- Proteolytic Regulation of Retinoblastoma Family Protein p107 by Ubiquitin - proteasome Pathway
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Jang JS, Park BK, Hwang SG
- KMID: 2175114
- J Korean Cancer Assoc.
- 2000 Apr;32(2):417-421.
PURPOSE: Proteolysis is an important way to regulate cell cycle regulatory proteins. Ubiquitin- proteasome pathway regards as highly selective proteolytic machinary mostly in physiological state. We investigated the role of ubiquitin-proteasome pathway... -
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- Inhibition of the 26S and 20S Proteasomes by the Site-specific Inhibitors
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Woo KM
- KMID: 2437766
- Soonchunhyang Med Sci.
- 2018 Jun;24(1):47-54.
- doi: 10.0000/sms.2018.24.1.47
OBJECTIVE: The study was performed to establish the purification processes of both 26S and 20S proteasomes, also to investigate the inhibitory properties and patterns of two different proteasome inhibitors on... -
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- Apoptotic Effect of Combination Treatment with a Proteasome Inhibitor, Lactacystin, and a Histone Deacetylase Inhibitor, Trichostatin A, on MCF-7 Cells
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Kim GC, Shin YJ, Kim IR, Lee MH, Hwang YS, Gil YG, Park BS
- KMID: 1510218
- Korean J Anat.
- 2006 Dec;39(6):443-452.
Although much information has been accumulated about the synergistic interaction of proteasome inhibitors and HDAC inhibitors to induce apoptosis in a certain type of cells, much less is known currently... -
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- Inhibitory Effect of Apocynin on Proteasome Inhibition-Induced Apoptosis in Differentiated PC12 Cells
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Kang JH, Han SW, Han JH, Kim DE, Lee CS
- KMID: 2163256
- J Korean Neurol Assoc.
- 2016 May;34(2):116-123.
- doi: 10.17340/jkna.2016.2.5
BACKGROUND: The dysfunction of the proteasome system has been implicated in neuronal degeneration. Apocynin, a specific inhibitor for nicotinamide adenine dinucleotide phosphate oxidase, has anti-inflammatory and anti-oxidant effects. However, the... -
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- The Mechanism of Proteasome Inhibitor-Induced Apoptosis in Lung Cancer Cells
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Kim CH, Lee KH, Lee CT, Kim YW, Han SK, Shim YS, Yoo CG
- KMID: 2318413
- Tuberc Respir Dis.
- 2003 Apr;54(4):403-414.
BACKGROUND: Proteasome inhibitors can promote either cell survival or programmed cell death, depending on both the specific type and proliferative status of the cell. However, it is not well known... -
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- Selective Susceptibility of Human Dopaminergic Neural Stem Cells to Dopamine-Induced Apoptosis
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Jeon SM, Cheon SM, Bae HR, Kim JW, Kim SU
- KMID: 1460760
- Exp Neurobiol.
- 2010 Dec;19(3):155-164.
- doi: 10.5607/en.2010.19.3.155
Dysfunctions of ubiquitin-proteasome system and toxicity of dopamine have been known as the key mechanisms in the pathogenesis of Parkinson's disease (PD) and proteasome inhibitors are widely used in experimental... -
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- HIF-1alpha Upregulation due to Depletion of the Free Ubiquitin Pool
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Kim J, So D, Shin HW, Chun YS, Park JW
- KMID: 2344170
- J Korean Med Sci.
- 2015 Oct;30(10):1388-1395.
- doi: 10.3346/jkms.2015.30.10.1388
Hypoxia-inducible factor 1alpha (HIF-1alpha), which transactivates a variety of hypoxia-induced genes, is rapidly degraded under nomoxia through the hydroxylation-ubiquitination-proteasome pathway. In this study, we addressed how HIF-1alpha is stabilized by... -
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- The Role of the Ubiquitin-Proteasome Pathway in Neurodegenerative Disorders
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Choi K, Choi C
- KMID: 2185761
- J Korean Neurol Assoc.
- 2003 Dec;21(6):573-583.
Impaired function of the Ubiquitin (Ub)/proteasome pathway is one of the molecular mechanisms underlying aging process and neurodegenerative disorders such as Parkinson's Disease and Alzheimer's Disease (AD). Among many vital... -
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- Effect of Lactacystin on the Sulindac-Induced Apoptosis Mechanisms in HT-29 Cells
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Kim JM, Park KJ, Kim SH, Choi HJ
- KMID: 2334296
- J Korean Soc Coloproctol.
- 2003 Apr;19(2):61-66.
PURPOSE: One of possible mechanisms of the antineoplastic effect by nonsteroidal anti-inflammatory drugs (NSAIDs) is an induction of apoptosis. The NSAIDs-induced apoptosis appears to be caspase- and mitochondria-dependent. The ubiquitin-proteasome... -
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- A Case of Acute Pancreatitis Caused by Bortezomib in a Patient with Multiple Myeloma
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Lim JH, Hwang KB, Lim BH, Jeong YH, Sohn KC, Kim TH
- KMID: 2448488
- Korean J Pancreas Biliary Tract.
- 2015 Jul;20(3):136-139.
