- Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase
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Sung DJ, Noh HJ, Kim JG, Park SW, Kim B, Cho H, Bae YM
- KMID: 2154286
- Exp Mol Med.
- 2013 Dec;45(12):e67.
Serotonin (5-hydroxytryptamine (5-HT)) is a neurotransmitter that regulates a variety of functions in the nervous, gastrointestinal and cardiovascular systems. Despite such importance, 5-HT signaling pathways are not entirely clear. We... -
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- Characteristics of Potassium and Calcium Currents of Hepatic Stellate Cells (Ito) in Rat
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Lee KI, Kong ID, Baik SK, Kim HS, Lee DK, Kwon SO, Chun BG
- KMID: 721416
- Yonsei Med J.
- 2004 Aug;45(4):649-660.
- doi: 10.3349/ymj.2004.45.4.649
Hepatic stellate cells (HSCs) are known to play a role in the pathogenesis of the increased intrahepatic vascular resistance found in chronic liver diseases. The aim of this study was... -
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- Polyphenol (-)-Epigallocatechin Gallate during Ischemia Limits Infarct Size Via Mitochondrial K(ATP) Channel Activation in Isolated Rat Hearts
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Song DK, Jang Y, Kim JH, Chun KJ, Lee D, Xu Z
- KMID: 1778032
- J Korean Med Sci.
- 2010 Mar;25(3):380-386.
- doi: 10.3346/jkms.2010.25.3.380
Polyphenol (-)-epigallocatechin gallate (EGCG), the most abundant catechin of green tea, appears to attenuate myocardial ischemia/reperfusion injury. We investigated the involvement of ATP-sensitive potassium (K(ATP)) channels in EGCG-induced cardioprotection. Isolated... -
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- Sodium-activated Potassium Current in Guinea pig Gastric Myocytes
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Kim YC, Sim JH, Kang TM, Suzuki H, Kim SR, Kwon SC, Xu WX, Lee SJ, Kim KW
- KMID: 1713230
- J Korean Med Sci.
- 2007 Feb;22(1):57-62.
- doi: 10.3346/jkms.2007.22.1.57
This study was designed to identify and characterize Na+ -activated K+ current (I(K(Na))) in guinea pig gastric myocytes under whole-cell patch clamp. After whole-cell configuration was established under 110 mM... -
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- Cinnamyl alcohol attenuates vasoconstriction by activation of K+ channels via NO-cGMP-protein kinase G pathway and inhibition of Rho-kinase
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Kang YH, Yang IJ, Morgan KG, Shin HM
- KMID: 1402319
- Exp Mol Med.
- 2012 Dec;44(12):749-755.
Cinnamyl alcohol (CAL) is known as an antipyretic, and a recent study showed its vasodilatory activity without explaining the mechanism. Here we demonstrate the vasodilatory effect and the mechanism of... -
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