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A Case of Incidental Retroperitoneal Ganglioneuroma

Song WY, Lee MW, Han IS, Park YJ, Han SY, Baek DH, Lee BE, Kim GH

Ganglioneuroma is a rare benign tumor originating from the neural crest cells. It occurs most commonly in the retroperitoneum and posterior mediastinum and is often found in the neck or...
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Neuropeptides Profile and Increased Innervation in Becker's Nevus

Kim JS, Park MJ, Kang HY, Hong SP, Park BC, Kim MH

BACKGROUND: Melanocytes are derived from neural crest, and various pigmentary disorders may accompany abnormalities in nerve system or develop following dermatome, suggesting that melanocyte and pigmentation may be closely related...
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Embryological Consideration of Dural AVFs in Relation to the Neural Crest and the Mesoderm

Tanaka M

Intracranial and spinal dural arteriovenous fistulas (DAVFs) are vascular pathologies of the dural membrane with arteriovenous shunts. They are abnormal communications between arteries and veins or dural venous sinuses that...
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Immunohistochemistry: sole tool in diagnosing a rare case of primary vaginal amelanotic melanoma

Garg R, Gupta N

We report a rare case of vaginal amelanotic melanoma. Malignant melanomas are cutaneous and extracutaneous tumors that arise from embryological remnants of neural crest cells/melanocytes. Amelanotic melanomas at such rare...
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Prenatally detected thoracic neuroblastoma

Park Y, Lee HJ, Jung YJ, Lee JH, Kwon JY, Kim YH

Neuroblastoma is the most common pediatric extracranial solid tumor derived from primitive neural crest cells of the sympathetic nervous system. Although one-fifths of all neuroblastomas occurs within the thorax, thoracic...
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In Vitro Osteogenic Differentiation of Human Mesenchymal Stem Cells from Jawbone Compared with Dental Tissue

Pettersson LF, Kingham PJ, Wiberg M, Kelk P

Autologous bone transplantation is the current gold standard for reconstruction of jawbone defects. Bone regeneration usingmesenchymal stem cells (MSC) is an interesting alternative to improve the current techniques,which necessitate a...
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Clinical Features and Treatment Outcome of Soft Tissue Clear Cell Sarcoma

An HY, Baek SM, Kim BK, Choi JY, Hong KT, Hong CR, Choi TH, Kim HS, Kim TM, Kang HJ, Shin HY

BACKGROUND: Soft tissue clear cell sarcoma is a rare tumor which originates from neural crest cells. Due to its rarity and lack of established treatment, the prognosis of clear cell...
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Malignant Paraganglioma in the Common Hepatic Duct

Lee HS, Jeong CU, Lee ES, Kwon YJ, Kim YS, Kim JD, Lee YJ

Paragangliomas are rare extra-adrenal neoplasms of neural crest origin. The neoplasms may develop at various sites, but most are located in the para-aortic space along the sympathetic chain. A paraganglioma...
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Extra-Adrenal Malignant Paragangliomas Presenting as Mesenteric and Pararectal Masses: A Case Report

Lee S, Lee J, Kim BH, Kim KA, Park CM

Extra-adrenal paraganglioma is a rare tumor arising from the neural crest cells. Most tumors that develop in the abdomen arise from paraganglia along the paravertebral and para-aortic areas, in particular...
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Condition medium of cerebrospinal fluid and retinoic acid induces the transdifferentiation of human dental pulp stem cells into neuroglia and neural like cells

Haratizadeh S, Nazm Bojnordi M, Darabi S, Karimi N, Naghikhani M, Ghasemi Hamidabadi H, Seifi M

Cerebrospinal fluid (CSF) contains several molecules which are essential for neurogenesis. Human dental pulp stem cells (hDPSCs) are putatively neural crest cell-derived that can differentiate into neurons and glial cells...
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Giant Ganglioneuroma of Thoracic Spine: A Case Report and Review of Literature

