- Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome
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Kim B, Feldman EL
- KMID: 2155414
- Exp Mol Med.
- 2015 Mar;47(3):e149.
- doi: 10.1038/emm.2015.3
Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that includes obesity, diabetes, and dyslipidemia. Accumulating evidence implies that MetS contributes to the development and progression of Alzheimer's disease... -
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- Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
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Ciechanover A, Kwon YT
- KMID: 2155412
- Exp Mol Med.
- 2015 Mar;47(3):e147.
- doi: 10.1038/emm.2014.117
Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the... -
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- Effects of oncostatin M on hormone release of rat pituitary cells in primary culture
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Kim DS, Choi HS, Park YS, Kim TW
- KMID: 1128632
- J Korean Med Sci.
- 2000 Jun;15(3):323-326.
- doi: 10.3346/jkms.2000.15.3.323
It has become increasingly clear that cytokines play an important role in modulating neuroendocrine regulation, especially in the secretion of corticotropin (ACTH) in the pituitary. Oncostatin M (OSM), a cytokine... -
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- Lysophosphatidylglycerol inhibits formyl peptide receptor like-1-stimulated chemotactic migration and IL-1beta production from human phagocytes
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Shim JW, Jo SH, Kim SD, Lee HY, Yun J, Bae YS
- KMID: 1119324
- Exp Mol Med.
- 2009 Aug;41(8):584-591.
- doi: 10.3858/emm.2009.41.8.064
In this study, we observed that lysophosphatidylglycerol (LPG) completely inhibited a formyl peptide receptor like-1 (FPRL1) agonist (MMK-1)-stimulated chemotactic migration in human phagocytes, such as neutrophils and monocytes. LPG also... -
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- Bone Mineral Density, Biochemical Bone Turnover Markers and Factors associated with Bone Health in Young Korean Women
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Park YJ, Lee SJ, Shin NM, Shin H, Kim YK, Cho Y, Jeon S, Cho I
- KMID: 2129540
- J Korean Acad Nurs.
- 2014 Oct;44(5):504-514.
- doi: 10.4040/jkan.2014.44.5.504
PURPOSE: This study was done to assess the bone mineral density (BMD), biochemical bone turnover markers (BTMs), and factors associated with bone health in young Korean women. METHODS: Participants were 1,298... -
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- Increased expression of the receptor for advanced glycation end products in neurons and astrocytes in a triple transgenic mouse model of Alzheimer's disease
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Choi BR, Cho WH, Kim J, Lee HJ, Chung C, Jeon WK, Han JS
- KMID: 2155340
- Exp Mol Med.
- 2014 Feb;46(2):e75.
- doi: 10.1038/emm.2013.147
The receptor for advanced glycation end products (RAGE) has been reported to have a pivotal role in the pathogenesis of Alzheimer's disease (AD). This study investigated RAGE levels in the... -
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- Human hepatocellular carcinoma cells resist to TRAIL-induced apoptosis, and the resistance is abolished by cisplatin
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Shin EC, Seong YR, Kim CH, Kim H, Ahn YS, Kim K, Kim SJ, Hong SS, Park JH
- KMID: 1081460
- Exp Mol Med.
- 2002 May;34(2):114-122.
TNF-related apoptosis-inducing ligand (TRAIL), a member of the TNF family, selectively induce apoptosis in various transformed cell lines but not in almost-normal tissues. It is regulated by 2 death receptors,... -
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