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Physiology of Neuromuscular Junction

Suh JH

No abstract available.
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Updated review of resistance to neuromuscular blocking agents

Jung KT, An TH

Since neuromuscular blocking agents (NMBAs) were introduced to the surgical field, they have become almost mandatory for the induction and maintenance of anesthesia. However, resistance to NMBAs can develop in...
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Anesthetic Management for 12 Patients with Myasthenia Gravis

Kim SJ, Seung IS, Lee C, Kim KH, Lee DH, Kim KS, Suh JK, Yoo HK, Chon SU, Shim JC

Serious complications and death may occur in patients with neuromuscular disorders after administration of muscle relaxants that include prolonged paralysis, hyperkalemia, muscle rigidy and malignant hyperthermia. Myasthenia gravis, neuromuscular junctional...
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Ultrastructure of neuromuscular junction in vacor-induced diabetic rats

Ahn JS, Lee TH, Lee MC

  • KMID: 759055
  • Korean J Intern Med.
  • 1998 Feb;13(1):47-50.
OBJECTIVES: Rodenticide Vacor causes a severe peripheral neuropathy in humans. Electrophysiologic studies on a peripheral motor nerve-skeletal system of Vacor-treated rat showed decreased amplitude of muscle action potential without conduction...
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Comparison of Pharmacokinetic Affinity of Various Non-depolarizing Neuromuscular Blocking Agents in the Isolated Foream

Lee SK, Jeon YS, Ahn JS, Hwang KH, Park W, Kim SY

It is well known that the plasma concentration is important in determining the rate of recovery from neuromuscular block. However, nondepolarizing neuromuscular blockade are retained at the neuromuscular junction and...
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A Case of Myasthenia Gravis in Pregnancy

Kang JH, Han K, Song JH, Choi JS

  • KMID: 2272055
  • Korean J Obstet Gynecol.
  • 2003 May;46(5):1064-1068.
Myasthenia gravis is a autoimmune neuromuscular disorder characterized by weakness and fatigability of skeletal muscles. The underlying defect is a decrease in the number of available acetylcholine receptors at neuromuscular...
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Factors that affect the onset of action of non-depolarizing neuromuscular blocking agents

Kim YB, Sung TY, Yang HS

Neuromuscular blockade plays an important role in the safe management of patient airways, surgical field improvement, and respiratory care. Rapid-sequence induction of anesthesia is indispensable to emergency surgery and obstetric...
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Sarcopenia: Neurological Point of View

Kwon YN, Yoon SS

Sarcopenia is an age-related geriatric syndrome which is characterized by the gradual loss of muscle mass, muscle strength, and muscle quality. There are a lot of neurologic insults on sarcopenia...
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Neuromuscular Blocking Action of Neostigmine Methylsulfate

Lee SD, Hwang KH, Lee JS, Kang KS, Park W, Kim SY

BACKGROUND: Although the neuromuscular blocking properties of neostigmine have been known for many years, few assessment of this effect has been described in man. The aim of this study is...
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The Effects of Atropine and Glycopyrrolate on the Recovery from Mivacurium: Induced Neuromuscular Blockade in the Rabbit

Kwon OK, Kim CS

BACKGROUND: Antimuscarinic agents are used to block undesirable muscarinic effects of `anticholinesterase given to reverse the residual neuromuscular blockade produced by muscle relaxants. However, besides antimuscarinic effects, atropine was known...
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Successful anesthetic management of two myasthenic patients using total intravenous anesthesia without muscle relaxants: A report of two cases

Park JT, Kim SG, Lee YB

  • KMID: 2263244
  • Anesth Pain Med.
  • 2011 Oct;6(4):385-388.
Myasthenia gravis (MG) is an autoimmune-mediated disease characterized by weakness and fatigability due to dysfunction of the neuromuscular junction from antibodies directed against the acetylcholine receptor (AchR). The main considerations...
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Myasthenia in Acquired Neuromyotonia

