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Forensic Consideration of Myocardial Reperfusion Injury Associated with Cardiac Valves Replacement and Coronary Artery Bypass Graft: A Case Report

Eom M, Choi YD, Kang GH, Min BW, Kim DH, Kim YS, Lee HY

  • KMID: 1928085
  • Korean J Leg Med.
  • 2005 Oct;29(2):146-151.
The most effective ways to salvage ischemic myocardium threatened by infarction is to restore tissue perfusion as rapidly as possible. These are best accomplished by restoration of coronary flow(reperfusion) by...
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Cardiodynamics and Infarct Size in Regional and Global Ischemic Isolated Heart Model: Comparison of 1 Hour and 2 Hours Reperfusion

Kim JH, Kim J, Park YH, Chun KJ, Kim JS, Jang YH, Lee MY, Xu Z

BACKGROUND AND OBJECTIVES: We investigated whether 1 hour reperfusion is enough to assess cardiodynamics and infarct size in both regional ischemia (RI) and global ischemia (GI) in isolated rat heart...
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Mechanism of Ischemia and Reperfusion Injury to the Heart: From the Viewpoint of Nitric Oxide and Mitochondria

Ha SJ, Kim W

After an acute myocardial infarction, early and successful myocardial reperfusion is the most effective strategy for reducing the size of a myocardial infarct and improving the clinical outcome. However, the...
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Nicardipine Augments Local Myocardial Perfusion after Coronary Artery Reperfusion in Dogs

Jang YH, Kim JM

Nicardipine is a potent coronary and systemic vasodilator without depression of ventricular function. We investigated the changes in local myocardial perfusion (LMP) according to the nicardipine administration after coronary reperfusion...
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Relationship between Initial Leukocyte Count and the Extent of Myocardial Injury in Patients with Acute Myocardial Infarction Who Received Reperfusion Therapy

Han J, Youn TJ, Hong ES, Yoon SI, Moon KW, Kim HE, Hahn J, Kim KS, Bae J, Hwang KK, Kim DW, Cho MC

BACKGROUND AND OBJECTIVES: The presence of leukocytosis in patients with acute myocardial infarction (AMI) has been reported to be related to the extent of MI and with the prognosis. However,...
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Measurement of Local Myocardial Perfusion by Thermal Diffusion Microprobe during Coronary Artery Occlusion and Reperfusion in a Beating Canine Heart

Jang YH, Kim JM

BACKGROUND: The measurement of perfusion is very important to understand the physiology of the tissue level. The QFlow(TM)400 perfusion measurement system is able to measure local tissue perfusion. The...
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Early Assessment of Reperfusion Therapy in Acute Myocardial Infarction Using Cardiac Troponin-T

Doo YC, Kim HS, Seo YI, Lee RY, Lee JM, Shin EC, Koh SH, Rim CY, Koh YB, Lee Y, Park JB

BACKGROUND: An earlier index of reperfusion is desirable to determine whether additional therapy is necessary for myocardial salvage. Using the washout phenomenon of biochemical markers, many investigator have reported noninvasive...
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The Effects of Intravenous Adenosine on Reperfusion Injury after Experimental Acute Myocardial Infarction in Open Chest Anesthetized Dogs

Oh BH, Kim DK, Sohn DW, Lee MM, Park YB, Choi YS, Seo JD, Lee YW

BACKGROUND: Since reperfusion early after acute myocardial infarction has been demonstrated to reduce the infarct size and mortality, many drugs and interventions to reduce the reperfusion injury have been tried...
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The 2017 Update of the Clinical Guidelines for ST-Segment Elevation Myocardial Infarction of the European Society of Cardiology

Bae JW

The 2017 Clinical Guidelines for ST-segment elevation myocardial infarction of the European Society of Cardiology updated many important aspects of the pre-hospital phase, the selection of a reperfusion strategy, interventional...
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Effects of L-Arginine on the Change of Myocardial Stunning

Park CG, Han SW, Lee EM, Jin DG, Kim YH, Yim DS, Seo HS, Shim WJ, Oh DJ, Ro YM

BACKGROUND: The effects of L-arginine-NO system on myocardial stunning haven't been well known. This work was designed to know whether L-arginine, physiologic NO precusor, would attenuate postischemic myocardial dysfunction or...
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Effects of Ivabradine on Left Ventricular Systolic Function and Cardiac Fibrosis in Rat Myocardial Ischemia-Reperfusion Model

