- p53 Mutations and Microsatellite Instabilities in the Subtype of Intestinal Metaplasia of the Stomach
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Kim SS, Bhang CS, Min KO, Chae HS, Choi SW, Lee CD, Lim KW, Chung IS, Park DH
- KMID: 1109757
- J Korean Med Sci.
- 2002 Aug;17(4):490-496.
- doi: 10.3346/jkms.2002.17.4.490
To investigate the potential implication of the subtype of intestinal metaplasia in the progression to the gastric carcinoma, we analyzed the mutations of the p53 gene and microsatellite instability (MSI)... -
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- DNA Methylation Patterns of Ulcer-Healing Genes Associated with the Normal Gastric Mucosa of Gastric Cancers
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Hong SJ, Oh JH, Jung YC, Kim YH, Kim SJ, Kang SJ, Seo EJ, Choi SW, Kang MI, Rhyu MG
- KMID: 1778036
- J Korean Med Sci.
- 2010 Mar;25(3):405-417.
- doi: 10.3346/jkms.2010.25.3.405
Recent evidence suggests that gastric mucosal injury induces adaptive changes in DNA methylation. In this study, the methylation status of the key tissue-specific genes in normal gastric mucosa of healthy... -
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- Gene expression responses in vivo by human telomerase reverse transcriptase (hTERT)-targeting trans-splicing ribozyme
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Song MS, Jeong JS, Cho KS, Lee SW
- KMID: 1091067
- Exp Mol Med.
- 2007 Dec;39(6):722-732.
A trans-splicing ribozyme which can specifically reprogram human telomerase reverse transcriptase (hTERT) RNA was previously suggested as a useful agent for tumor-targeted gene therapy. In this study, we evaluated in... -
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- ANT2 suppression by shRNA restores miR-636 expression, thereby downregulating Ras and inhibiting tumorigenesis of hepatocellular carcinoma
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Jang JY, Lee YS, Jeon YK, Lee K, Jang JJ, Kim CW
- KMID: 2154222
- Exp Mol Med.
- 2013 Jan;45(1):e3.
MicroRNAs (miRNAs) participate in diverse biological functions and carcinogenesis by inhibiting specific gene expression. We previously reported that suppression of adenine nucleotide translocase 2 (ANT2) by using the short hairpin... -
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- Pathologic findings at risk-reducing salpingo-oophorectomy (RRSO) in germline BRCA mutation carriers with breast cancer: significance of bilateral RRSO at the optimal age in germline BRCA mutation carriers
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Lee YJ, Lee SW, Kim KR, Jung KH, Lee JW, Kim YM
- KMID: 2413850
- J Gynecol Oncol.
- 2017 Jan;28(1):e3.
- doi: 10.3802/jgo.2017.28.e3
OBJECTIVE: Most BRCA1/2 carriers do not undergo risk-reducing salpingo-oophorectomy (RRSO) by the recommended age. This study aimed to find the incidence of precursor lesions and cancer after RRSO. METHODS: We retrospectively... -
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- Identification of a Rare 3 bp BRAF Gene Deletion in a Thyroid Nodule by Mutant Enrichment with 3'-Modified Oligonucleotides Polymerase Chain Reaction
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Jang MA, Lee ST, Oh YL, Kim SW, Chung JH, Ki CS, Kim JW
- KMID: 1381693
- Ann Lab Med.
- 2012 May;32(3):238-241.
- doi: 10.3343/alm.2012.32.3.238
Papillary thyroid carcinoma (PTC) is the most common malignant thyroid tumor, and 36-69% of PTC cases are caused by mutations in the BRAF gene. The substitution of a valine for... -
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- Ectopic Over-expression of Oncogene Pim-2 Induce Malignant Transformation of Nontumorous Human Liver Cell Line L02
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Ren K, Duan W, Shi Y, Li B, Liu Z, Gong J
- KMID: 1792950
- J Korean Med Sci.
- 2010 Jul;25(7):1017-1023.
- doi: 10.3346/jkms.2010.25.7.1017
In order to prove that ectopic over-expression of Pim-2 could induce malignant transformation of human liver cell line L02, three groups of cells were set up including human liver cell... -
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- Gene Therapy for Head and Neck Squamous Cell Carcinoma Using KITENIN (KAI1 COOH-Terminal Interacting Tetraspanin)-Antisense Therapy
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Lee JK, Lee DH, Sun EG, Bae JA, Lim SC, Min JJ, Sung MW, Kim KK
- KMID: 1777018
- Yonsei Med J.
- 2011 May;52(3):463-468.
- doi: 10.3349/ymj.2011.52.3.463
PURPOSE: KAI1 COOH-terminal interacting tetraspanin (KITENIN) has been found to act as a promoter of metastasis in murine models of colon cancer and squamous cell carcinoma (SCC). The suppression of... -
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