- Effects of Endothelin on Potassium Currents in Primary Cultured Rat Microglia
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Bae JH
- KMID: 2298533
- Korean J Aerosp Environ Med.
- 2001 Mar;11(1):24-31.
BACKGROUND: Endothelin (ET), potent vasoconstricting peptide, are produced by endothelial cells after brain insults such as ischemia or infection and may play a role in the amplification or regulation of... -
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- Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes
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Lee JW, Nam H, Yu SW
- KMID: 2354879
- Exp Neurobiol.
- 2016 Oct;25(5):262-268.
- doi: 10.5607/en.2016.25.5.262
Translocator protein 18 kDa (TSPO) is a mitochondrial protein highly expressed on reactive microglia and astrocytes, and is considered as a biomarker for neurodegeneration and brain damage, especially neuroinflammation. Toll-like... -
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- Role of Spinal Microglia in Visceral Hyperalgesia and NK1R Up-Regulation in a Rat Model of Chronic Stress (Gastroenterology 2009;136:1339-1348)
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Hong SJ
- KMID: 2326128
- J Neurogastroenterol Motil.
- 2010 Jan;16(1):101-103.
No abstract available. -
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- miR-Let7A Modulates Autophagy Induction in LPS-Activated Microglia
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Song J, Oh Y, Lee JE
- KMID: 2165545
- Exp Neurobiol.
- 2015 Jun;24(2):117-125.
- doi: 10.5607/en.2015.24.2.117
Microglia regulate the secretion of various immunomediators in central nervous system diseases. Microglial autophagy is the crucial process for cell's survival and cytokine productions. Recent studies have reported that several... -
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- Microglia in the normally aged hippocampus
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Choi JH, Won MH
- KMID: 1850044
- Lab Anim Res.
- 2011 Sep;27(3):181-187.
- doi: 10.5625/lar.2011.27.3.181
The hippocampus plays important roles in the regulation and combination of short and long term memory and spatial navigation with other brain centers. Aging is accompanied by a functional decline... -
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- Relationship between Microglial Activation and Dopaminergic Neuronal Loss in 6-OHDA-induced Parkinsonian Animal Model
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Lee JS, Lee JY, Cho WG, Yang YC, Cho BP
- KMID: 1430195
- Korean J Phys Anthropol.
- 2013 Mar;26(1):13-23.
- doi: 10.11637/kjpa.2013.26.1.13
This study assessed the dynamics of morphological and immunophenotypic properties of activated microglia in a 6-hydroxydopamine (6-OHDA) induced Parkinsonian animal model. Neurodegeneration in the substantia nigra pars compacta (SNc) was... -
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- Astrocytes, Microglia, and Parkinson's Disease
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Joe EH, Choi DJ, An J, Eun JH, Jou I, Park S
- KMID: 2410468
- Exp Neurobiol.
- 2018 Apr;27(2):77-87.
- doi: 10.5607/en.2018.27.2.77
Astrocytes and microglia support well-being and well-function of the brain through diverse functions in both intact and injured brain. For example, astrocytes maintain homeostasis of microenvironment of the brain through... -
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- HMGB1-Binding Heptamer Confers Anti-Inflammatory Effects in Primary Microglia Culture
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Kim ID, Lee JK
- KMID: 2284633
- Exp Neurobiol.
- 2013 Dec;22(4):301-307.
- doi: 10.5607/en.2013.22.4.301
High mobility group box 1 (HMGB1) is an endogenous danger signal molecule. In the postischemic brain, HMGB1 is massively released during NMDA-induced acute damage and triggers inflammatory processes. In a... -
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- M2 Phenotype Microglia-derived Cytokine Stimulates Proliferation and Neuronal Differentiation of Endogenous Stem Cells in Ischemic Brain
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Choi JY, Kim JY, Kim JY, Park J, Lee WT, Lee JE
- KMID: 2368653
- Exp Neurobiol.
- 2017 Feb;26(1):33-41.
- doi: 10.5607/en.2017.26.1.33
Microglia play a key role in the immune response and inflammatory reaction that occurs in response to ischemic stroke. Activated microglia promote neuronal damage or protection in injured brain tissue.... -
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- Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease
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Kim YS, Joh TH
- KMID: 1110117
- Exp Mol Med.
- 2006 Aug;38(4):333-347.
Inflammation, a self-defensive reaction against various pathogenic stimuli, may become harmful self-damaging process. Increasing evidence has linked chronic inflammation to a number of neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's... -
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- Role of TGF-beta in Survival of Phagocytizing Microglia: Autocrine Suppression of TNF-alpha Production and Oxidative Stress
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Ryu KY, Cho GS, Piao HZ, Kim WK
- KMID: 2165414
- Exp Neurobiol.
