- Promoter effects of adeno-associated viral vector for transgene expression in the cochlea in vivo
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Liu Y, Okada T, Nomoto T, Ke X, Kume A, Ozawa K, Xiao S
- KMID: 1094657
- Exp Mol Med.
- 2007 Apr;39(2):170-175.
The aims of this study were to evaluate the expression of enhanced green fluorescent protein (EGFP) driven by 6 different promoters, including cytomegalovirus IE enhancer and chicken beta-actin promoter (CAG),... -
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- Promoter Methylation in the Genesis of Gastrointestinal Cancer
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Boland CR, Shin SK, Goel A
- KMID: 1758556
- Yonsei Med J.
- 2009 Jun;50(3):309-321.
- doi: 10.3349/ymj.2009.50.3.309
Colorectal cancers (CRC)-and probably all cancers-are caused by alterations in genes. This includes activation of oncogenes and inactivation of tumor suppressor genes (TSGs). There are many ways to achieve these... -
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- Persistent α-Fetoprotein Elevation in Healthy Adults and Mutational Analysis of α-Fetoprotein Promoter, Enhancer, and Silencer Regions
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Jeon Y, Choi YS, Jang ES, Kim JW, Jeong SH
- KMID: 2412165
- Gut Liver.
- 2017 Jan;11(1):136-141.
- doi: 10.5009/gnl16069
BACKGROUND/AIMS: α-Fetoprotein (AFP) is normally 1 year, and 20 controls with low AFP levels ( -
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- Lack of Association between Matrix Metalloproteinase 8 Promoter Polymorphism and Bronchiectasis in Koreans
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Lee J, Kim HR, Min JW, Park JS, Jin SM, Han SK, Shim YS, Yim JJ
- KMID: 1127084
- J Korean Med Sci.
- 2007 Aug;22(4):667-671.
- doi: 10.3346/jkms.2007.22.4.667
The observation that human matrix metalloproteinase (MMP)-8 is over-expressed in ectatic bronchi in patients with bronchiectasis suggests that polymorphisms altering the expression of MMP-8 may contribute to the susceptibility to... -
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- Clinical Significance of Aberrant Wnt7a Promoter Methylation in Human Non-Small Cell Lung Cancer in Koreans
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Kim TH, Moon JY, Kim SH, Paik SS, Yoon HJ, Shin DH, Park SS, Sohn JW
- KMID: 2129645
- J Korean Med Sci.
- 2015 Feb;30(2):155-161.
- doi: 10.3346/jkms.2015.30.2.155
The Wnt signaling pathway has regulatory roles in cell proliferation, differentiation, and polarity. Aberrant Wnt pathway regulation can lead to abnormal cell proliferation and cancer, and loss of Wnt7a expression... -
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- TERT Polymorphism rs2853669 Influences on Lung Cancer Risk in the Korean Population
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Yoo SS, Do SK, Choi JE, Lee SY, Lee J, Cha SI, Kim CH, Park JY
- KMID: 2344174
- J Korean Med Sci.
- 2015 Oct;30(10):1423-1428.
- doi: 10.3346/jkms.2015.30.10.1423
Short telomeres are known as one of the risk factors for human cancers. The present study was conducted to evaluate the association between 6 polymorphisms, which were related with short... -
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- Transcriptional activation of insulin-like growth factor binding protein 6 by 17beta-estradiol in SaOS-2 cells
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Zhao YY, Guo L, Zhao XJ, Liu H, Lei T, Ma DJ, Gao XY
- KMID: 1058022
- Exp Mol Med.
- 2009 Jul;41(7):478-486.
- doi: 10.3858/emm.2009.41.7.053
Osteoblasts can synthesize the insulin-like growth factors (IGFs) and the IGF-binding proteins (IGFBPs), which may either enhance or attenuate IGF-stimulated bone cell proliferation. Since estrogen induced osteoblastic differentiation and proliferation... -
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- Common variants at the promoter region of the APOM confer a risk of rheumatoid arthritis
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Hu HJ, Jin EH, Yim SH, Yang SY, Jung SH, Shin SH, Kim WU, Shim SC, Kim TG, Chung YJ
- KMID: 1025164
- Exp Mol Med.
- 2011 Nov;43(11):613-621.
- doi: 10.3858/emm.2011.43.11.068
Although the genetic component in the etiology of rheumatoid arthritis (RA) has been consistently suggested, many novel genetic loci remain to uncover. To identify RA risk loci, we performed a... -
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- Transcriptional targeting of gene expression in breast cancer by the promoters of protein regulator of cytokinesis 1 and ribonuclease reductase 2
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Yun HJ, Cho YH, Moon Y, Park YW, Yoon HK, Kim YJ, Cho SH, Lee YI, Kang BS, Kim WJ, Park K, Seo W
- KMID: 756337
- Exp Mol Med.
- 2008 Jun;40(3):345-353.
- doi: 10.3858/emm.2008.40.3.345
For cancer gene therapy, cancer-specific over-expression of a therapeutic gene is required to reduce side effects derived from expression of the gene in normal cells. To develop such an expression... -
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- Association of the Single-Nucleotide Polymorphism and Haplotype of the Complement Receptor 1 Gene with Malaria
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Lan Y, Wei CD, Chen WC, Wang JL, Wang CF, Pan GG, Wei YS, Nong LG
- KMID: 2070007
- Yonsei Med J.
- 2015 Mar;56(2):332-339.
- doi: 10.3349/ymj.2015.56.2.332
PURPOSE: Although the polymorphisms of erythrocyte complement receptor type 1 (CR1) in patients with malaria have been extensively studied, a question of whether the polymorphisms of CR1 are associated with... -
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- Field Cancerization in Sporadic Colon Cancer
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Park SK, Song CS, Yang HJ, Jung YS, Choi KY, Koo DH, Kim KE, Jeong KU, Kim HO, Kim H, Chun HK, Park DI
- KMID: 2412075
- Gut Liver.
- 2016 Sep;10(5):773-780.
- doi: 10.5009/gnl15334
BACKGROUND/AIMS: Aberrant DNA methylation has a specific role in field cancerization. Certain molecular markers, including secreted frizzled-related protein 2 (SFRP2), tissue factor pathway inhibitor 2 (TFPI2), N-Myc downstream-regulated gene 4... -
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