- Effect of kainic acid on the phosphorylation of mitogen activated protein kinases in rat hippocampus
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Won JS, Lee JK, Choi SS, Song DK, Huh SO, Kim YH, Suh HW
- KMID: 1607133
- Korean J Physiol Pharmacol.
- 2001 Dec;5(6):451-456.
In rat hippocampus, kainic acid (KA; 10 mg/kg; i.p.) increased the phosphorylated forms of ERK1/2 (p-ERK1/2) and Jun kinase1 (p-JNK1), but not p-JNK2 and p38 (p-p38). The preadministration with cycloheximide... -
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- Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection
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Singh L, Kulshrestha R, Singh N, Jaggi AS
- KMID: 2410087
- Korean J Physiol Pharmacol.
- 2018 May;22(3):225-234.
- doi: 10.4196/kjpp.2018.22.3.225
Adenosine is a naturally occurring breakdown product of adenosine triphosphate and plays an important role in different physiological and pathological conditions. Adenosine also serves as an important trigger in ischemic... -
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- Therapeutic Inhibitors against Mutated BRAF and MEK for the Treatment of Metastatic Melanoma
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Ryu S, Youn C, Moon AR, Howland A, Armstrong , Song PI
- KMID: 2390430
- Chonnam Med J.
- 2017 Sep;53(3):173-177.
- doi: 10.4068/cmj.2017.53.3.173
Melanoma is one of the most aggressive cancers in the world and is responsible for the majority of skin cancer deaths. Recent advances in the field of immunotherapy using active,... -
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- Molecular assembly of mitogen-activated protein kinase module in ras-transformed NIH3T3 cell line
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Park KS, Kim JA, Chai KJ
- KMID: 755075
- Exp Mol Med.
- 2000 Sep;32(3):120-126.
The ras, is a G-like protein that controls the mitogen-activated protein kinase (MAPK) pathway involved in control and differentiation of cell growth. MAPK is a key component of its... -
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- CD137 induces adhesion and cytokine production in human monocytic THP-1 cells
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Choi JW, Lee HW, Roh GS, Kim HH, Kwack KB
- KMID: 755745
- Exp Mol Med.
- 2005 Apr;37(2):78-85.
CD137, which is expressed on activated T cells, plays a critical role in inflammatory responses. However, the exact role that CD137 plays in monocytes is not fully known. Here we... -
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- The Effects of Retinoic Acid and MAPK Inhibitors on Phosphorylation of Smad2/3 Induced by Transforming Growth Factor β1
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Lee SH, Shin JH, Shin MH, Kim YS, Chung KS, Song JH, Kim SY, Kim EY, Jung JY, Kang YA, Chang J, Park MS
- KMID: 2441729
- Tuberc Respir Dis.
- 2019 Jan;82(1):42-52.
- doi: 10.4046/trd.2017.0111
BACKGROUND: Transforming growth factor β (TGF-β), retinoic acid (RA), p38 mitogen-activated protein kinase (MAPK), and MEK signaling play critical roles in cell differentiation, proliferation, and apoptosis. We investigated the effect... -
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- Phosphoproteomic analysis identifies activated MET-axis PI3K/AKT and MAPK/ERK in lapatinib-resistant cancer cell line
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Lee YY, Kim HP, Kang MJ, Cho BK, Han SW, Kim TY, Yi EC
- KMID: 2154283
- Exp Mol Med.
- 2013 Nov;45(11):e64.
Lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) tyrosine kinases, has shown promising results as a growth inhibitor of HER2-positive... -
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- Current Status of Molecular Targeted Therapies in Hepatocellular Carcinoma
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Suh SJ, Yim HJ
- KMID: 1501636
- Korean J Gastroenterol.
- 2013 Mar;61(3):136-146.
- doi: 10.4166/kjg.2013.61.3.136
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in Korea. Curative treatment is only possible when the disease is diagnosed at the early stage. The prognosis... -
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- Role of sphingomyelin-MAPKs pathway in heat-induced apoptosis
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Chung HS, Park SR, Choi EK, Park HJ, Griffin RJ, Song CW, Park H
- KMID: 1094699
- Exp Mol Med.
- 2003 Jun;35(3):181-188.
The role of sphingomyelinase (SMase) activation and mitogen activated protein kinases (MAPKs) activation in cellular apoptosis was investigated during the hyperthermic treatment of HL-60 human leukemia cells. Treating the cells... -
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- Recent Update of Molecular Targeted Therapy in Pancreatic Cancer
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Cho JH
- KMID: 1501637
- Korean J Gastroenterol.
- 2013 Mar;61(3):147-154.
- doi: 10.4166/kjg.2013.61.3.147
Pancreatic ductal adenocarcinoma is one of the most dreaded malignancies and the 5th leading cause of cancer-related death in Korea. Late diagnosis and unfavorable response to both chemotherapy and radiotherapy... -
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- Combination treatment with 2-methoxyestradiol overcomes bortezomib resistance of multiple myeloma cells
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Song IS, Jeong YJ, Jeong SH, Heo HJ, Kim HK, Lee SR, Ko TH, Youm JB, Kim N, Ko KS, Rhee BD, Han J
- KMID: 2154269
- Exp Mol Med.
- 2013 Oct;45(10):e50.
