- Functional Role of a Conserved Sequence Motif in the Oxygen-dependent Degradation Domain of Hypoxia-inducible Factor 1 alpha in the Recognition of p53
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Chi SW
- KMID: 2166342
- Genomics Inform.
- 2008 Jun;6(2):72-76.
Hypoxia-inducible factor 1 alpha (HIF1 alpha) is a transcription factor that plays a key role in the adaptation of cells to low oxygen stress and oxygen homeostasis. The oxygen-dependent degradation... -
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- Structural Analysis of Recombinant Human Preproinsulins by Structure Prediction, Molecular Dynamics, and Protein-Protein Docking
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Jung SH, Kim CK, Lee G, Yoon J, Lee M
- KMID: 2404051
- Genomics Inform.
- 2017 Dec;15(4):142-146.
- doi: 10.5808/GI.2017.15.4.142
More effective production of human insulin is important, because insulin is the main medication that is used to treat multiple types of diabetes and because many people are suffering from... -
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- Quercetin Directly Interacts with Vitamin D Receptor (VDR): Structural Implication of VDR Activation by Quercetin
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Lee KY, Choi HS, Choi HS, Chung KY, Lee BJ, Maeng HJ, Seo MD
- KMID: 2170532
- Biomol Ther.
- 2016 Mar;24(2):191-198.
- doi: 10.4062/biomolther.2015.122
The vitamin D receptor (VDR) is a member of the nuclear receptor (NR) superfamily. The VDR binds to active vitamin D3 metabolites, which stimulates downstream transduction signaling involved in various... -
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- Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase: Enoyl Reductase and beta-Ketoacyl Reductase Catalytic Domains
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John A, Umashankar V, Krishnakumar S, Deepa PR
- KMID: 2053332
- Genomics Inform.
- 2015 Mar;13(1):15-24.
- doi: 10.5808/GI.2015.13.1.15
Fatty acid synthase (FASN, EC 2.3.1.85), is a multi-enzyme dimer complex that plays a critical role in lipogenesis. This lipogenic enzyme has gained importance beyond its physiological role due to... -
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- Understanding Rifampicin Resistance in Tuberculosis through a Computational Approach
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Kumar S, Jena L
- KMID: 2391508
- Genomics Inform.
- 2014 Dec;12(4):276-282.
- doi: 10.5808/GI.2014.12.4.276
The disease tuberculosis, caused by Mycobacterium tuberculosis (MTB), remains a major cause of morbidity and mortality in developing countries. The evolution of drug-resistant tuberculosis causes a foremost threat to global... -
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- Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Toxoplasma gondii Apical Membrane Antigen 1 (AMA1)
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Vetrivel U, Muralikumar S, Mahalakshmi B, Lily Therese K, Madhavan H, Alameen M, Thirumudi
- KMID: 2328166
- Genomics Inform.
- 2016 Jun;14(2):53-61.
- doi: 10.5808/GI.2016.14.2.53
Toxoplasma gondii is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. It causes encephalitis, uveitis, chorioretinitis, and congenital infection. T. gondii invades the host cell by... -
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- Voltage Regulation of Connexin Channel Conductance
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Oh S, Bargiello
- KMID: 2352783
- Yonsei Med J.
- 2015 Jan;56(1):1-15.
- doi: 10.3349/ymj.2015.56.1.1
Voltage is an important parameter that regulates the conductance of both intercellular and plasma membrane channels (undocked hemichannels) formed by the 21 members of the mammalian connexin gene family. Connexin... -
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- Comparative Analyses of Signature Genes in Acute Rejection and Operational Tolerance
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Choi JW, Kim YH, Oh JW
- KMID: 2388078
- Immune Netw.
- 2017 Aug;17(4):237-249.
- doi: 10.4110/in.2017.17.4.237
Using biomarkers as prediction tools or therapeutic targets can be a valuable strategy in transplantation. Recent studies identified biomarkers of acute rejection (AR) and operational tolerance (TOL) through the application... -
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- Localized In Vivo 1H MRS ( Proton Magnetic Resonance Spectroscopy ) for Histologic Type of the Cervical Cancer
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Na JH, Kim YM, Lee JH, Cho KS, Kim JH, Kim YT, Nam CH, Mok JE
- KMID: 2269566
- Korean J Obstet Gynecol.
- 1998 Jun;41(6):1606-1612.
Most of cervical cancers are squamous cell type and the majority of the remaining 10% to 15% are adenocarcinoma. The clinical features of these two histological types of cancers are... -
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- A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the Toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-kappaB pathway in BV2 microglial cells
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Lee YH, Jeon SH, Kim SH, Kim C, Lee SJ, Koh D, Lim Y, Ha K, Shin SY
- KMID: 1383799
- Exp Mol Med.
- 2012 Jun;44(6):369-377.
Microglial cells are the resident innate immune cells that sense pathogens and tissue injury in the central nervous system (CNS). Microglial activation is critical for neuroinflammatory responses. The synthetic compound... -
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