Korean J Intern Med.  2015 May;30(3):325-334. 10.3904/kjim.2015.30.3.325.

Drug-resistance pattern of Mycobacterium tuberculosis strains from patients with pulmonary and extrapulmonary tuberculosis during 2006 to 2013 in a Korean tertiary medical center

• Lee HY
• Lee J
• Lee YS
• Kim MY
• Lee HK
• Lee YM
• Shin JH
• Ko Y

• KMID: 2160705
• DOI: http://doi.org/10.3904/kjim.2015.30.3.325

Abstract

BACKGROUND/AIMS
We evaluated the trend in the rates of drug-resistant tuberculosis (TB) over time, as well as the difference in the drug-resistance pattern between pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) at a private referral center in South Korea.
METHODS
All patients with culture-confirmed TB from 2006 to 2013 were included.
RESULTS
In total, 1,745 patients were included: 1,431 (82.0%) were new cases, and 314 (18.0%) were cases treated previously; 1,610 (92.3%) were diagnosed with PTB, and 135 (7.7%) were diagnosed with EPTB. Multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB were detected in 5.8% and 2.0% of new cases and in 20.1% and 8.6% of previously treated cases, respectively. The MDR TB rate during the study period decreased remarkably, whereas the MDR and XDR TB rates decreased significantly in previously treated cases. No difference in the drug-resistance rate was detected between PTB and EPTB.
CONCLUSIONS
The TB drug-resistance rate, particularly that of MDR TB, remained high at a private referral hospital, and the drug-resistance rate did not decrease significantly from 2006 to 2013. This finding underscores the need for a national survey regarding the prevalence of drug-resistant TB to obtain the most accurate and current drug-resistance status in South Korea, including the private sector.

Keyword

Mycobacterium tuberculosis; Drug-resistance rate; Extrapulmonary tuberculosis; Korea

MeSH Terms

Adult
Aged
Antitubercular Agents/*therapeutic use
*Drug Resistance, Multiple, Bacterial
Extensively Drug-Resistant Tuberculosis/drug therapy/microbiology
Female
Hospitals, Private
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Mycobacterium tuberculosis/*drug effects/isolation & purification
Prevalence
Republic of Korea/epidemiology
Retrospective Studies
*Tertiary Care Centers
Time Factors
Treatment Outcome
Tuberculosis, Multidrug-Resistant/diagnosis/*drug therapy/epidemiology/*microbiology
Tuberculosis, Pulmonary/diagnosis/*drug therapy/epidemiology/*microbiology
Antitubercular Agents