- DNA Hypomethylation-Mediated Overexpression of Carbonic Anhydrase 9 Induces an Aggressive Phenotype in Ovarian Cancer Cells
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Sung HY, Ju W, Ahn JH
- KMID: 2070216
- Yonsei Med J.
- 2014 Nov;55(6):1656-1663.
- doi: 10.3349/ymj.2014.55.6.1656
PURPOSE: Both genetic and epigenetic alterations can lead to abnormal expression of metastasis-regulating genes in tumor cells. Recent studies suggest that aberrant epigenetic alterations, followed by differential gene expression, leads... -
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- MiR-152 suppresses the proliferation and invasion of NSCLC cells by inhibiting FGF2
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Cheng Z, Ma R, Tan W, Zhang L
- KMID: 2155377
- Exp Mol Med.
- 2014 Sep;46(9):e112.
- doi: 10.1038/emm.2014.51
MicroRNAs (miRNAs) regulate the proliferation and metastasis of cancer cells. Here, we showed that miR-152 was downregulated in non-small-cell lung cancer (NSCLC) tissues and cell lines. Overexpression of miR-152 suppressed... -
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- Enhanced expression of cathepsin L in metastatic bone tumors
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Park IC, Lee SY, Jeon DG, Lee JS, Hwang CS, Hwang YG, Lee SH, Hong WS, Hong SI
- KMID: 644942
- J Korean Med Sci.
- 1996 Apr;11(2):144-148.
- doi: 10.3346/jkms.1996.11.2.144
Cathepsin L is a kind of cystein proteases which are known to facilitate the invasion and metastasis of tumor cells by degrading the components of basement membrane and extracellular matrix.... -
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- Overexpression of Mucin 13 due to Promoter Methylation Promotes Aggressive Behavior in Ovarian Cancer Cells
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Sung HY, Park AK, Ju W, Ahn JH
- KMID: 1799482
- Yonsei Med J.
- 2014 Sep;55(5):1206-1213.
- doi: 10.3349/ymj.2014.55.5.1206
PURPOSE: Recent discoveries suggest that aberrant DNA methylation provides cancer cells with advanced metastatic properties. However, the precise regulatory mechanisms controlling metastasis genes and their role in metastatic transformation are... -
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