- Protection Against Electroshock- and Pentylenetetrazol-induced Seizures by the Water Extract of Rehmannia glutinous can be Mediated through GABA Receptor-chloride Channel Complexes
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Kim M, Kim HJ, Kim SM, De la Peña JB, Dela Peña IJ, Botanas CJ, Woo T, Lee YS, Ryu JH, Cheong JH
- KMID: 2376498
- Nat Prod Sci.
- 2017 Mar;23(1):40-45.
- doi: 10.20307/nps.2017.23.1.40
Epilepsy is a brain disorder that affects millions of people worldwide. It is characterized by recurrent and unpredictable seizures that are usually controlled with antiepileptic/anticonvulsive drugs. However, most antiepileptic drugs... -
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- Lamotrigine Decreased Hippocampal Damage and Improved Vascular Risk Markers in a Rat Model of Pentylenetetrazole Induced Kindling Seizure
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Haggag BS, Hasanin AH, Raafat MH, Abdel Kawy HS
- KMID: 2285520
- Korean J Physiol Pharmacol.
- 2014 Jun;18(3):269-278.
- doi: 10.4196/kjpp.2014.18.3.269
Various antiepileptic drugs (AEDs) especially enzyme-inducing AEDs might be associated with increased vascular risk, through impairment of the endogenous antioxidative ability which may trigger oxygen-dependent tissue injury. Lamotrigine (LTG) a... -
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- Tamoxifen Mimics the Effects of Endogenous Ovarian Hormones on Repeated Seizures Induced by Pentylenetetrazole in Rats
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Mansouri S, Ataei ML, Hosseini M, Bideskan A
- KMID: 1427109
- Exp Neurobiol.
- 2013 Jun;22(2):116-123.
- doi: 10.5607/en.2013.22.2.116
In the present study, the effects of tamoxifen on pentylenetetrazole (PTZ)-induced repeated seizures and hippocampal neuronal damage in ovariectomized rats were investigated. Thirty seven virgin female Wistar rats were divided... -
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- Neuropharmacological effects of deltamethrin in rats
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Manna S, Bhattacharyya D, Mandal TK, Dey S
- KMID: 1059198
- J Vet Sci.
- 2006 Jun;7(2):133-136.
- doi: 10.4142/jvs.2006.7.2.133
This study examined the effect of deltamethrin on some of the neuropharmacological paradigms in a rat brain such as the motor co-ordination test using a rotarod, the pentobarbitone-induced sleeping time and pentylenetetrazole (PTZ)-induced convulsion... -
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- In Vitro Effect of Carbamazepine, D-(-)-2-Amino-5-Phosphonopentanoic Acid and 6-Cyano-7-Nitroquinoxaline-Dione on Pentylenetetrazole-Induced Epileptiform Activity in Young Rat Visual Cortex
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Choi BJ
- KMID: 1851944
- J Korean Epilepsy Soc.
- 2005 Dec;9(2):137-142.
PURPOSE: Carbamazepine (CBZ) has little untoward effect in behavior, cognition and psychosocial aspects and commonly used in children. But, CBZ can sometimes worsen tonic-clonic seizures. The goal of the present... -
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- The Protective Effect of Chlorpromazine on Pentylenetetrazole Induced Seizure
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Kim EA, Kim DW, Chae SA
- KMID: 2329287
- J Korean Child Neurol Soc.
- 2003 May;11(1):20-23.
PURPOSE: Chlorpromazine(CPZ) is known to inhibit glutamate dehydrogenase(GDH). Reductive amination of alpha-ketoglutarate is catalyzed by GDH and forms glutamate, a major excitatory neurotransmitter. Thus, we hypothesized that CPZ might have... -
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- A Study on the Age-Dependent Antiepileptic Effects of the Ketogenic Diet in the Pentylenetetrazole-Seizure Animal Model
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Kim DW, Chae SA, Park HJ
- KMID: 2007340
- J Korean Child Neurol Soc.
- 2002 May;10(1):29-34.
PURPOSE: The ketogenic diet(KD) has been felt to be clinically more efficacious at younger ages, presumably because of the enhanced ability of the immature brain to extract and utilize ketone... -
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- The Immunohistochemical Expression of Neuronal Nitric Oxide Synthase in Rat Hippocampus after Pentylenetetrazole-Induced Seizures
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Kim DK, Jang TJ
- KMID: 2335547
- J Korean Pediatr Soc.
- 2001 Dec;44(12):1432-1440.
PURPOSE: In order to determine the effect of neuronal nitric oxide synthase(nNOS) in seizure-related neuronal vulnerability of the hippocampus, the expression patterns of nNOS were examined in pentylenetetrazole(PTZ)-induced seizure groups... -
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- Expression Changes of c-Fos Protein of Rat Brain Following Pentylenetetrazol-induced Seizures
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Kim EJ, Yoo KS, Hwang GK
- KMID: 2137161
- J Korean Child Neurol Soc.
- 2001 May;9(1):49-58.
PURPOSE: The expression of c-Fos protein has been shown to be a useful marker for elevated levels of neuronal activity generated in the brain following different stimuli, including seizures. This... -
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- Effects of the Ketogenic Diet on Pentylenetetrazole-Induced Seizure
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Kim DW, Kim HS, Ko TS, Chae SA, Kim KJ, Hwang YS
- KMID: 2137159
- J Korean Child Neurol Soc.
