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Emerging strategies for the treatment of pulmonary tuberculosis: promise and limitations?

Yew WW, Koh WJ

A worsening scenario of drug-resistant tuberculosis has increased the need for new treatment strategies to tackle this worldwide emergency. There is a pressing need to simplify and shorten the current...
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Characterization of pncA Mutations of Pyrazinamide-Resistant Mycobacterium tuberculosis in Korea

Lee KW, Lee JM, Jung KS

Pyrazinamide (PZA) is one of the most important drugs for the treatment of Mycobacterium tuberculosis infection. However, the increasing frequency of PZA-resistant strains limits its effectiveness. In Korea, most PZA-resistant...
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Drug-resistance pattern of Mycobacterium tuberculosis strains from patients with pulmonary and extrapulmonary tuberculosis during 2006 to 2013 in a Korean tertiary medical center

Lee HY, Lee J, Lee YS, Kim MY, Lee HK, Lee YM, Shin JH, Ko Y

BACKGROUND/AIMS: We evaluated the trend in the rates of drug-resistant tuberculosis (TB) over time, as well as the difference in the drug-resistance pattern between pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis...
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Drug-resistant tuberculosis in a tertiary referral teaching hospital of Korea

Lee JH, Chang JH

  • KMID: 759556
  • Korean J Intern Med.
  • 2001 Sep;16(3):173-179.
BACKGROUND: Resistance of Mycobacterium tuberculosis strains is an increasing problem worldwide. Our purpose was to determine the prevalence of drug resistance (DR) and risk factors of DR in patients with...
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Drug Resistance Rates of Mycobacterium tuberculosis at a Private Referral Center in Korea

Choi JC, Lim SY, Suh GY, Chung MP, Kim H, Kwon OJ, Lee NY, Park YK, Bai GH, Koh WJ

The goals of this study were to identify first-line drug resistance in new and previously treated tuberculosis (TB) cases and to determine risk factors for multidrugresistant TB (MDR-TB) at a...
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Rapid Diagnosis of Tuberculosis and Multidrug Resistance Using a MGIT 960 System

Koh WJ, Ko Y, Kim CK, Park KS, Lee NY

BACKGROUND: The purpose of this study was to compare the turnaround time for liquid culturing and primary anti-tuberculous drug susceptibility testing (DST) performed using the mycobacteria growth indicator tube (MGIT)...
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Detection of Rifampin Resistant Mycobacterium tuberculosis complex using Denaturing HPLC

Nam YH, Lee SH, Ahn YC, Cho MH, Jang WC, Park SM, Kwon PS, Kim JW

BACKGROUND: Tuberculosis (TB) remains an important cause of morbidity and mortality throughout the world. The surge of TB has been accompanied by an increase in multi-drug-resistant tuberculosis (MDR-TB). In...
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Mutations in the embB Locus among Korean Clinical Isolates of Mycobacterium tuberculosis Resistant to Ethambutol

Lee HY, Myoung HJ, Bang HE, Bai GH, Kim SJ, Kim JD, Cho SN

Resistance of Mycobacterium tuberculosis to ethambutol (EMB) has been assigned to an operon, embCAB, which has been proposed to be a structural gene for mycobacterial arabinosyl transferases. Recently, genetic events...
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Retrospective Comparison of Levofloxacin and Moxifloxacin on Multidrug-Resistant Tuberculosis Treatment Outcomes

Lee J, Lee CH, Kim DK, Yoon HI, Kim JY, Lee SM, Yang SC, Lee JH, Yoo CG, Lee CT, Chung HS, Kim YW, Han SK, Yim JJ

BACKGROUND/AIMS: To compare the effect of levofloxacin and moxifloxacin on treatment outcomes among patients with multidrug-resistant tuberculosis (MDR-TB). METHODS: A retrospective analysis of 171 patients with MDR-TB receiving either levofloxacin or...
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