- doi: 10.15279/kpba.2015.20.3.136
Bortezomib is a proteasome inhibitor used for the treatment of patients with multiple myeloma. Recently, several case reports about acute pancreatitis caused by Bortezomib were published in the international literature.... -
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- A Case of Cutaneous Plasmacytoma Treated with Bortezomib and Radiotherapy
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Jeong KH, Yoon HJ, Lee MH
- KMID: 2247932
- Korean J Dermatol.
- 2009 Apr;47(4):483-486.
Multiple myeloma is a hematologic malignancy characterized by the proliferation of monoclonal plasma cells that produce monoclonal immunoglobulins. Cutaneous involvement is very uncommon in patients with multiple myeloma. It usually... -
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- Optimal maintenance and consolidation therapy for multiple myeloma in actual clinical practice
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Lee HS, Min CK
- KMID: 2350969
- Korean J Intern Med.
- 2016 Sep;31(5):809-819.
- doi: 10.3904/kjim.2016.110
Multiple myeloma is an incurable malignant plasma cell-originating cancer. Although its treatment outcomes have improved with the use of glucocorticoids, alkylating drugs, and novel agents, including proteasome inhibitors (bortezomib and... -
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- Novel Agents for Treatment of Multiple Myeloma
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Kim HJ
- KMID: 2082582
- Korean J Med.
- 2015 Mar;88(3):252-257.
- doi: 10.3904/kjm.2015.88.3.252
Multiple myeloma (MM) is a neoplasm of clonal plasma cells that closely interacts with the bone marrow (BM) microenvironment. The overall survival of patients with MM has improved dramatically in... -
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- Two Cases of Bortezomib-induced Drug Eruption Presenting as Multiple Plaques on the Trunk
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Choe YS, Kim EJ, Na JI
- KMID: 2245828
- Korean J Dermatol.
- 2016 Jan;54(1):47-51.
Bortezomib (Velcade(R)) is proteasome inhibitor that is used as a first-line therapy for multiple myeloma. It can cause gastrointestinal, hematologic, and neuromuscular side effects, and a cutaneous reaction is one... -
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- Effects of a Proteasome Inhibitor on Cardiomyocytes in a Pressure-Overload Hypertrophy Rat Model: An Animal Study
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Kim IS, Jo WM
- KMID: 2381896
- Korean J Thorac Cardiovasc Surg.
- 2017 Jun;50(3):144-152.
- doi: 10.5090/kjtcs.2017.50.3.144
BACKGROUND: The ubiquitin-proteasome system (UPS) is an important pathway of proteolysis in pathologic hypertrophic cardiomyocytes. We hypothesize that MG132, a proteasome inhibitor, might prevent hypertrophic cardiomyopathy (CMP) by blocking the... -
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- Effects of Hypoxia on the Ubiquitin-proteasome System in Primary Cortical Neuronal Cell Cultures
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Yang SJ, Kim MJ, Jeong HJ, Kim GC, Gil YG, Kim KR, Kim H
- KMID: 1481577
- Korean J Phys Anthropol.
- 2008 Mar;21(1):21-29.
The ubiquitin-proteasome system is crucial in maintaining cellular growth and metabolism. Dysfunction of this system may contribute to neurodegenerative diseases, such as Parkinson's disease. But its effects on primary neurons... -
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- Proteasome-Inhibitor-Based Primary Therapy for Antibody-Mediated Rejection in a Renal Transplant Recipient
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Park SJ, Yu H, Kang SH, Baek SD, Baek CH, Jeong JH, Park SK
- KMID: 2264162
- Korean J Med.
- 2011 Dec;81(6):780-785.
Donor-specific anti-human leukocyte antigen antibodies (DSA) following kidney transplantation predict the evolution of humoral rejection and reduced graft survival. Rapid, complete elimination of DSA during antibody-mediated rejection (AMR) is rarely... -
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- Medaka Fish Parkinson's Disease Model
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Matsui H, Gavinio R, Takahashi
- KMID: 2134999
- Exp Neurobiol.
- 2012 Sep;21(3):94-100.
- doi: 10.5607/en.2012.21.3.94
The teleost fish has been widely used in creating neurodegenerative models. Here we describe the teleost medaka fish Parkinson's disease (PD) models we developed using toxin treatment and genetic engineering.... -
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- Treatment of Refractory Antibody-mediated Rejection with Bortezomib in a Kidney Transplant Recipient: A Case Report
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Lee JY, Yoo JY, Kwon SH, Jeon JS, Noh H, Han DC, Song D, Jin SY
- KMID: 2202536
- J Korean Soc Transplant.
- 2014 Jun;28(2):87-90.
- doi: 10.4285/jkstn.2014.28.2.87
Antibody-mediated rejection (ABMR) is associated with poor renal allograft survival. It shows poor response to conventional treatment with plasmapheresis, rituximab, and intravenous immunoglobulin. Bortezomib, a proteasome inhibitor used for treatment... -
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- Apoptotic Effect of Co-Treatment with a Natural Product, Chios Gum Mastic, and a Proteasome Inhibitor, Lactacystin, on Human Osteosarcoma Cells
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Baek CJ, Heo JY, Kim GC, Kwak HH, Kim IR, Lee SE, Kim CH, Jeong NY, Park BS
- KMID: 1484903
- Korean J Anat.
- 2008 Jun;41(2):129-138.
Chios gum mastic (CGM) is a resinous exudate obtained from the stem and the main leaves of Pistacia lenticulus tree native to Mediterranean areas. Recently, it was reported that CGM... -
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