J Korean Neurol Assoc.  1994 Sep;12(3):375-381.

Development and Persistence of Kindling Phenomenon after Injections of Pentylenetetrazol in Rats

• Lee SH
• Yi SD
• Park YC

Abstract

The development of pentylenetetrazol (PTZ) kindling has been controversial, authors confirmed the development of kindling phenomenon in experimental rats following every second or third day intraperitoneal administration of PTZ(20-25mg/kg) to experimental rats and same amount of saline to control rats. The developmental stage of motor seizure could be categorized into five stages (stage I; clonic seizure of face and neck, stage II; clonic seizure of face, neck and forelimbs, stage III; clonic seizure of forelimbs and body with brief rearing, stage IV; falling and generalized clonic seizure, stage V; falling and generalized tonic-clonic seizure with tonic extension of hindlimbs). Linear regression analysis showed that the stages of motor seizure were increased with the number of PTZ injections (Y=0.1361X + 0.1943, p < 0.05). The persistence of kindling state was also observed after a 5-months pause of PTZ injection. This study suggested that PTZ kindling model in rats could be a good animal model of generalized epilepsy.

MeSH Terms

Animals
Epilepsy, Generalized
Forelimb
Linear Models
Models, Animal
Neck
Pentylenetetrazole*
Rats*
Seizures
Pentylenetetrazole