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Shear-Wave Elastography of the Breast: Added Value of a Quality Map in Diagnosis and Prediction of the Biological Characteristics of Breast Cancer

Zheng X, Huang Y, Liu Y, Wang Y, Mao R, Li F, Cao L, Zhou J

OBJECTIVE: To determine the added value of a shear-wave elastography (SWE) quality map (QM) in the diagnosis of breast lesions and in predicting the biological characteristics of invasive breast cancer. MATERIALS...
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Heterogeneity of Human γδ T Cells and Their Role in Cancer Immunity

Lee HW, Chung YS, Kim TJ

The γδ T cells are unconventional lymphocytes that function in both innate and adaptive immune responses against various intracellular and infectious stresses. The γδ T cells can be exploited as...
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Intrafamilial variability and clinical heterogeneity in a family with PLA2G6-associated neurodegeneration

Park JK, Youn J, Cho JW

Phospholipase A2 group VI (PLA2G6)-associated neurodegeneration (PLAN) is an autosomal recessive neurodegenerative disease with a wide clinical spectrum; however, the genotype-phenotype correlation is unknown. Here, we report different phenotypes in...
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Monitoring Glutathione Dynamics and Heterogeneity in Living Stem Cells

Jeong EM, Shin JW, Lim J, Kim JH, Kang H, Yin Y, Kim HM, Kim Y, Kim SG, Kang HS, Shin DM, Choi K, Kim IG

Glutathione (GSH) is a major antioxidant in cells, and plays vital roles in the cellular defense against oxidants and in the regulation of redox signals. In a previous report, we...
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Effects of TGF-β1 Overexpression on Biological Characteristics of Human Dental Pulp-derived Mesenchymal Stromal Cells

Salkın H, Gönen ZB, Ergen E, Bahar D, Çetin M

OBJECTIVE: The aim of our study was to investigate the effect of Transforming growth factor beta-1 (TGF-β1) gene therapy on the surface markers, multilineage differentiation, viability, apoptosis, cell cycle, DNA...
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Biological characteristics of osteoporosis drugs: the effect of osteoblast–osteoclast coupling

Kim SJ, Moon SJ, Seo JT

Osteoporosis is a common disease characterized by bone mass reduction, leading to an increased risk of bone fracture, and it is caused by an imbalance of osteoblastic bone formation and...
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Assessment of the Clinical Heterogeneity of Kawasaki Disease Using Genetic Variants of BLK and FCGR2A

Sim BK, Park H, Kim JJ, Yun SW, Yu JJ, Yoon KL, Lee KY, Kil HR, Kim GB, Han MK, Song MS, Lee HD, Ha KS, Sohn S, Hong YM, Jang GY, Lee JK, on behalf of the Korean Kawasaki Disease Genetics Consortium

BACKGROUND AND OBJECTIVES: Patients with Kawasaki disease (KD) are clinically heterogeneous because its diagnosis is based solely on clinical observation and there are no definitive biomarkers. We dissected the clinical...
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Clinical Heterogeneity of Anti-GM2-Ganglioside-Antibody Syndrome

Kim JK, Kim YH, Yoon BA, Cho JY, Oh SY, Shin HY, Kim JS, Park KH, Kim SY, Suh BC, Seok HY, Yoo JH, Bae JS

BACKGROUND AND PURPOSE: Antiganglioside antibodies are known to play a pathogenic role in Guillain-Barré syndrome (GBS). Either an immunoglobulin (Ig)G- or IgM-type anti-GM2 antibody is detected in rare cases in...
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Heterogeneity Does Matter for Tumor Characterization

Lee WW

No abstract available.
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Histopathologic heterogeneity of acute respiratory distress syndrome revealed by surgical lung biopsy and its clinical implications

Park J, Lee YJ, Lee J, Park SS, Cho YJ, Lee SM, Kim YW, Han SK, Yoo CG

BACKGROUND/AIMS: Diffuse alveolar damage (DAD) is the histopathologic hallmark of acute respiratory distress syndrome (ARDS). However, there are several non-DAD conditions mimicking ARDS. The purpose of this study was to...
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Cerebral Microbleeds and the Heterogeneity of Parkinson's Disease

Yang HJ

No abstract available.
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Genetic Alterations among Korean Melanoma Patients Showing Tumor Heterogeneity: A Comparison between Primary Tumors and Corresponding Metastatic Lesions

Lee SH, Kim JE, Jang HS, Park KH, Oh BH, Shin SJ, Chung KY, Roh MR, Rha SY

PURPOSE: Melanoma is a highly heterogeneous neoplasm, composed of subpopulations of tumor cells with distinct molecular and biological phenotypes and genotypes. In this study, to determine the genetic heterogeneity between...
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The Author Reply: Genotypic and Phenotypic Heterogeneity of LGMD1D due to DNAJB6 Mutations

Kim K, Choi YC

No abstract available.
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Genotypic and Phenotypic Heterogeneity of LGMD1D due to DNAJB6 Mutations

Finsterer

No abstract available.
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The significance of intertumor and intratumor heterogeneity in liver cancer

Liu J, Dang H, Wang XW

Genomic analyses of primary liver cancer samples reveal a complex mutational landscape with vast intertumor and intratumor heterogeneity. Different primary liver tumors and subclones within each tumor display striking molecular...
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Deciphering cellular and molecular causes of the tumor functional heterogeneity of liver cancer

Nam SW

No abstract available.
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A New Perspective on the Heterogeneity of Cancer Glycolysis

Neugent ML, Goodwin J, Sankaranarayanan I, Yetkin CE, Hsieh MH, Kim JW

Tumors are dynamic metabolic systems which highly augmented metabolic fluxes and nutrient needs to support cellular proliferation and physiological function. For many years, a central hallmark of tumor metabolism has...
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Heterogeneity in Trajectories of Body Mass Index and Their Associations with Mortality in Old Age: A Literature Review

Murayama H, Shaw BA

This article reviewed studies to investigate the association between trajectories of body mass index (BMI) and mortality among older adults. Investigators conducted a systematic search of published peer-reviewed literature in...
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HER2 Status and Its Heterogeneity in Gastric Carcinoma of Vietnamese Patient

Phan DA, Nguyen VT, Hua TN, Ngo QD, Doan TP, Nguyen ST, Thai AT, Nguyen VT

BACKGROUND: Human epidermal growth factor receptor 2 (HER2) is related to the pathogenesis and poor outcome of numerous types of carcinomas, including gastric carcinoma. Gastric cancer patients with HER2 positivity...
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Asthma and the Risk of Rheumatoid Arthritis: An Insight into the Heterogeneity and Phenotypes of Asthma

Rolfes MC, Juhn YJ, Wi CI, Sheen YH

Asthma is traditionally regarded as a chronic airway disease, and recent literature proves its heterogeneity, based on distinctive clusters or phenotypes of asthma. In defining such asthma clusters, the nature...
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