- Characterization of Mutator Pathway in Younger-age-onset Colorectal Adenocarcinomas
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Roh SA, Kim HC, Kim JS, Kim JC
- KMID: 2157655
- J Korean Med Sci.
- 2003 Jun;18(3):387-391.
- doi: 10.3346/jkms.2003.18.3.387
The high-frequency microsatellite instability (MSI-H) phenotype, frequently identified in hereditary nonpolyposis colorectal cancer (HNPCC), also accounts for approximately 15% of sporadic colorectal cancers. Microsatellite instability (MSI) occurs from the mutational... -
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- Clinical significance of molecular genetic changes in sporadic invasive pituitary adenomas
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Nam DH, Song SY, Park KS, Kim MH, Suh YL, Lee JI, Kim JS, Hong SC, Shin HJ, Park K, Eoh W, Kim JH
- KMID: 938873
- Exp Mol Med.
- 2001 Sep;33(3):111-116.
Several molecular and genetic changes have been found in pituitary adenomas. We looked for correlations between these changes and the degree of invasiveness of the tumors. The invasiveness of 11... -
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- Characterization of aberrant FHIT transcripts in gastric adenocarcinomas
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Lee SH, Kim CJ, Park HK, Koh JW, Cho MH, Baek MJ, Lee MS
- KMID: 938875
- Exp Mol Med.
- 2001 Sep;33(3):124-130.
Aberrant transcripts of FHIT (fragile histidine triad) have been reported in several types of primary tumors and cell lines, including gastric carcinoma. The role of these aberrant transcripts in tumorigenesis... -
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- Prognostic Significance of Multidrug Resistance Gene 1 (MDR1), Multidrug Resistance-related Protein (MRP) and Lung Resistance Protein (LRP) mRNA Expression in Acute Leukemia
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Huh HJ, Park CJ, Jang S, Seo EJ, Chi HS, Lee JH, Lee KH, Seo JJ, Moon HN, Ghim T
- KMID: 1781831
- J Korean Med Sci.
- 2006 Apr;21(2):253-258.
- doi: 10.3346/jkms.2006.21.2.253
The prognostic significance of multidrug resistance (MDR) gene expression is controversial. We investigated whether multidrug resistance gene 1 (MDR1), multidrug resistance-related protein (MRP) and lung resistance protein (LRP) mRNA expression... -
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- Genetic analysis of ABCG2 and SLC2A9 gene polymorphisms in gouty arthritis in a Korean population
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Kim YS, Kim Y, Park G, Kim SK, Choe JY, Park BL, Kim HS
- KMID: 2381597
- Korean J Intern Med.
- 2015 Nov;30(6):913-920.
- doi: 10.3904/kjim.2015.30.6.913
BACKGROUND/AIMS: Gout is a common inf lammatory arthritis triggered by the crystallization of uric acid in the joints. Serum uric acid levels are highly heritable, suggesting a strong genetic component.... -
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- Prognostic role of genetic biomarkers in clinical progression of prostate cancer
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Alvarez-Cubero MJ, Martinez-Gonzalez LJ, Saiz M, Carmona-Saez P, Alvarez JC, Pascual-Geler M, Lorente JA, Cozar JM
- KMID: 2155430
- Exp Mol Med.
- 2015 Aug;47(8):e176.
- doi: 10.1038/emm.2015.43
The aim of this study was to analyze the use of 12 single-nucleotide polymorphisms in genes ELAC2, RNASEL and MSR1 as biomarkers for prostate cancer (PCa) detection and progression, as... -
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- Genetic Association for P2X7R rs3751142 and CARD8 rs2043211 Polymorphisms for Susceptibility of Gout in Korean Men: Multi-Center Study
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Lee SW, Lee SS, Oh DH, Park DJ, Kim HS, Choi JR, Chae SC, Yun KJ, Chung WT, Choe JY, Kim SK
- KMID: 2468246
- J Korean Med Sci.
- 2016 Oct;31(10):1566-1570.
