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Role of Glial Cells in Axonal Regeneration

Toy D, Namgung U

Axonal regeneration is critical for functional recovery following neural injury. In addition to intrinsic differences between regenerative responses of axons in peripheral versus central nervous systems, environmental factors such as...
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Cdk5 Phosphorylation of STAT3 in Dorsal Root Ganglion Neurons Is Involved in Promoting Axonal Regeneration After Peripheral Nerve Injury

Hwang J, Namgung U

Purpose: The goal of this study is to investigate the role of cyclin-dependent kinase 5 (Cdk5) in axonal regeneration in dorsal root ganglion (DRG) neurons after peripheral nerve injury. Methods: Crush...
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Tryptophan Negatively Regulates IgE-mediated Mast Cell Activation

Silwal P, Shin K, Choi S, Namgung U, Lee CY, Heo JY, Lim K, Park JI, Kim KH, Park SK

Mast cells are major immune cells in allergy to secrete allergic mediators by a degranulation process and make and secrete inflammatory lipids and cytokines in response to antigen stimulation. An...
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Activation of epidermal growth factor receptor is responsible for pervanadate-induced phospholipase D activation

Kim YR, Cha HY, Lim K, Hwang BD, Hoe KL, Namgung U, Park SK

  • KMID: 1097260
  • Exp Mol Med.
  • 2003 Apr;35(2):118-124.
Pervanadate, a complex of vanadate and H2O2, has an insulin mimetic effect, and acts as an inhibitor of protein tyrosine phosphatase. Pervanadate-induced phospholipase D (PLD) activation is known to be...
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Dexamethasone Induces FcgammaRIIb Expression in RBL-2H3 Cells

Silwal P, Lee MN, Lee CJ, Hong JH, Namgung U, Lee ZW, Kim J, Lim K, Kweon GR, Park JI, Park SK

Mast cells are involved in allergic responses, protection against pathogens and autoimmune diseases. Dexamethasone (Dex) and other glucocorticoids suppress FcepsilonRI-mediated release of inflammatory mediators from mast cells. The inhibition mechanisms...
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Adenine attenuates lipopolysaccharide-induced inflammatory reactions

Silwal P, Lim K, Heo JY, Park JI, Namgung U, Park SK

A nucleobase adenine is a fundamental component of nucleic acids and adenine nucleotides. Various biological roles of adenine have been discovered. It is not produced from degradation of adenine nucleotides...
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