- Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity
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Yoon SP, Kim J
- KMID: 2353341
- Anat Cell Biol.
- 2016 Sep;49(3):165-176.
- doi: 10.5115/acb.2016.49.3.165
Enhanced oxidative stress is a hallmark of cisplatin nephrotoxicity, and inhibition of poly(ADP-ribose) polymerase 1 (PARP1) attenuates oxidative stress during cisplatin nephrotoxicity; however, the precise mechanisms behind its action remain... -
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- Poly(ADP-ribose) polymerase regulates glycolytic activity in kidney proximal tubule epithelial cells
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Song H, Yoon SP, Kim J
- KMID: 2308914
- Anat Cell Biol.
- 2016 Jun;49(2):79-87.
- doi: 10.5115/acb.2016.49.2.79
After renal injury, selective damage occurs in the proximal tubules as a result of inhibition of glycolysis. The molecular mechanism of damage is not known. Poly(ADP-ribose) polymerase (PARP) activation plays... -
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- The Anti-fibrotic Effect of Nilotinib on Tenon's Capsule Fibroblasts in Vitro
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Kang JW, Jeong JH, Moon NJ
- KMID: 2413818
- J Korean Ophthalmol Soc.
- 2018 Jun;59(6):549-555.
- doi: 10.3341/jkos.2018.59.6.549
PURPOSE: To evaluate the anti-fibrotic effects of nilotinib on the survival of cultured human Tenon's capsule fibroblasts (HTFs). METHODS: HTF primary cultures were obtained from samples following glaucoma surgery. Primarily cultured... -
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- Increased Poly (ADP-ribose) Polymerase Activation in the 6-Hydroxydopamine Induced Dopaminergic Neuronal Cell Death
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Kang JH, Kang SY, Park SY, Kang HK, Park DB, Lee YK, Koh JY
- KMID: 2343084
- J Korean Neurol Assoc.
- 2004 Aug;22(4):352-359.
BACKGROUND: The pathological hallmark of Parkinson's disease (PD) is dopaminergic cell death in the substantia nigra (SN), but the cause of cell death is unknown. 6-Hydroxydopamine (6-OHDA) is one of... -
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- Cisplatin-Induced Apoptosis by Cisplatin in Human Glioblastoma Cell Line
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Park JT, Kim TY
- KMID: 2018577
- J Korean Neurosurg Soc.
- 2002 Jun;31(6):574-584.
OBJECTIVE: This study is designed to evaluate the apoptotic signaling pathway of anticancer agent (cisplatin) on human malignant glioblastoma A172 and T98G cells, bearing wild type p53 and mutated p53,... -
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- Methanol Extracts of Codium fragile Induces Apoptosis through G1/S Cell Cycle Arrest in FaDu Human Hypopharynx Squamous Carcinoma Cells
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Lee SA, Park BR, Moon SM, Kim DK, Kim CS
- KMID: 2437356
- Int J Oral Biol.
- 2018 Jun;43(2):61-68.
- doi: 10.11620/IJOB.2018.43.2.061
Codium fragile (Suringar) Hariot is an edible green seaweed that belong to the Codiaceae family and has been used in Oriental medicine for the treatment of enterobiasis, dropsy, and dysuria.... -
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- The Role of Poly(ADP-ribose) Polymerase-1 in Ventilator-Induced Lung Injury
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Kim JH, Yoon DW, Hur GY, Jung KH, Lee SY, Lee SY, Shin C, Shim JJ, In KH, Yoo SH, Kang KH
- KMID: 1719370
- Tuberc Respir Dis.
- 2006 Apr;60(4):451-463.
- doi: 10.4046/trd.2006.60.4.451
BACKGROUND: Reactive oxygen species (ROS) take center stage as executers in ventilator-induced lung injury (VILI). The protein with DNA-damage scanning activity, poly (ADP-ribose) polymerase-1 (PARP1), signals DNA rupture and participates... -
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- Neuroprotective Effect of N-acetylcysteine in an Asphyxial Cardiac Arrest Model of Rats
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Park SH, Choi CR, Oh DR, Choi SM, Kim SK
- KMID: 2331322
- J Korean Soc Emerg Med.
- 2001 Dec;12(4):447-456.
BACKGROUND: A major pathway leading toward neuronal injury following ischemia-reperfusion of the brain involves elevation of extracellular glutamate and activation of glutamate receptors, with a subsequent increase in intracellular calcium,... -
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- Cadmium-induced Apoptosis in HL-60 Cells Via Signal Transduction
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Kim NS, Oh GJ, Cho KH, Hyun MS, Kim YC, Sung TH, Youm JH, Kwon KS
- KMID: 2028171
- Korean J Occup Environ Med.
- 2002 Mar;14(1):1-12.
OBJECTIVES: Apoptosis is a process of active cell death, distinct from necrosis and characterized by specific morphological and biochemical features. Apoptosis induced by metals and metal-related deleterious conditions has only... -
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