- Expression of a recombinant branched chain alpha-oxo acid dehydrogenase complex E2 (BCOADC-E2) in insect cells and its immunoreactivity to autoimmune sera
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Lee SM, Ko SH, Park JE, Cha SH
- KMID: 754990
- Exp Mol Med.
- 1998 Jun;30(2):65-71.
Preparation of a pure autoantigen by way of recombinant DNA technology has an important value in an accurate diagnosis or prognosis of an autoimmune disease. BCOADC-E2 subunit, a mitochondrial protein, has been... -
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- Protective Effects of Immunization with Proteinase, Phospholipase and Cell Wall Proteins of Candida albicans in Mice Candidosis
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Shin WS, Choi SJ, Yang YC, Park SJ, Park JY, Kim SK, Lee KH
- KMID: 1474500
- Korean J Med Mycol.
- 2009 Mar;14(1):9-15.
BACKGROUND: The opportunistic fungus Candida albicans is a major pathogen especially to immunocompromised patients. OBJECTIVES: We examined the protective effect of the active and passive immunizations to evaluate the applicability for... -
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- Clinical Characteristics and Molecular Genetic Analysis of Korean Patients with GNE Myopathy
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Sim JE, Park HJ, Shin HY, Nam TS, Kim SM, Choi YC
- KMID: 1727867
- Yonsei Med J.
- 2013 May;54(3):578-582.
- doi: 10.3349/ymj.2013.54.3.578
PURPOSE: Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE) myopathy is an autosomal recessive neuromuscular disorder characterized by early adult-onset weakness of the distal muscles of the lower limbs. The clinical spectrum of GNE... -
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- Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells
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Kim YM, Song I, Seo YH, Yoon G
- KMID: 2169308
- Endocrinol Metab.
- 2013 Dec;28(4):297-308.
- doi: 10.3803/EnM.2013.28.4.297
BACKGROUND: Enhanced lipogenesis plays a critical role in cell senescence via induction of expression of the mature form of sterol regulatory element binding protein 1 (SREBP1), which contributes to an... -
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- Characterization of cis-acting elements in the rat ATP citrate-lyase gene promoter
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Moon YA, Park SW, Kim KS
- KMID: 1093599
- Exp Mol Med.
- 2002 Mar;34(1):60-68.
The cis-acting element in the promoter of the rat ATP-citrate lyase (ACL) and transcription factors which interact with these elements were determined. Six Sp1 binding sites and CAAT box exist... -
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- The Levels of MDM2 Protein Are Decreased by a Proteasome-Mediated Proteolysis Prior to Caspase-3-Dependent pRb and PARP Cleavages
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Cho JW, Park JC, Lee JC, Kwon TK, Park JW, Baek WK, Suh SI, Suh MH
- KMID: 648246
- J Korean Med Sci.
- 2001 Apr;16(2):135-139.
- doi: 10.3346/jkms.2001.16.2.135
MDM2 is a substrate of caspase-3 in p53-mediated apoptosis. In addition, MDM2 mediates its own ubiquitination in a RING finger-dependent manner. Thus, we investigated whether MDM2 is degraded through a... -
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- Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase
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Park CE, Kim MJ, Lee JH, Min BI, Bae H, Choe W, Kim SS, Ha J
- KMID: 1094663
- Exp Mol Med.
- 2007 Apr;39(2):222-229.
trans-Resveratrol (t-RVT), a naturally occurring polyphenol found in Polygonum cuspidatum, grape, and red wine, has been reported to have anti- inflammatory, cardioprotective, and cancer chemopreventive properties. However antidiabetic effect of... -
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- Expression of 3b-Hydroxysteroid dehydrogenase and P450 side chain cleavage enzyme in the human uterine endometrium
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Rhee HS, Oh SH, Ko BJ, Han DM, Jeon BH, Park H, Moon HB, Kim WS
- KMID: 1094696
- Exp Mol Med.
- 2003 Jun;35(3):160-166.
The enzyme complex 3b-hydroxysteroid dehydrogenase/delta(5)-delta(4)-isomerase (3beta-HSD) is involved in the biosynthesis of all classes of active steroids. The expression of 3beta-HSD in human uterine endometrium during the menstrual cycle and... -
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- Inhibition of rac1 Reduces PDGF-induced Reactive Oxygen Species and Proliferation in Vascular Smooth Muscle Cells
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Kong G, Lee S, Kim KS
- KMID: 648350
- J Korean Med Sci.
- 2001 Dec;16(6):712-718.
- doi: 10.3346/jkms.2001.16.6.712
In vascular smooth muscle cells, reactive oxygen species (ROS) were known to mediate platelet-derived growth factor (PDGF)-induced cell proliferation and NADH/NADPH oxidase is the major source of ROS. NADH/NADPH oxidase... -
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- Aging impairs insulin-stimulated glucose uptake in rat skeletal muscle via suppressing AMPKalpha
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Qiang W, Weiqiang K, Qing Z, Pengju Z, Yi L
- KMID: 756077
- Exp Mol Med.
- 2007 Aug;39(4):535-543.
Insufficient intracellular fat oxidation is an important contributor to aging-related insulin resistance, while the precise mechanism underlying is unclear. AMP-activated protein kinase (AMPK) is an important regulator of intracellular fat... -
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- Exercise type and muscle fiber specific induction of caveolin-1 expression for insulin sensitivity of skeletal muscle
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Oh YS, Kim HJ, Ryu SJ, Cho KA, Park YS, Park H, Kim M, Kim CK, Park SC
- KMID: 1047091
- Exp Mol Med.
- 2007 Jun;39(3):395-401.
It is well known that exercise can have beneficial effects on insulin resistance by activation of glucose transporter. Following up our previous report that caveolin-1 plays an important role in... -
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- Identification of a Novel Single Nucleotide Polymorphism of HADHA Gene at a Referred Primer-binding Site During Pre-diagnostic Tests for Preimplantation Genetic Diagnosis
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Lee HS, Choi HW, Lim CK, Koong MK, Kang IS, Yoo HW, Choi JH, Jun JH
- KMID: 1781894
- J Korean Med Sci.
- 2006 Oct;21(5):794-799.
- doi: 10.3346/jkms.2006.21.5.794
The pre-diagnostic test for preimplantation genetic diagnosis (PGD) of long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency was performed by polymerase chain reaction (PCR) and direct sequencing for hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme A thiolase/enoyl-Coenzyme A... -
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