- doi: 10.3346/jkms.2016.31.10.1566
The aim of this study was to determine the association between P2X7R rs3751142 and CARD8 rs2043211 polymorphisms and gout susceptibility in male Korean subjects. This study enrolled a total of... -
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- Frequent Epigenetic Inactivation of XAF1 by Promotor Hypermethylation in Human Colon Cancers
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Jang JY, Kim HJ, Chi SG, Lee KY, Nam KD, Kim NH, Lee SK, Joo KR, Dong SH, Kim BH, Chang YW, Lee JI, Chang R
- KMID: 772766
- Korean J Gastroenterol.
- 2005 Apr;45(4):285-293.
BACKGROUND/AIMS: X-linked inhibitor of apoptosis (XIAP) is the most potent member of the IAP family that exerts antiapoptotic effects. Recently, XIAP-associated factor 1 (XAF1) and two mitochondrial proteins, Smac/DIABLO... -
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- Expression of Melanoma Antigen-Encoding Genes (MAGE) by Common Primers for MAGE-A1 to -A6 in Colorectal Carcinomas Among Koreans
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Park MS, Park JW, Jeon CH, Lee KD, Chang HK
- KMID: 1109758
- J Korean Med Sci.
- 2002 Aug;17(4):497-501.
- doi: 10.3346/jkms.2002.17.4.497
This study was to investigate Melanoma-antigen gene (MAGE) expression by reverse transcription-nested polymerase chain reaction (RT-nested PCR) with the original common primers of MAGE-A1 to -A6 and analysis of correlation... -
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- Adenovirus adenine nucleotide translocator-2 shRNA effectively induces apoptosis and enhances chemosensitivity by the down-regulation of ABCG2 in breast cancer stem-like cells
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Jang JY, Kim MK, Jeon YK, Joung YK, Park KD, Kim CW
- KMID: 1365902
- Exp Mol Med.
- 2012 Apr;44(4):251-259.
- doi: 10.3858/emm.2012.44.4.019
Cancer stem cells (CSCs) are resistant to chemo- and radio-therapy, and can survive to regenerate new tumors. This is an important reason why various anti-cancer therapies often fail to completely... -
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- Sequence Analyses of Aberrant FHIT Transcripts in Gastric Cancer Cell Lines
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Lee SH, Kim HS
- KMID: 1066038
- Korean J Gastroenterol.
- 2003 Dec;42(6):476-483.
BACKGROUND/AIMS: The fragile histidine triad (FHIT) gene located at chromosome 3p14.2, is a candidate tumor suppressor gene often involved in various tumors. Homozygous deletions, lack or reduced expression of... -
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- Comparison of the Urine ThinPrep Test and Melanoma Antigen Gene RT-PCR for the Detection of Bladder Cancer According to Three Urine Collection Methods
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Kim DY, Cho HJ, Oh HK, Shin IH, Jeon CH
- KMID: 1121660
- Korean J Lab Med.
- 2007 Feb;27(1):50-55.
- doi: 10.3343/kjlm.2007.27.1.50
BACKGROUND: For the detection of transitional cell carcinoma (TCC) of the bladder, we compared the sensitivities and specificities between the ThinPrep test and Melanoma Antigen Gene (MAGE) test with... -
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- A Case of Therapy-related Acute Lymphoblastic Leukemia with t(11;19)(q23;p13.3) and MLL/MLLT1 Gene Rearrangement
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Yoo BJ, Nam MH, Sung HJ, Lim CS, Lee CK, Cho YJ, Lee KN, Yoon SY
- KMID: 1096654
- Korean J Lab Med.
- 2011 Jan;31(1):13-17.
- doi: 10.3343/kjlm.2011.31.1.13
Therapy-related ALL (t-ALL) is a rare secondary leukemia that develops after chemotherapy and/or radiotherapy for primary malignancies. Chromosomal 11q23 abnormalities are the most common karyotypic alterations in t-ALL. The t(11;19)(q23;p13)... -
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