Kim HB, Hong YJ, Park HJ, Ahn Y, Jeong MH

We evaluated the effects of Ivabradine on left ventricle (LV) ejection fraction (EF) and LV infarcted tissue in the rat myocardial ischemia-reperfusion model. Twenty rats were randomly assigned to group...
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Effects of Sodium Nitroprusside on Functional Recovery of Stunned Myocardium in Dogs

Yoo KY, Park CJ, Yoon OJ

Ischemia/reperfusion injury (myocardial stunning) may be mediated by oxygen derived-free radicals. Sodium nitroprusside (SNP), NO-donor, is known to reduce superoxide concentrations in isolated vascular tissue. To explore the efficacy of...
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Apoptosis in Ischemia-Reperfused Myocardium of Rabbit

Kim YK, Han DS, Lee MY, Kim MA, Lee HC, Park YT, Kim SH, Kim SS

BACKGROUND: Apoptosis, as opposed to necrosis, is a active and regulated mode of cell death. Persistent myocardial ischemia results in necrosis. The most effective method to limit ischemic myocardial injury...
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Expression of Bcl-2 Protein in Ischemia-Reperfused Myocardium of Rabbit

Kim SH, Park YT, Seo PW, Ryu JW, Park SS, Kim YK, Choi CH, Ryu GM, Kim SS

  • KMID: 1877466
  • Korean J Thorac Cardiovasc Surg.
  • 1998 Oct;31(10):924-927.
BACKGROUND: Myocardial cell death after myocardial infarction or reperfusion is classified into necrosis and apoptosis. Bcl-2 protein is a cytoplasmic protein, which inhibits apoptosis and is expressed in acute stage...
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Therapeutic Hypothermia for Cardioprotection in Acute Myocardial Infarction

Kang IS, Fumiaki I, Pyun WB

Mild therapeutic hypothermia of 32-35degrees C improved neurologic outcomes in outside hospital cardiac arrest survivor. Furthermore, in experimental studies on infarcted model and pilot studies on conscious patients with acute...
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Myocardial protective effect by ulinastatin via an anti-inflammatory response after regional ischemia/reperfusion injury in an in vivo rat heart model

Shin IW, Jang IS, Lee SM, Park KE, Ok SH, Sohn JT, Lee HK, Chung YK

BACKGROUND: Ulinastatin has anti-inflammatory properties and protects organs from ischemia/reperfusion-induced injury. The aim of this study was to investigate whether ulinastatin provides a protective effect on a regional myocardial ischemia/reperfusion...
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Absence and Resolution of Fragmented QRS Predict Reversible Myocardial Ischemia With Higher Probability of ST Segment Resolution in Patients With ST Segment Elevation Myocardial Infarction

Cetin M, Kocaman SA, Kiris T, Erdogan T, Canga A, Durakoglugil ME, Cicek Y, Dogan S, Satiroglu

BACKGROUND AND OBJECTIVES: Fragmented QRS complexes (fQRS) are associated with increased morbidity and mortality. The causative relationship between fQRS and cardiac fibrosis has been shown, but whether the presence and...
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Polyphenol (-)-epigallocatechin gallate targeting myocardial reperfusion limits infarct size and improves cardiac function

Kim CJ, Kim JM, Lee SR, Jang YH, Kim JH, Chun KJ

BACKGROUND: This experiment was performed to determine the effect of polyphenolic (-)-epigallocatechin (EGCG), the most abundant catechin of green tea, given at reperfusion period. METHODS: Isolated rat hearts were subjected...
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The Effect of High Dose Melatonin on Cardiac Ischemia-reperfusion Injury

Ceyran H, Narin F, Narin N, Akgun H, Ceyran AB, Ozturk F, Akcali Y

PURPOSE: Melatonin, the most potent scavenger of toxic free radicals, has been found to be effective in protecting against pathological states due to the release of reactive oxygen species. This...
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The Protective Effect of Adenosine Included Cardioplegia in Myocardial Ischemia

Yoo KJ, Kang MS, Lee KJ, Lim SH, Kim JH, Cho BK

  • KMID: 2061921
  • Korean J Thorac Cardiovasc Surg.
  • 1997 Sep;30(9):847-853.
Although the effects of adenosine on the heart, including the clinical suppression of cardiac arrhythmias, have been recognized for more than half a century, it is only in the last...
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