in a wide variety of cellular processes. Although PKC-delta is implicated in cell growth inhibition, as well as in cell differentiation, apoptosis,...
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Transcription of the protein kinase C-delta gene is activated by JNK through c-Jun and ATF2 in response to the anticancer agent doxorubicin

Min BW, Kim CG, Ko J, Lim Y, Lee YH, Shin SY

Expression of protein kinase C-delta (PKC delta) is up-regulated by apoptosis-inducing stimuli. However, very little is known about the signaling pathways that control PKC delta gene transcription. In the present...
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Protein Kinase C-delta Mediates Nitric Oxide- induced Proliferation of Gastric Cancer Cells, MKN-2

Kim HH, Park KJ, Kwak JY

  • KMID: 2004571
  • J Korean Surg Soc.
  • 2003 Mar;64(3):194-200.
PURPOSE: The purpose of this study was to investigate the effect of exogenous nitric oxide (NO) on the proliferation of gastric carcinoma cells and the signaling pathways that regulate these...
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Involvement of Protein Kinase C delta in Iron Chelator-Induced IL-8 Production in Human Intestinal Epithelial Cells

Sohn YW, Choi EY, Han WC, Yun KJ, Oh JM, Jun CD

  • KMID: 2030768
  • Korean J Anat.
  • 2005 Feb;38(1):21-30.
Our previous study demonstrated that a bacterial siderophore, deferoxamine (DFO), could trigger inflammatory signals in human intestinal epithelial cells as a single stimulus, leading to IL-8 production via ERK1/2 and...
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Rottlerin enhances IL-1beta-induced COX-2 expression through sustained p38 MAPK activation in MDA-MB-231 human breast cancer cells

Park EJ, Kwon TK

Cyclooxygenase-2 (COX-2) is an important enzyme in inflammation. In this study, we investigated the underlying molecular mechanism of the synergistic effect of rottlerin on interleukin1beta (IL-1beta)-induced COX-2 expression in MDA-MB-231...
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Down-regulation of Membrane Bound CD27 Expression Mediated by Protein Kinase C-beta and Protein Kinase C-delta in B Cells

Lee SY, Min JK, Cho ML, Moon YM, Kim KW, Min SY, Cho YG, Yoon CH, Park SH, Kim HY

  • KMID: 2202281
  • J Korean Rheum Assoc.
  • 2006 Mar;13(1):33-45.
OBJECTIVE: CD27 is a member of the tumor necrosis factor receptor (TNFR) superfamily and is expressed on T, B, and NK cells. The signaling via CD27 plays pivotal roles in...
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Mycophenolic acid mediated mitochondrial membrane potential transition change lead to T lymphocyte apoptosis

Choi SJ, Lee HK, Kim NH, Chung SY

PURPOSE: This study demonstrated that apoptosis induced by mycophenolic acid (MPA) is mediated by mitochondrial membrane potential transition (MPT) changes in Jurkat cells. METHODS: Cell viability and MPT changes were measured...
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Cell type-specific upregulation of myristoylated alanine-rich C kinase substrate and protein kinase C-alpha, -beta I, -beta II, and -delta in microglia following kainic acid-induced seizures

Eun SY, Kim EH, Kang KS, Kim HJ, Jo SA, Kim SJ, Jo SH, Kim SJ, Blackshear PJ, Kim J

  • KMID: 1094157
  • Exp Mol Med.
  • 2006 Jun;38(3):310-319.
Myristoylated alanine-rich C kinase substrate (MARCKS) is a widely distributed protein kinase C (PKC) substrate and has been implicated in actin cytoskeletal rearrangement in response to extracellular stimuli. Although MARCKS...
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