Huang Y, Liu L, Li Q, Zhang S

Ganglioneuroma (GN) is a rare benign tumor of neural crest origin usually found in the abdomen, but may occasionally present at uncommon sites including the cervical, lumbar, or sacral spine....
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Understanding of Human Embryo Development for Teratogen Counselling

Chun Y, Lee H

Human embryology is the study of development from a single cell to a baby in 9 months. Implantation occurs at the end of the first week of development. The second...
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Sox9 regulates development of neural crest and otic placode in a time- and dose-dependent fashion

Park BY

Neural crest and placodes share a number of important features, pointing to a possible common evolutionary origin. They both arise from the neural plate border, which is the boundary between...
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Temporal and Spatial Expression Patterns of miR-302 and miR-367 During Early Embryonic Chick Development

Jeong HS, Lee JM, Suresh B, Cho KW, Jung HS, Kim KS

The microRNAs (miRNAs) are small, non-coding RNAs that modulate protein expression by interfering with target mRNA translation or stability. miRNAs play crucial roles in various functions such as cellular, developmental,...
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Ventrally Located Cervical Dumbbell Ganglioneuroma Producing Spinal Cord Compression

Son DW, Song GS, Kim YH, Lee SW

Ganglioneuroma is an uncommon benign tumor and arise from neural crest cells or sympathetic and peripheral nerves. A 13-year-old boy was referred to our institute and presented with three-day history...
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Heterogeneity of glandular cells in the human salivary glands: an immunohistochemical study using elderly adult and fetal specimens

Katori Y, Hayashi S, Takanashi , Kim JH, Abe S, Murakami G, Kawase T

Using immunohistochemical staining for alpha-smooth muscle actin (alpha-SMA), glial fibrillary acidic protein (GFAP), S100 protein (S100), p63, cytokeratin 14 (CK14), and cytokeratin 19 (CK19), we studied acinar and myoepithelial cells...
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Smad4 Mediated TGF-beta/BMP Signaling in Tooth Formation Using Smad4 Conditional Knockout Mouse

Yoon CY, Baek JA, Cho ES, Ko SO

  • KMID: 2058698
  • J Korean Assoc Maxillofac Plast Reconstr Surg.
  • 2013 Mar;35(2):73-81.
PURPOSE: Smad4 is a central mediator for transforming growth factor-beta/bone morphogenetic protein (TGF-beta/BMP) signals, which are involved in regulating cranial neural crest cell formation, migration, proliferation, and fate determination. Accumulated...
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Ganglioneuroma of Lumbar Nerve Root: A Case Report

Jeong M, Lee S, Joo KB, Jang KS, Bae J

Ganglioneuroma is a rare, benign, slow-growing, well-differentiated tumor consisting of ganglion cells and Schwann cells. Ganglioneuromas originate from neural crest cells and can affect any part of the sympathetic tissue...
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Modification of Pluripotency and Neural Crest-Related Genes' expression in Murine Skin-Derived Precursor Cells by Leukemia Inhibitory Factor (LIF)

Park SK, Roh S

  • KMID: 1431131
  • Int J Oral Biol.
  • 2012 Dec;37(4):175-180.
Skin-derived precursor cells (SKPs) are multipotent, sphere-forming and embryonic neural crest-related precursor cells that can be isolated from dermis. It is known that the properties of porcine SKPs can be...
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Ga-68 Somatostatin Receptor PET/CT in von Hippel-Lindau Disease

Oh JR, Kulkarni H, Carreras C, Schalch G, Min JJ, Baum RP

  • KMID: 2052010
  • Nucl Med Mol Imaging.
  • 2012 Jun;46(2):129-133.
Von Hippel-Lindau (VHL) disease is a dominantly inherited familial cancer syndrome with a variety of benign and malignant tumors such as retinal and central nervous system hemangioblastomas, endolymphatic sac tumors,...
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