- Mitochondrial Permeability Transition Pore and Cardioprotection Against Ischemia-reperfusion Injury
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Lee JW, Shim YH
- KMID: 2188082
- J Korean Med Assoc.
- 2009 Oct;52(10):1007-1019.
- doi: 10.5124/jkma.2009.52.10.1007
Opening of mitochondrial permeability transition pore (mPTP) was found to have a critical role in cell death from ischemia/reperfusion (I/R) injury experimentally in the late 1980's. Thereafter, tremendous efforts have... -
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- The changes of mitochondrial cytochrome c and GABAergic neuron in neuropathic pain model
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Kim WS, Park JY, Kim TK, Baik SW
- KMID: 2238034
- Korean J Anesthesiol.
- 2012 Apr;62(4):365-370.
- doi: 10.4097/kjae.2012.62.4.365
BACKGROUND: Role of cytochrome c (Cyt c) is an apoptogenic agent under certain conditions. The mitochondrial permeability transition pore (MPTP) plays an important role in cell death since it opens,... -
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- 4-hydroxy-2(E)-Nonenal facilitates NMDA-Induced Neurotoxicity via Triggering Mitochondrial Permeability Transition Pore Opening and Mitochondrial Calcium Overload
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Choi IY, Lim JH, Kim C, Song HY, Ju C, Kim WK
- KMID: 2165482
- Exp Neurobiol.
- 2013 Sep;22(3):200-207.
- doi: 10.5607/en.2013.22.3.200
N-methyl-D-aspartate (NMDA) receptor-mediated excitotoxicity is one of the major causes for neuronal cell death during cerebral ischemic insult. Previously, we reported that the final product of lipid membrane peroxidation 4-hydroxy-2E-nonenal... -
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- Morphine and remifentanil-induced cardioprotection: its experimental and clinical outcomes
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Kim JM, Jang YH, Kim J
- KMID: 2092315
- Korean J Anesthesiol.
- 2011 Nov;61(5):358-366.
- doi: 10.4097/kjae.2011.61.5.358
During the past few decades, a large number of animal studies demonstrated that commonly used opioids could provide cardioprotection against ischemia-reperfusion (I/R) injury. Opioid-induced preconditioning or postconditioning mimics ischemic preconditioning... -
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- Morphine-induced postconditioning modulates mitochondrial permeability transition pore opening via delta-1 opioid receptors activation in isolated rat hearts
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Kim JH, Chun KJ, Park YH, Kim J, Kim JS, Jang YH, Lee MY, Park JH
- KMID: 2092306
- Korean J Anesthesiol.
- 2011 Jul;61(1):69-74.
- doi: 10.4097/kjae.2011.61.1.69
BACKGROUND: It is generally accepted that morphine affords cardioprotection against ischemia/reperfusion injury. Inhibition of the mitochondrial permeability transition pore (MPTP) is considered an end target for cardioprotection. The aim of... -
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- Ischemic Postconditioning Inhibits Mitochondrial Permeability Transition Pore via Opioid Receptor Activation in Intact Rat Heart
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Lee YC, Jang YH, Kim JM, Kim AR, Lee SR, Kim YN, Hong JH
- KMID: 2239820
- Korean J Anesthesiol.
- 2008 Mar;54(3):320-327.
- doi: 10.4097/kjae.2008.54.3.320
BACKGROUND: Ischemic postconditioning (Post-C), brief cycles of myocardial ischemia and reperfusion during the early phase of reperfusion, is considered as a novel adjunct strategy to protect myocardium.However, the exact mechanism... -
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- A Population-Based Genomic Study of Inherited Metabolic Diseases Detected Through Newborn Screening
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Park KJ, Park S, Lee E, Park JH, Park JH, Park HD, Lee SY, Kim JW
- KMID: 2373595
- Ann Lab Med.
- 2016 Nov;36(6):561-572.
- doi: 10.3343/alm.2016.36.6.561
BACKGROUND: A newborn screening (NBS) program has been utilized to detect asymptomatic newborns with inherited metabolic diseases (IMDs). There have been some bottlenecks such as false-positives and imprecision in the... -
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- Cardioprotective signaling cascade of A2 adenosine receptor agonist 5'-N-ethylcarboxaminidoadenosine against myocardial reperfusion injury
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Lee YC, Jang YH, Kim CJ, Kim JM
- KMID: 1782548
- Korean J Anesthesiol.
- 2008 Dec;55(6):716-722.
- doi: 10.4097/kjae.2008.55.6.716
BACKGROUND: This experiments investigated the signaling cascade responsible for anti-infarct effect by an A2 adenosine receptor (AR) agonist 5'-N-Ethylcarboxaminidoadenosine (NECA). METHODS: Langendorff perfused isolated rat hearts were subjected to 30 minutes... -
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- Cilostazol Protects Endothelial Cells Against Lipopolysaccharide-Induced Apoptosis Through ERK1/2- and P38 MAPK-Dependent Pathways
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Lim JH, Woo JS, Shin YW
- KMID: 1717961
- Korean J Intern Med.
- 2009 Jun;24(2):113-122.
- doi: 10.3904/kjim.2009.24.2.113
BACKGROUND/AIMS: We examined the effects of cilostazol on mitogen-activated protein kinase (MAPK) activity and its relationship with cilostazol-mediated protection against apoptosis in lipopolysaccharide (LPS)-treated endothelial cells. METHODS: Human umbilical vein... -
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