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Toxic Epidermal Necrolysis Associated with Sorafenib and Tosufloxacin in a Patient with Hepatocellular Carcinoma

Choi MK, Woo HY, Heo J, Cho M, Kim GH, Song GA, Kim MB

This is the first case report to describe a 44-year-old woman with a history of advanced hepatocellular carcinoma who developed toxic epidermal necrolysis (TEN) clinically after taking 400 mg sorafenib...
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Cytotoxicity and Structure-activity Relationships of Naphthyridine Derivatives in Human Cervical Cancer, Leukemia, and Prostate Cancer

Hwang YJ, Chung ML, Sohn UD, Im C

Naphthyridine compounds are important, because they exhibit various biological activities including anticancer, antimicrobial, and anti-inflammatory activity. Some naphthyridines have antimitotic effects or demonstrate anticancer activity by inhibiting topoisomerase II. These...
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Clinical Effects of Gemifloxacin on the Delay of Tuberculosis Treatment

Kim SY, Yim JJ, Park JS, Park SS, Heo EY, Lee CH, Chung HS, Kim DK

Although gemifloxacin has low in vitro activity against Mycobacterium tuberculosis, the effect of gemifloxacin on the delay of tuberculosis (TB) treatment has not been validated in a clinical setting. The...
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Antimicrobial Susceptibility Patterns of Legionella isolates in the Environment and in Patients

Choi GE, Kang JE, Lee EY, Chang CL, Tateda K, Yamaguchi , Kim KH, Kim JM

BACKGROUND: Antimicrobial susceptibility of Legionella spp. has rarely been studied in Korea. Therefore, we aimed to determine the susceptibility of Legionella spp. to various antibiotics. METHODS: We assessed the antimicrobial...
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In vitro Activity of Gemifloxacin Against Recent Clinical Isolates of Bacteria in Korea

Yong DE, Cheong HJ, Kim YS, Park YJ, Kim WJ, Woo JH, Lee KW, Kang MW, Choo YS

Gemifloxacin is an enhanced-affinity fluoroquinolone with broad-spectrum antibacterial activity. In Korea, resistant bacteria are relatively more prevalent than in other industrialized countries. In this study, we studied the in...
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