- Transient forebrain ischemia induces impairment in cognitive performance prior to extensive neuronal cell death in Mongolian gerbil (Meriones unguiculatus)
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Kondo T, Yoshida S, Nagai H, Takeshita , Mino M, Morioka H, Nakajima T, Kusakabe K, Okada T
- KMID: 2417565
- J Vet Sci.
- 2018 Jul;19(4):505-511.
- doi: 10.4142/jvs.2018.19.4.505
In Mongolian gerbils, bilateral common carotid artery occlusion (BCCAO) for several minutes induces ischemia, due to an incomplete circle of Willis, resulting in delayed neuronal cell death in the Cornet... -
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- Landscape of inflammatory bowel disease in Singapore
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Low D, Swarup N, Okada T, Mizoguchi E
- KMID: 2531982
- Intest Res.
- 2022 Jul;20(3):291-296.
- doi: 10.5217/ir.2021.00089
Inflammatory bowel disease (IBD), primarily Crohn’s disease and ulcerative colitis, had been widely recognized to affect the Western population. However, the notable rise in prevalence of IBD in Asia, including... -
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- Does caffeine have a double-edged sword role in inflammation and carcinogenesis in the colon?
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Mizoguchi E, Sadanaga T, Okada T, Minagawa T, Akiba J
- KMID: 2544754
- Intest Res.
- 2023 Jul;21(3):306-317.
- doi: 10.5217/ir.2022.00118
Caffeine (1,3,7-trimethylxanthine, also abbreviated to CAF) is a natural chemical with stimulant effects and is commonly included in many drinks and foods, including coffee, tea, cola, energy drinks, cocoa, chocolates,... -
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- Recent updates on the basic mechanisms and pathogenesis of inflammatory bowel diseases in experimental animal models
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Mizoguchi , Low D, Ezaki Y, Okada T
- KMID: 2501381
- Intest Res.
- 2020 Apr;18(2):151-167.
- doi: 10.5217/ir.2019.09154
The specific pathogenesis underlining inflammatory bowel disease (IBD) is very complicated, and it is further more difficult to clearly explain the pathophysiology of 2 major forms of IBD, Crohn’s disease... -
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- Extremely-slow, half-number shockwave lithotripsy for asymptomatic renal stones <20 mm
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Ito K, Takahashi T, Kanno T, Okada T, Higashi Y, Yamada H
- KMID: 2509854
- Investig Clin Urol.
- 2021 Jan;62(1):72-78.
- doi: 10.4111/icu.20200285
Purpose: To compare the treatment success rate and safety of reduced (30 shocks/min, 1,200 shocks/session) versus standard (60 shocks/min, 2,400 shocks/session) extracorporeal shockwave lithotripsy for the management of renal stones. Materials... -
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- Promoter effects of adeno-associated viral vector for transgene expression in the cochlea in vivo
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Liu Y, Okada T, Nomoto T, Ke X, Kume A, Ozawa K, Xiao S
- KMID: 1094657
- Exp Mol Med.
- 2007 Apr;39(2):170-175.
The aims of this study were to evaluate the expression of enhanced green fluorescent protein (EGFP) driven by 6 different promoters, including cytomegalovirus IE enhancer and chicken beta-actin promoter (CAG),... -
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- Predictive Value of Localized Stenosis of the Main Pancreatic Duct for Early Detection of Pancreatic Cancer
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Kanno Y, Koshita S, Ogawa T, Kusunose H, Masu K, Sakai T, Yonamine K, Kawakami Y, Fujii Y, Miyamoto K, Murabayashi T, Kozakai F, Horaguchi , Noda Y, Oikawa M, Okada T, Ito K
- KMID: 2465802
- Clin Endosc.
- 2019 Nov;52(6):588-597.
- doi: 10.5946/ce.2019.018
BACKGROUND/AIMS: In this study, we aimed to evaluate the predictive value of localized stenosis of the main pancreatic duct (MPD) for early detection of pancreatic cancer. METHODS: Among 689 patients who... -
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- Angiopoietin-Like Protein 2 Induces Synovial Inflammation in the Facet Joint Leading to Degenerative Changes via Interleukin-6 Secretion
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Sugimoto K, Nakamura T, Tokunaga T, Uehara Y, Okada T, Taniwaki T, Fujimoto T, Oike Y, Nakamura E
- KMID: 2449790
- Asian Spine J.
- 2019 Jun;13(3):368-376.
- doi: 10.31616/asj.2018.0178
STUDY DESIGN: Experimental human study. PURPOSE: To determine whether angiopoietin-like protein 2 (ANGPTL2) is highly expressed in the hyperplastic facet joint (FJ) synovium and whether it activates interleukin-6 (IL-6) secretion in... -
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