- 2001 May;9(1):37-43.
PURPOSE: Despite decades of clinical experience with the ketogenic diet(KD), its efficacy and mechanisms of action have been examined in few animal studies. The present study was designed to investigate... -
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- Effect of Gabapentin on Incisional Pain in Rat Pretreated with Pentylenetetrazole
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Kim HK, Shin SH, Kwon JY, Shin SU, Kim KH, Chung KS
- KMID: 2298976
- Korean J Anesthesiol.
- 2001 Jan;40(1):89-93.
- doi: 10.4097/kjae.2001.40.1.89
BACKGROUND: Tissue injury by surgical manipulation or trauma may cause pain hypersensitivity secondary to central sensitization. The aim of this study was to evaluate the postoperative effect of gabapentin... -
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- The Role of Nitric Oxide in Seizures Induced by Pentylenetetrazole
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Kim JH, Kim KK
- KMID: 1967594
- J Korean Pediatr Soc.
- 2000 Oct;43(10):1356-1363.
PURPOSE: Nitric oxide(NO) is a highly reactive messenger molecule that is synthesized by nitric oxide synthase(NOS) in a number of tissues including the brain. Our aim was to examine the possible role... -
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- The Role of the Glutamate Receptor in the Transient Focal Cerebral Ischemia in Rats
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Chae CH, Kim HK, Kim KH, Baik SW, Kim IS
- KMID: 2155260
- Korean J Anesthesiol.
- 2000 Jun;38(6):1062-1067.
- doi: 10.4097/kjae.2000.38.6.1062
BACKGROUND: To investigate the role of glutamate in the transient focal cerebral ischemia, a reversible middle cerebral artery occlusion model was induced in 25 male Sprague-Dawley rats. METHODS: Triphenyltetrazolium chloride (TTC)... -
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- Effect of Prostaglandin Synthetase Inhibitor Pretreatment on Pentylenetetrazol-induced Seizures
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Choi BJ, Kim YI, Whang KT
- KMID: 1961845
- J Korean Child Neurol Soc.
- 1998 Oct;6(1):47-54.
PURPOSE: Nonsteroidal anti-inflammatory drugs inhibit the synthesis of prostaglandin(PG) through inhibition of the enzyme, cyclooxygenase. Some of the arachidonic acid metabolites may influence the spread of electrocortical activity, and delay... -
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- Changes of Prostaglandin E-2 Levels in Cerebrospinal Fluid in Children with Febrile Convulsion
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Choi BJ, Whang KT
- KMID: 2177121
- J Korean Child Neurol Soc.
- 1998 May;5(2):235-241.
PURPOSE: Prostaglandins(PGs) are known to produce a remarkably broad spectrum of effects that embraces practically every biological function, and has a particular physiological role in the central nervous system. Significant... -
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- Expression of c-myc mRNA in the Hippocampus of Pentylenetetrazol Kindling Rat
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Lee JC, Son EI, Kim IH, Lee SD
- KMID: 2018959
- J Korean Neurosurg Soc.
- 1996 Nov;25(11):2173-2181.
Kindling development is a good animal model of epilepsy and neural plasticity. It is induced by repeated subconvulsive electrical or chemical stimulations. This leads to progressive and permanent amplification of... -
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- Expression of c-fos mRNA in the Hippocampus of Pentylenetetrazol Kindling Rat
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Kim KS, Yoo KM, Suh SI, Yi SD
- KMID: 2066047
- J Korean Neurol Assoc.
- 1996 Mar;14(1):89-101.
Kindling, induced by repeated subconvulsive electrical or chemical stimulations, leads to progressive and permanent amplification of seizure activity, resulting in permanent brain changes. It is a good animal model of... -
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- Mossy Fiber Synaptic Reorganization of Dentate Gyrus by Pentylenetetrazol Kindling Rats
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Yi SD, Lee TH, Park YC
- KMID: 2342473
- J Korean Neurol Assoc.
- 1995 Jun;13(2):239-248.
Recent studies have revealed that mossy fiber(MF) axons of dentate granule cells undergo synaptic reorganization in both electrical kindling models of temporal lobe epilepsy (TLE) and human TLE. This synaptic... -
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- Development and Persistence of Kindling Phenomenon after Injections of Pentylenetetrazol in Rats
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Lee SH, Yi SD, Park YC
- KMID: 2342430
- J Korean Neurol Assoc.
- 1994 Sep;12(3):375-381.
The development of pentylenetetrazol (PTZ) kindling has been controversial, authors confirmed the development of kindling phenomenon in experimental rats following every second or third day intraperitoneal administration of PTZ(20-25mg/kg) to... -
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- A Study of the Mechanism on Hibernation
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Oh YK, Kang HS
- KMID: 687769
- Yonsei Med J.
- 1979 Jun;20(1):17-32.
- doi: 10.3349/ymj.1979.20.1.17
The present study was performed in order to test the effects of diphenylhydantoin (DPH) and two central nervous system (CNS) stimulants, intermittent light stimulation(ILS) and pentylenetetrazol (Metrazol) on body temperature... -
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