- 2012 Dec;21(4):151-157.
- doi: 10.5607/en.2012.21.4.151
Microglia are recognized as residential macrophageal cells in the brain. Activated microglia play a critical role in removal of dead or damaged cells through phagocytosis activity. During phagocytosis, however, microglia... -
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- Reactive Plasticity of Neuroglial Cells on Brain Lesion
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Ahn ET, Ko JS, Park KH
- KMID: 1937881
- Korean J Anat.
- 1998 Oct;31(5):711-725.
Neuroglial cells are actively participate in the pathogenesis or in the recovery procedures following brain lesions. The study was performed to evaluate the plasticity of glial cells following different degree... -
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- Regulatory Effect of 25-hydroxyvitamin D3 on Nitric Oxide Production in Activated Microglia
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Hur J, Lee P, Kim MJ, Cho YW
- KMID: 2285538
- Korean J Physiol Pharmacol.
- 2014 Oct;18(5):397-402.
- doi: 10.4196/kjpp.2014.18.5.397
Microglia are activated by inflammatory and pathophysiological stimuli in neurodegenerative diseases, and activated microglia induce neuronal damage by releasing cytotoxic factors like nitric oxide (NO). Activated microglia synthesize a significant... -
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- Reactive Oxygen Species Production, Expression of Complement Regulator Genes and Phagocytosis in the Murine Microglial Cell after Administration of Beta-Amyloid(A beta1-42) Protein
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Choi YS, Lee KS, Kim SH
- KMID: 1626985
- J Korean Neurol Assoc.
- 2005 Feb;23(1):88-95.
BACKGROUND: Microglia is a primary cellular component of neuritic plaques in Alzheimer's disease. Beta amyloid deposits attract microglia and activate them to produce inflammatory mediators. The objectives of this study... -
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- Gene Expression Profile in Microglia following Ischemia-Reperfusion Injury
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Oh JH, Han HS, Park JS
- KMID: 1587394
- Korean J Physiol Pharmacol.
- 2006 Aug;10(4):173-180.
Microglial activation is thought to play a role in the pathogenesis of many brain disorders. Therefore, understanding the response of microglia to noxious stimuli may provide insights into their role... -
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- Inflammation as the Potential Basis in Depression
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Maeng SH, Hong H
- KMID: 2467314
- Int Neurourol J.
- 2019 Nov;23(Suppl 2):S63-S71.
- doi: 10.5213/inj.1938226.113
There is growing evidence of the association between inflammation and stress-related disorders including depression. The positive correlation between the increased levels of inflammatory cytokines observed in patients with other diseases... -
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- LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation
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Ho DH, Je AR, Lee H, Son I, Kweon HS, Kim HG, Seol W
- KMID: 2416244
- Exp Neurobiol.
- 2018 Jun;27(3):171-180.
- doi: 10.5607/en.2018.27.3.171
Leucine-rich repeat kinase 2 (LRRK2) mutations are the most common genetic cause of Parkinson's disease (PD). LRRK2 contains a functional kinase domain and G2019S, the most prevalent LRRK2 pathogenic mutation,... -
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- Age-related change of Iba-1 immunoreactivity in the adult and aged gerbil spinal cord
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Lee KY, Kang JY, Yun JI, Chung JY, Hwang IK, Won MH, Choi JH
- KMID: 2451239
- Anat Cell Biol.
- 2017 Jun;50(2):135-142.
- doi: 10.5115/acb.2017.50.2.135
In the present study, we examined change of ionized calcium-binding adapter molecule 1 (Iba-1) in the adult and aged gerbil spinal cords. Significant change of morphological feature and neuronal cell... -
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- Phagocytic Roles of Glial Cells in Healthy and Diseased Brains
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Jung YJ, Chung WS
- KMID: 2420385
- Biomol Ther.
- 2018 Jul;26(4):350-357.
- doi: 10.4062/biomolther.2017.133
Glial cells are receiving much attention since they have been recognized as important regulators of many aspects of brain function and disease. Recent evidence has revealed that two different glial... -
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- Effects of Seongpungtang on the Nitric oxide Production of C(6) glial cell and Microglia
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Mun YJ, Kim JS, Sung KK, Chung YT, Woo WH
- KMID: 2224531
- Korean J Anat.
- 2000 Dec;33(6):697-704.
Nitric oxide (NO) can be either neuroprotective or neurotoxic, depending on the cell type from which it is released and the length and severity of the ischemic insult. In the... -
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