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Glutathione Reductase and Thioredoxin Reductase: Novel Antioxidant Enzymes from Plasmodium berghei

Kapoor G, Banyal HS

Malaria parasites adapt to the oxidative stress during their erythrocytic stages with the help of vital thioredoxin redox system and glutathione redox system. Glutathione reductase and thioredoxin reductase are important...
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Previous Infection with Plasmodium berghei Confers Resistance to Toxoplasma gondii Infection in Mice

Lee DH, Chu KB, Kang HJ, Lee SH, Quan FS

Both Plasmodium spp. and Toxoplasma gondii are important apicomplexan parasites, which infect humans worldwide. Genetic analyses have revealed that 33% of amino acid sequences of inner membrane complex from the...
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Expressed Sequence Tag Analysis of the Erythrocytic Stage of Plasmodium berghei

Seok JW, Lee YS, Moon EK, Lee JY, Jha BK, Kong HH, Chung DI, Hong Y

Rodent malaria parasites, such as Plasmodium berghei, are practical and useful model organisms for human malaria research because of their analogies to the human malaria in terms of structure, physiology,...
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Characterization of Plasmodium berghei Homologues of T-cell Immunomodulatory Protein as a New Potential Candidate for Protecting against Experimental Cerebral Malaria

Cui A, Li Y, Zhou X, Wang L, Luo E

The pathogenesis of cerebral malaria is biologically complex and involves multi-factorial mechanisms such as microvascular congestion, immunopathology by the pro-inflammatory cytokine and endothelial dysfunction. Recent data have suggested that a...
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Glutamate dehydrogenase antigen detection in Plasmodium falciparum infections

Dominiguez Nd, Rodriguez-Acosta A

The usefulness of malaria diagnosis by Plasmodium falciparum-GDH (NADP+), obtained by affinity chromatography, is demonstrated in ELISA assays, testing IgG antibodies against GDH (NADP+) from patients with acute malaria, who...
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Age-Related CD4+CD25+Foxp3+ Regulatory T-Cell Responses During Plasmodium berghei ANKA Infection in Mice Susceptible or Resistant to Cerebral Malaria

Shan Y, Liu J, Pan YY, Jiang YJ, Shang H, Cao YM

Different functions have been attributed to CD4+CD25+Foxp3+ regulatory T-cells (Tregs) during malaria infection. Herein, we describe the disparity in Treg response and pro- and anti-inflammatory cytokines during infection with Plasmodium...
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Induction of Angiogenesis by Malarial Infection through Hypoxia Dependent Manner

Park MK, Ko EJ, Jeon KY, Kim H, Jo JO, Baek KW, Kang YJ, Choi YH, Hong Y, Ock MS, Cha HJ

Malarial infection induces tissue hypoxia in the host through destruction of red blood cells. Tissue hypoxia in malarial infection may increase the activity of HIF1α through an intracellular oxygen-sensing pathway....
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Low Fetal Weight is Directly Caused by Sequestration of Parasites and Indirectly by IL-17 and IL-10 Imbalance in the Placenta of Pregnant Mice with Malaria

Fitri LE, Sardjono T, Rahmah Z, Siswanto B, Handono K, Dachlan YP

The sequestration of infected erythrocytes in the placenta can activate the syncytiotrophoblast to release cytokines that affect the micro-environment and influence the delivery of nutrients and oxygen to fetus. The...
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