- Field Cancerization in Sporadic Colon Cancer
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Park SK, Song CS, Yang HJ, Jung YS, Choi KY, Koo DH, Kim KE, Jeong KU, Kim HO, Kim H, Chun HK, Park DI
- KMID: 2412075
- Gut Liver.
- 2016 Sep;10(5):773-780.
- doi: 10.5009/gnl15334
BACKGROUND/AIMS: Aberrant DNA methylation has a specific role in field cancerization. Certain molecular markers, including secreted frizzled-related protein 2 (SFRP2), tissue factor pathway inhibitor 2 (TFPI2), N-Myc downstream-regulated gene 4... -
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- Inhibition of BETA2/NeuroD by Id2
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Ghil SH, Jeon YJ, Suh-Kim H
- KMID: 755209
- Exp Mol Med.
- 2002 Nov;34(5):367-373.
Id (Inhibitor of Differentiation) proteins belong to a family of transcriptional modulators that are characterized by a helix loop helix (HLH) region but lack the basic amino acid domain. Id... -
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- Molecular cloning of clathrin assembly protein gene (rCALM) and its differential expression to AP180 in rat brain
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Kim HL, Lee SC
- KMID: 1029926
- Exp Mol Med.
- 1999 Dec;31(4):191-196.
Binding of clathrin assembly protein to clathrin triskelia induces their assembly into clathrin-coated vesicle (CCV) in neurons. The clathrin assembly protein gene (rCALM) was cloned from rat brain... -
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- Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
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Ciechanover A, Kwon YT
- KMID: 2155412
- Exp Mol Med.
- 2015 Mar;47(3):e147.
- doi: 10.1038/emm.2014.117
Mammalian cells remove misfolded proteins using various proteolytic systems, including the ubiquitin (Ub)-proteasome system (UPS), chaperone mediated autophagy (CMA) and macroautophagy. The majority of misfolded proteins are degraded by the... -
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- Multiple Roles of BRIT1/MCPH1 in DNA Damage Response, DNA Repair, and Cancer Suppression
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Lin SY, Liang Y, Li K
- KMID: 1074978
- Yonsei Med J.
- 2010 May;51(3):295-301.
- doi: 10.3349/ymj.2010.51.3.295
Mammalian cells are frequently at risk of DNA damage from both endogenous and exogenous sources. Accordingly, cells have evolved the DNA damage response (DDR) pathways to monitor and assure the... -
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- Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells
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Cho YM, Jang YS, Jang YM, Chung SM, Kim HS, Lee JH, Jeong SW, Kim IK, Kim JJ, Kim KS, Kwon OJ
- KMID: 756236
- Exp Mol Med.
- 2009 Jun;41(6):440-452.
- doi: 10.3858/emm.2009.41.6.049
When we treated rat bone marrow stromal cells (rBMSCs) with neuronal differentiation induction media, typical unfolded protein response (UPR) was observed. BIP/GRP78 protein expression was time-dependently increased, and three branches... -
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- Insulin-dependent suppression of cholesterol 7alpha-hydroxlase is a possible link between glucose and cholesterol metabolisms
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Park WH, Pak YK
- KMID: 1123369
- Exp Mol Med.
- 2011 Oct;43(10):571-579.
- doi: 10.3858/emm.2011.43.10.064
Cholesterol 7alpha-hydroxylase (CYP7A1) regulates the balance between cholesterol supply and metabolism by catalyzing the rate-limiting step of bile acid biosynthesis. The transcriptional activity of CYP7A1 is tightly controlled by various... -
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- Shank 2 expression coincides with neuronal differentiation in the developing retina
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Kim JH, Kim JH, Yang E, Park JH, Yu YS, Kim KW
- KMID: 1088598
- Exp Mol Med.
- 2009 Apr;41(4):236-242.
- doi: 10.3858/emm.2009.41.4.026
The retinal activity for vision requires a precise synaptic connectivity. Shank proteins at postsynaptic sites of excitatory synapses play roles in signal transmission into the postsynaptic neuron. However, the correlation... -
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- JNK/stress-activated protein kinase associated protein 1 is required for early development of telencephalic commissures in embryonic brains
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Cho IH, Lee KW, Ha HY, Han PL
- KMID: 1022121
- Exp Mol Med.
- 2011 Aug;43(8):462-470.
- doi: 10.3858/emm.2011.43.8.052
We previously reported that mice lacking JSAP1 (jsap1-/-) were lethal and the brain of jsap1-/- at E18.5 exhibited multiple types of developmental defects, which included impaired axon projection of the... -
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- Identification of two novel frame shift mutations of the NF1 gene in Korean patients with neurofibromatosis type 1
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Park KC, Choi HO, Han WS, Hwang JH, Park KH, Kim KH, Chung JH, Eun HC
- KMID: 965876
- J Korean Med Sci.
- 2000 Oct;15(5):542-544.
- doi: 10.3346/jkms.2000.15.5.542
Neurofibromatos is type 1 (NF1) is one of the most common inherited disorders and is characterized by abnormalities in multiple tissues derived from the neural crest. The NF-1 gene has... -
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- False Homozygosity Results in HLA Genotyping due to Loss of Chromosome 6 in a Patient with Acute Lymphoblastic Leukemia
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Park H, Hyun J, Park SS, Park MH, Song EY
- KMID: 1781698
- Korean J Lab Med.
- 2011 Oct;31(4):302-306.
- doi: 10.3343/kjlm.2011.31.4.302
Loss of heterozygosity (LOH) in chromosome 6p has been reported in a number of tumors and some hematologic malignancies, including ALL. LOH in chromosome 6p, on which the HLA genes... -
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- Heat shock protein 70 alters the endosome-lysosomal localization of huntingtin
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Kang BS, Ahn JY, Kim MK, Kim HJ, Kang L, Lim HC, Park KS, Lee JS, Seo JS, Cha CI, Kim SU, Park YJ, Kim M
- KMID: 1103679
- Exp Mol Med.
- 2007 Feb;39(1):38-46.
Huntington's disease is caused by CAG trinucleotide expansions in the gene encoding huntingtin. N- terminal fragments of huntingtin with polyglutamine produce aggregates in the endosome-lysosomal system, where proteolytic fragments of... -
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- Differential patterns of nestin and glial fibrillary acidic protein expression in mouse hippocampus during postnatal development
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Kim JS, Kim J, Kim Y, Yang M, Jang H, Kang S, Kim JC, Kim SH, Shin T, Moon C
- KMID: 1067330
- J Vet Sci.
- 2011 Mar;12(1):1-6.
- doi: 10.4142/jvs.2011.12.1.1
Intermediate filaments, including nestin and glial fibrillary acidic protein (GFAP), are important for the brain to accommodate neural activities and changes during development. The present study examined the temporal changes... -
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- Deletion of SMN and NAIP genes in Korean patients with spinal muscular atrophy
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Shin S, Park SS, Hwang YS, Lee KW, Chung SG, Lee YJ, Park MH
- KMID: 1731242
- J Korean Med Sci.
- 2000 Feb;15(1):93-98.
- doi: 10.3346/jkms.2000.15.1.93
Childhood-onset proximal spinal muscular atrophies (SMAs) are an autosomal recessive, clinically heterogeneous group of neuronopathies characterized by selective degeneration of anterior horn cells. The causative genes to be reported are... -
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