Bortezomib is a proteasome inhibitor used for the treatment of relapsed/refractory multiple myeloma (MM). However, intrinsic and acquired resistance to bortezomib has already been observed in MM patients. In a... -
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- Cellular Proliferative Effect of Dexamethasone in Immortalized Trabecular Meshwork Cell (TM5) Line
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Jeon JW, Lee SJ, Kim JB, Kang JJ, Lee JH, Seong GJ, Kim EK
- KMID: 1779480
- Yonsei Med J.
- 2003 Apr;44(2):299-306.
- doi: 10.3349/ymj.2003.44.2.299
Dexamethasone (DEX), one of the corticosteroid hormones, is one of the most common therapeutic strategies in ophthalmological treatment. Despite its widespread use and clinical efficiency, little is known regarding the... -
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- Butyrate regulates leptin expression through different signaling pathways in adipocytes
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Soliman MM, Ahmed MM, Salah-eldin AE, Abdel-Aal
- KMID: 1365014
- J Vet Sci.
- 2011 Dec;12(4):319-323.
- doi: 10.4142/jvs.2011.12.4.319
Leptin is an adipocytokine that regulates body weight, and maintains energy homeostasis by promoting reduced food intake and increasing energy expenditure. Leptin expression and secretion is regulated by various factors... -
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- Extracellular HIV-1 Tat up-regulates expression of matrix metalloproteinase-9 via a MAPK-NF-kappaB dependent pathway in human astrocytes
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Ju SM, Song HY, Lee JA, Lee SJ, Choi SY, Park J
- KMID: 1109431
- Exp Mol Med.
- 2009 Feb;41(2):86-93.
- doi: 10.3858/emm.2009.41.2.011
The infiltration of monocytes into the CNS represents one of the early steps to inflammatory events in AIDS-related encephalitis and dementia. Increased activity of selected matrix metalloproteinases (MMPs) such as... -
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- Could HBx Protein Expression Affect Signal Pathway Inhibition by Gefitinib or Selumetinib, a MEK Inhibitor, in Hepatocellular Carcinoma Cell Lines?
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Park YK, Kim KM, Lee YJ, Kim KH, Lee SG, Lee D, Shim JH, Lim YS, Lee HC, Chung YH, Lee YS, Suh DJ
- KMID: 1782109
- J Korean Med Sci.
- 2011 Feb;26(2):214-221.
- doi: 10.3346/jkms.2011.26.2.214
Hepatitis B virus X (HBx) protein has been known to play an important role in development of hepatocellular carcinoma (HCC). The aim of this study is to find out whether... -
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- The Inhibition of Insulin-stimulated Proliferation of Vascular Smooth Muscle Cells by Rosiglitazone Is Mediated by the Akt-mTOR-P70S6K Pathway
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Park S, Lim S, Chang W, Song H, Lee S, Song BW, Kim HJ, Cha MJ, Choi E, Jang Y, Chung N, Cho SY, Hwang KC
- KMID: 1793194
- Yonsei Med J.
- 2008 Aug;49(4):592-600.
- doi: 10.3349/ymj.2008.49.4.592
PURPOSE: Thiazolidinediones (TZDs) are known to inhibit the proliferation of vascular smooth muscle cell (VSMC) by increasing the activity of p27(Kip1) and retinoblastoma protein (RB). However, the upstream signaling mechanisms... -
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- Sodium tanshinone IIA sulfonate depresses angiotensin II-induced cardiomyocyte hypertrophy through MEK/ERK pathway
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Yang L, Zou X, Liang Q, Chen H, Feng J, Yan L, Wang Z, Zhou D, Li S, Yao S, Zheng Z
- KMID: 1103682
- Exp Mol Med.
- 2007 Feb;39(1):65-73.
Cardiomyocyte hypertrophy is a major cause of morbidity and mortality worldwide. The aim of this study is to determine the effects of sodium tanshinone IIA sulfonate (STS) on cardiomyocyte hypertrophy... -
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- Interleukin-1 beta Induces MUC2 Gene Expression and Mucin Secretion via Activation of PKC-MEK/ERK,and PI3K in Human Airway Epithelial Cells
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Kim YD, Jeon JY, Woo HJ, Lee JC, Chung JH, Song SY, Yoon SK, Baek SH
- KMID: 648785
- J Korean Med Sci.
- 2002 Dec;17(6):765-771.
- doi: 10.3346/jkms.2002.17.6.765
Interleukin 1 beta (IL-1 beta), a proinflammatory cytokine, is related with inflammatory diseases and it up-regulates MUC2 gene expression and mucin secretion. This study was designed to investigate the... -
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- STAT3 is involved in phosphatidic acid-induced Bcl-2 expression in HeLa cells
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Choi HJ, Lee JH, Park SY, Cho JH, Han JS
- KMID: 1109432
- Exp Mol Med.
- 2009 Feb;41(2):94-101.
- doi: 10.3858/emm.2009.41.2.012
Phosphatidic acid (PA), the product of a PLD-mediated reaction, is a lipid second messenger that participates in various intracellular signaling events and is known to regulate a growing list of... -
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- Differential regulation of inducible nitric oxide synthase and cyclooxygenase-2 expression by superoxide dismutase in lipopolysaccharide stimulated RAW 264.7 cells
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Lee JA, Song HY, Ju SM, Lee SJ, Kwon HJ, Eum WS, Jang SH, Choi SY, Park J
- KMID: 756206
- Exp Mol Med.
- 2009 Sep;41(9):629-637.
- doi: 10.3858/emm.2009.41.9.069
Inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) have been known to be involved in various pathophysiological processes such as inflammation. This study was performed to determine the regulatory... -
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