Byun JI, Moon HJ, Hong YH

  • KMID: 2400179
  • J Clin Neurol.
  • 2014 Jan;10(1):69-71.
BACKGROUND: Acquired neuromyotonia (NMT) forms part of the spectrum of acquired peripheral nerve hyperexcitability syndrome, and is thought to be caused by antibodies to voltage-gated potassium channels (VGKC). Exertional weakness...
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Repetitive Nerve Stimulation Test in Myotonic Patients

Park JH, Sunwoo IN, Moon JS, Lee SA, Park YG, Kim KW

  • KMID: 1957302
  • J Korean Neurol Assoc.
  • 1994 Dec;12(4):702-708.
In 17 myotonic cases (16 of myotonic muscular dystrophy and 1 of congenital myotonia), 13 cases showed significant decremental responses on RNS study. The decremental responses had the tendency of...
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Immunohistochemical Localization of NCAM at Neuromuscular Contacts in Rat Muscle-Rat Nerve Cocultures

Uhm CS, Suh YS

  • KMID: 2040097
  • Korean J Anat.
  • 1999 Aug;32(4):527-533.
Neuromuscular junction formation is one of the hot research area for understanding synapse formation, and the contact and adhesion between muscle and neurons during this procedure is regarded as one...
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The Effect of Intravenous Lidocaine Infusion on Succinylcholine - or Vecuronium - induced Neuromuscular Block in the Cat

Shin YS, Kim MH, Lee KY, Moon BG, Kwak YL, Kim JR, Park KW

The effect of lidocaine on the neuromuscular junction and the interaction between lidocaine and the muscle relaxant, succinylcholine(SCC) or vecuronium(VEC), were investigated in 12 cats of either sex using the...
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Neuromuscular Blocking Properties of Dantrolene at the Neuromuscular Junction and Its Recovery with Various Antagonists

Kim SY, Lee JS

BACKGROUND: Dantrolene produces skeletal muscle relaxation by a direct action on excitation-contraction coupling, presumably by decreasing the amount of calcium released from the sarcoplasmic reticulum. The mechanism underlying this...
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Myasthenia Gravis Presenting Hyperacusia and Ptosis

Kim SH, Choi SY, Yoon SJ, Chun JU

  • KMID: 1454831
  • J Korean Neurol Assoc.
  • 2010 Feb;28(1):53-55.
Myasthenia gravis (MG), which is the most common autoimmune neuromuscular junction disorder, is characterized by weakness of musdes and increased fatigability after repetitive use, and recovery after rest. The diagnosis...
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A Case of Myasthenia Gravis Associated with Extrathymic Malignant lymphoma

Kim SY, Lee MA, Woo IS, Kang JH, Hong YS, Lee KS

  • KMID: 2252412
  • Korean J Hematol.
  • 2003 Aug;38(3):210-212.
Myasthenia gravis is an autoimmune disease involving neuromuscular junction. It can be associated with thymic hyperplasia, thymoma and various tumors involving thymus, but extrathymic malignant lymphoma associated with myasthenia gravis...
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Application of Botulinum Toxin Injection in Plastic Surgery

Joh SH

  • KMID: 2098264
  • J Korean Soc Plast Reconstr Surg.
  • 2003 Mar;30(2):164-170.
Botulinum toxin type A is a neurotoxin produced by clostridium botulinum that blocks the presynaptic release of acetylcholine at the neuromuscular junction. This blockade of the neuromuscular junction is definitive,...
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Respiratory Depression after Anesthesia in an Eclamptic Patient Treated with Magnesium Sulfate

Han YJ, Ki SJ, Song HS

  • KMID: 2357558
  • Korean J Anesthesiol.
  • 1979 Sep;12(3):291-295.
Prolonged respiratory depression was noticed after termination of anesthesia. in a patient with severe. eclampsia who had been treated with magnesium sulfate. 1) Magnesium sulfate is an anticonvulsant the most...
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